1572-98-1

Basic information

• Product Name: 2-CYANO-2-METHYLPROPIONIC ACID ETHYL ESTER
• Synonyms: Cyano-dimethyl-aceticacidethylester;cyanomethylpropionicacidethylester;α-Cyano-2-methylpropionicacidethylester;2-CYANO-2-METHYLPROPIONIC ACID ETHYL ESTER;ETHYL 2,2-DIMETHYLCYANOACETATE;ETHYL 2-CYANO-2-METHYLPROPIONATE;2-CYANO-2-METHYLPROPIONIC ACID ETHYL ESTER 98+%;ethyl 2-cyano-2-methylpropanoate
• CAS NO: 1572-98-1
• Molecular Formula: C₇H₁₁NO₂
• Molecular Weight: 141.17
• Product Categories: Miscellaneous Reagents
• Mol File: 1572-98-1.mol
• Article Data: 29

Chemical Properties

• Boiling Point: 185 °C
• Flash Point: 79°C
• Appearance: /
• Density: 0,97 g/cm3
• Vapor Pressure: 0.438mmHg at 25°C
• Refractive Index: 1.3990-1.4120
• Storage Temp.: 2-8°C
• Solubility: Ether
• Water Solubility: Soluble in ether. Not miscible or difficult to mix with water.
• CAS DataBase Reference: 2-CYANO-2-METHYLPROPIONIC ACID ETHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 2-CYANO-2-METHYLPROPIONIC ACID ETHYL ESTER(1572-98-1)
• EPA Substance Registry System: 2-CYANO-2-METHYLPROPIONIC ACID ETHYL ESTER(1572-98-1)

Safety Data

• Statements: 23/24/25-41-22
• Safety Statements: 26-36/37/39-39
• RIDADR: 3276
• HazardClass: IRRITANT
• Hazardous Substances Data: 1572-98-1(Hazardous Substances Data)

Usage

Chemical Properties

Colourless Liquid

Uses

It is employed as a intermediates for pharmaceutical and organic synthesis.

InChI:InChI=1/C7H11NO2/c1-4-10-6(9)7(2,3)5-8/h4H2,1-3H3

Upstream product

• 600-00-0 ethyl 2-bromoisobutyrate 
• 13435-20-6 tetraethylammoniumcyanide 
• 74-88-4 methyl iodide 
• 105-56-6 ethyl 2-cyanoacetate 
• 77-78-1 dimethyl sulfate 
• 75-93-4 methyl bisulfate 
• 74-87-3 methylene chloride 
• 1572-99-2 ethyl 2-cyanopropionate 
• 109539-54-0 ethyl 3-bromo-2-cyano-2-methylpropanoate 
• 18852-51-2 sodium cyanoacetic acid ethyl ester 
• 64-17-5 ethanol 
• 141-52-6 sodium ethanolate 

Downstream Products

• 22426-30-8 2-cyano-2-methylpropanoic acid 
• 59193-77-0 3-amino-2,2-dimethylpropionic acid ethyl ester 
• 7486-91-1 3,3-dimethyl-2-azetidinone 
• 173338-07-3 tert-butyl (3S,5S,6S,8S)-8-(3-amino-2,2-dimethyl-3-oxopropylcarbamoyl)-6-hydroxy-3-(4-methoxy-3-(3-methoxypropoxy)benzyl)-2,9-dimethyldecan-5-ylcarbamate 
• 718633-46-6 N-[(2,2-dimethyl-3-hydroxy)propyl]-4-methylbenzenesulfonamide 
• 2920-38-9 4-cyano-1,1'-biphenyl 

Relevant articles and documents

A simple method for synthesizing 7-oxo-4-thia-1-azabicyclo[3.2.0]-heptane and its 6-methyl derivatives from ethyl cyanoacetate

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Substituted heteroaryl compound and composition thereof, and uses of substituted heteroaryl compound and composition thereof

The present invention provides a substituted heteroaryl compound and a composition thereof, and uses of the substituted heteroaryl compound and the composition, wherein the compound is a compound represented by a formula (I) or a stereoisomer, a tautomer, a nitrogen oxide, a solvate, a metabolite, a pharmaceutically acceptable salt or a prodrug of the compound represented by the formula (I). The present invention further provides a pharmaceutical composition containing the compound, wherein the pharmaceutical composition can regulate activity of protein kinases, particularly Aurora kinases and JAK kinases, and can be used for prevention, treatment, therapy and alleviation of protein kinases, particularly Aurora kinases and JAK kinase activity mediated diseases or disorders.

A new synthesis of bicyclic N,O- and N,S-enaminals by the anionic cyclization of alk-4-ynals with amino alcohols and amino thiols

A reaction of alk-4-ynals with aliphatic amino alcohols or 2-aminoethanethiol in the system DMSO - KOH gives bicyclic N,O- and N,S-enaminals: 6-methylidenehexahydro-2H-pyrrolo[2,1-b][1,3]oxazines, 5-methylidenehexahydropyrrolo[2,1-b]oxazoles, or 5-methyl-