ethyl 3-cyanobutanoate

Base Information

• Chemical Name: ethyl 3-cyanobutanoate
• CAS No.: 22584-00-5
• Molecular Formula: C7H11 N O2
• Molecular Weight: 141.17
• Mol file: 22584-00-5.mol

Synonyms:Butyricacid, 3-cyano-, ethyl ester (8CI); 2-Cyano-1-(ethoxycarbonyl)propane;3-Cyanobutyric acid ethyl ester; Ethyl 3-cyanobutyrate; NSC 244818

Chemical Property of ethyl 3-cyanobutanoate

Chemical Property:

• Vapor Pressure: 0.0687mmHg at 25°C
• Boiling Point: 229.7°Cat760mmHg
• Flash Point: 98.8°C
• Density: 0.998g/cm³

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of ethyl 3-cyanobutanoate

There total 16 articles about ethyl 3-cyanobutanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

(Z)-ethyl 3-cyanobut-2-enoate (40595-04-8) → rac-ethyl 3-cyanobutanoate (22584-00-5)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In tetrahydrofuran; at 20 ℃; under 760.051 Torr;

DOI:10.1021/jo302484p

Reference yield: 70.0%

ethyl crotonate (10544-63-5) + tert-butylisonitrile (119072-55-8,7188-38-7) → rac-ethyl 3-cyanobutanoate (22584-00-5)

Guidance literature:

With aluminium trichloride; In dichloromethane; for 7h; Ambient temperature;

DOI:10.1021/ja00387a050

Reference yield: 60.0%

ethyl 3-bromo-2-cyano-2-methylpropanoate (109539-54-0) → 2-cyano-2-methyl-propionic acid ethyl ester (1572-98-1) + rac-ethyl 3-cyanobutanoate (22584-00-5) + ethyl 3-cyano-2-methylpropanoate (109539-56-2)

Guidance literature:

With cobalt complex of 2,10-diethyl-3,9-dipropyl-1,4,8,11-tetraazaundeca-1,3,8,10-tetraene-1,11-diol; electrolytic process;

DOI:10.1246/cl.1988.835

upstream raw materials:

diethyl ethylidenemalonate

potassium cyanide

ethyl 3-bromobutanoate

sodium cyanide

Downstream raw materials:

menadione

3-methyl-4-(methyl-phenyl-hydrazono)-butyric acid ethyl ester

2-methylbutanedioic acid

6-Hydrazono-5-methyl-tetrahydro-pyridazin-3-one