3,7-Dichloro-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one

Base Information

Chemical Name:3,7-Dichloro-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one
CAS No.:5358-44-1
Molecular Formula:C15H10Cl2N2O
Molecular Weight:305.163
Hs Code.:
DSSTox Substance ID:DTXSID10497629
Mol file:5358-44-1.mol

Synonyms:5358-44-1;SCHEMBL10812464;DTXSID10497629;NOXIPAREWUQUGI-UHFFFAOYSA-N;3,7-Dichloro-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one;3,7-Dichloro-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepine-2-one

Suppliers and Price of 3,7-Dichloro-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3,7-Dichloro-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one

Chemical Property:

XLogP3:3.7
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:1
Exact Mass:304.0170183
Heavy Atom Count:20
Complexity:407

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC=C(C=C1)C2=NC(C(=O)NC3=C2C=C(C=C3)Cl)Cl

Technology Process of 3,7-Dichloro-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one

There total 5 articles about 3,7-Dichloro-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.4%

: 604-75-1
oxazepam

: 5358-44-1
3,7-dichloro-1,3-dihydro-5-phenyl-2H-1,4-benzodiazepine-2-one

Guidance literature:: With thionyl chloride; at 60 ℃; for 1.5h;
DOI:10.1002/ardp.200500217

Reference yield:

: 17977-76-3
2-chloro-N-{4-chloro-2-[(hydroxyimino)(phenyl)methyl]phenyl}acetamide

: 5358-44-1
3,7-dichloro-1,3-dihydro-5-phenyl-2H-1,4-benzodiazepine-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: 59.8 percent / aq. NaOH / ethanol / 20 °C / pH 12 - 14

2: 93.4 percent / SOCl₂ / 1.5 h / 60 °C

With sodium hydroxide; thionyl chloride; In ethanol;
DOI:10.1002/ardp.200500217

Reference yield:

: 18097-52-4
2-amino-5-chlorobenzophenone oxime

: 5358-44-1
3,7-dichloro-1,3-dihydro-5-phenyl-2H-1,4-benzodiazepine-2-one

Guidance literature:: Multi-step reaction with 3 steps

1: 94 percent / NaOH / diethyl ether; H₂O / 3 h / 20 °C

2: 59.8 percent / aq. NaOH / ethanol / 20 °C / pH 12 - 14

3: 93.4 percent / SOCl₂ / 1.5 h / 60 °C

With sodium hydroxide; thionyl chloride; In diethyl ether; ethanol; water;
DOI:10.1002/ardp.200500217