591-08-2 Usage
Chemical Description
N-acetylthiourea and N-benzylthiourea are thioureas, while dimethyl chloroacetal and acetic anhydride are acylating agents.
Chemical Properties
Different sources of media describe the Chemical Properties of 591-08-2 differently. You can refer to the following data:
1. white crystalline powder
2. 1-Acetyl-2-thiourea is a white crystalline solid; forming needles
General Description
White crystalline solid. Noncombustible, but decomposes with heating.
Air & Water Reactions
Slightly soluble in water, soluble in hot water. Hydrolysis occurs rapidly with strong acid/base media.
Reactivity Profile
N-ACETYLTHIOUREA is incompatible with strong oxidizing agents, strong acids and strong bases. Decomposes when heated to give toxic oxides of sulfur and nitrogen.
Health Hazard
TOXIC; inhalation, ingestion or skin contact with material may cause severe injury or death. Contact with molten substance may cause severe burns to skin and eyes. Avoid any skin contact. Effects of contact or inhalation may be delayed. Fire may produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution.
Fire Hazard
Non-combustible, substance itself does not burn but may decompose upon heating to produce corrosive and/or toxic fumes. Some are oxidizers and may ignite combustibles (wood, paper, oil, clothing, etc.). Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated.
Potential Exposure
Studied as possible rodenticide; used in organic synthesis.
Shipping
UN2811 Toxic solids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required.
Purification Methods
Recrystallise the thiourea from AcOH; the solid is washed with Et2O and dried in air then at 100o. [Zahradnik Collect Czech Chem Commun 24 3678 1959, Beilstein 3 IV 354.]
Incompatibilities
Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides.
Waste Disposal
Consult with environmental regulatory agencies for guidance on acceptable disposal practices. Generators of waste containing this contaminant (≥100 kg/mo) must conform with EPA regulations governing storage, transportation, treatment, and waste disposal.
Check Digit Verification of cas no
The CAS Registry Mumber 591-08-2 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 5,9 and 1 respectively; the second part has 2 digits, 0 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 591-08:
(5*5)+(4*9)+(3*1)+(2*0)+(1*8)=72
72 % 10 = 2
So 591-08-2 is a valid CAS Registry Number.
InChI:InChI=1/C3H6N2OS/c1-2(6)5-3(4)7/h1H3,(H3,4,5,6,7)
591-08-2Relevant articles and documents
Design and Structural Characterization of Potent and Selective Inhibitors of Phosphatidylinositol 4 Kinase IIIβ
Rutaganira, Florentine U.,Fowler, Melissa L.,McPhail, Jacob A.,Gelman, Michael A.,Nguyen, Khanh,Xiong, Anming,Dornan, Gillian L.,Tavshanjian, Brandon,Glenn, Jeffrey S.,Shokat, Kevan M.,Burke, John E.
, p. 1830 - 1839 (2016/03/22)
Type III phosphatidylinositol 4-kinase (PI4KIIIβ) is an essential enzyme in mediating membrane trafficking and is implicated in a variety of pathogenic processes. It is a key host factor mediating replication of RNA viruses. The design of potent and specific inhibitors of this enzyme will be essential to define its cellular roles and may lead to novel antiviral therapeutics. We previously reported the PI4K inhibitor PIK93, and this compound has defined key functions of PI4KIIIβ. However, this compound showed high cross reactivity with class I and III PI3Ks. Using structure-based drug design, we have designed novel potent and selective (>1000-fold over class I and class III PI3Ks) PI4KIIIβ inhibitors. These compounds showed antiviral activity against hepatitis C virus. The co-crystal structure of PI4KIIIβ bound to one of the most potent compounds reveals the molecular basis of specificity. This work will be vital in the design of novel PI4KIIIβ inhibitors, which may play significant roles as antiviral therapeutics.
Bismuth chloride mediated synthesis, antimicrobial, and anti-inflammatory activities of new 4-aryl-2-amino thiazoles
Giridhar,Reddy, R. Buchi,Kumar, A. Sunil,Chandra Mouli
scheme or table, p. 2058 - 2072 (2009/07/18)
Synthesis of 4-aryl-2-Amino thiazoles (3a-u), (4a-c), and (5a-c) was achieved from the reaction of 4-butyl phenacyl chlorides (2a-c) with N-substituted thioureas, in the presence of Bismuth Chloride. The antimicrobial and anti-inflammatory activities of the final products were also studied. Copyright Taylor & Francis Group, LLC.
RADICAL ARYLATION OF N,N'-DIACETYLTHIOUREA WITH N-NITROSOACETANILIDE
Yashkina, L. V.,Kopylova, B. V.,Gasanov, R. G.,Freidlina, R. Kh.
, p. 417 - 419 (2007/10/02)
-
