18097-52-4

Basic information

• Product Name: 2-AMINO-5-CHLOROBENZOPHENONE OXIME
• Synonyms: 2-AMINO-5-CHLOROBENZOPHENEONE OXIME;2-AMINO-5-CHLOROBENZOPHENONE OXIME;AKOS 90376;TIMTEC-BB SBB003174;(2-amino-5-chlorophenyl)phenyl-methanonoxime;2-amino-5-chlorobenzophenoneoxime,mixtureofsynandantiisomers;2-Amino-5-chlorobenzophenoneα-oxime-,(Z)-;Mixtureofsyn-andanti-isomeres
• CAS NO: 18097-52-4
• Molecular Formula: C₁₃H₁₁ClN₂O
• Molecular Weight: 246.69
• EINECS: 241-999-5
• Product Categories: Aromatic Hydrazides, Hydrazines, Hydrazones and Oximes
• Mol File: 18097-52-4.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 434.9°Cat760mmHg
• Flash Point: 216.8°C
• Appearance: /
• Density: 1.27g/cm³
• Vapor Pressure: 2.47E-08mmHg at 25°C
• Refractive Index: 1.619
• Storage Temp.: Hygroscopic, -20°C Freezer, Under inert atmosphere
• Solubility: Chloroform (Slightly), DMSO (Slightly), Ethyl Acetate (Slightly)
• CAS DataBase Reference: 2-AMINO-5-CHLOROBENZOPHENONE OXIME(CAS DataBase Reference)
• NIST Chemistry Reference: 2-AMINO-5-CHLOROBENZOPHENONE OXIME(18097-52-4)
• EPA Substance Registry System: 2-AMINO-5-CHLOROBENZOPHENONE OXIME(18097-52-4)

Safety Data

• Safety Statements: 24/25
• Hazardous Substances Data: 18097-52-4(Hazardous Substances Data)

Usage

Description

2-Amino-5-Chlorobenzophenone is in the form of a yellow-brown crystalline powder. Its melting point is 98-100°C. It is used to produce intermediates for the synthesis of Oxazolam drug and intermediates for psychotherapeutic agents, such as chlorodiazepoxide and diazepam.1,2

Reference

R. Liao, Synthetic method of Oxazolam drug intermediate 2-amino-5-chlorobenzophenone, Patent CN105461576A S. Nakanishi, W. E. Barth, Process for preparing 6-chloromethyl-4-phenylquinazoline-3-oxide and intermediates therefor, Patent US3932325A

Chemical Properties

yellow crystalline powder

Uses

Intermediate in the preparation of Chlordiazepoxide (C327050) and its metabolites.

Synthesis Reference(s)

The Journal of Organic Chemistry, 30, p. 3957, 1965 DOI: 10.1021/jo01022a519

InChI:InChI=1/C13H11ClN2O/c14-10-6-7-12(15)11(8-10)13(16-17)9-4-2-1-3-5-9/h1-8,17H,15H2/b16-13+

Upstream product

• 719-59-5 5-chloro-2-aminobenzophenone 

Downstream Products

• 4765-61-1 2-methyl-4-phenyl-6-chloroquinazoline 
• 17977-76-3 2-chloro-N-{4-chloro-2-[(hydroxyimino)(phenyl)methyl]phenyl}acetamide 
• 56664-22-3 6-chloro-4-phenyl-2-(phenylamino)quinazoline 3-oxide 
• 84044-34-8 7-Chloro-5-phenyl-3-(3',5'-dimethyl-1'-pyrazolyl)-2,3-dihydro-1H-1,4-benzodiazepin-2-one 
• 13097-03-5 5-Chloro-3-phenylindazole 
• 69882-60-6 2-(chlorofluoroacetamido)-5-chlorobenzophenone oxime 
• 59341-19-4 5-chloro-1-methyl-3-phenylindazole 2-oxide 
• 82980-03-8 2-Benzyloxy-5-chloro-3-phenyl-2H-indazole 
• 82979-97-3 2-azido-5-chlorobenzophenone (E)-oxime 
• 82980-02-7 5-chloro-2-methoxy-3-phenylindazole 
• 28561-52-6 5-chloro-2-hydroxy-3-phenylindazole 
• 84571-52-8 6-chloro-2,2-dimethyl-4-phenyl-1,2,3,4-tetrahydro-quinazoline 
• 84570-99-0 6-Chloro-2-(4-nitro-phenyl)-4-phenyl-1,2,3,4-tetrahydro-quinazoline 
• 84570-98-9 6-Chloro-2-(3-nitro-phenyl)-4-phenyl-1,2,3,4-tetrahydro-quinazoline 

Relevant articles and documents

NOVEL 3-SUBSTITUTED-1,4-BENZODIAZEPINES

The present invention relates to compounds of formula (I). The invention also relates to methods for preparing the compounds and their uses as CCK receptor ligands and CCK antagonists.