N-[4-(3-Nitrophenyl)-2-thiazolyl]acetamide

Base Information

Chemical Name:N-[4-(3-Nitrophenyl)-2-thiazolyl]acetamide
CAS No.:53173-92-5
Molecular Formula:C11H9N3O3S
Molecular Weight:263.277
Hs Code.:
DSSTox Substance ID:DTXSID501265513
ChEMBL ID:CHEMBL4558441

Synonyms:N-[4-(3-Nitrophenyl)-2-thiazolyl]acetamide;53173-92-5;N-[4-(3-nitrophenyl)-1,3-thiazol-2-yl]acetamide;N-(4-(3-nitrophenyl)thiazol-2-yl)acetamide;N-(4-{3-nitrophenyl}-1,3-thiazol-2-yl)acetamide;Oprea1_302641;Oprea1_375435;CHEMBL4558441;SCHEMBL15689083;DTXSID501265513;AC6307;MFCD01023820;STK216630;AKOS000474408;SY030736;CS-0314723;A914489;AG-690/11307136;Z27858596;F0147-0261

Suppliers and Price of N-[4-(3-Nitrophenyl)-2-thiazolyl]acetamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 3 raw suppliers

Chemical Property of N-[4-(3-Nitrophenyl)-2-thiazolyl]acetamide

Chemical Property:

XLogP3:2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:2
Exact Mass:263.03646233
Heavy Atom Count:18
Complexity:334

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(=O)NC1=NC(=CS1)C2=CC(=CC=C2)[N+](=O)[O-]

Technology Process of N-[4-(3-Nitrophenyl)-2-thiazolyl]acetamide

There total 4 articles about N-[4-(3-Nitrophenyl)-2-thiazolyl]acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 2227-64-7
3'-nitro-2-bromoacetophenone

: 591-08-2
acetylthiourea

: 53173-92-5
N-(4-(3'-nitrophenyl)thiazol-2-yl)acetamide

Guidance literature:: In ethanol; at 80 ℃; for 0.5h;
DOI:10.1021/acs.jmedchem.6b00547

Reference yield:

: 121-89-1
3-Nitroacetophenone

: 53173-92-5
N-(4-(3'-nitrophenyl)thiazol-2-yl)acetamide

Guidance literature:: Multi-step reaction with 2 steps

1: pyridinium bromide perbromide, HBr / acetic acid / 0.5 h / Ambient temperature

2: ethanol / 0.5 h / Heating

With hydrogen bromide; pyridinium hydrobromide perbromide; In ethanol; acetic acid;

Reference yield:

: 121-89-1
3-Nitroacetophenone

: 591-08-2
acetylthiourea

: 53173-92-5
N-(4-(3'-nitrophenyl)thiazol-2-yl)acetamide

Guidance literature:: With hydrogen bromide; pyridinium hydrobromide perbromide; Yield given. Multistep reaction; 1.) acetic acid, RT, 4 h, 2.) ethanol, reflux, 4 h;
DOI:10.1248/cpb.43.947