4-Methoxy-[1,3]dioxolo[4,5-g]isoquinoline

Base Information

Chemical Name:4-Methoxy-[1,3]dioxolo[4,5-g]isoquinoline
CAS No.:5361-66-0
Molecular Formula:C₁₁H₉NO₃
Molecular Weight:203.197
Hs Code.:
DSSTox Substance ID:DTXSID80274702
Wikidata:Q82004135
Mol file:5361-66-0.mol

Synonyms:4-methoxy-[1,3]dioxolo[4,5-g]isoquinoline;5361-66-0;4-methoxy[1,3]dioxolo[4,5-g]isoquinoline;SCHEMBL10430778;DTXSID80274702;DYHYOYFSCMNDMX-UHFFFAOYSA-N;AKOS026670009;8-methoxy-6,7-methylenedioxyisoquinoline

Suppliers and Price of 4-Methoxy-[1,3]dioxolo[4,5-g]isoquinoline

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 5 raw suppliers

Chemical Property of 4-Methoxy-[1,3]dioxolo[4,5-g]isoquinoline

Chemical Property:

XLogP3:1.9
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:1
Exact Mass:203.058243149
Heavy Atom Count:15
Complexity:236

Purity/Quality:: 95% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=C2C=NC=CC2=CC3=C1OCO3

Technology Process of 4-Methoxy-[1,3]dioxolo[4,5-g]isoquinoline

There total 1 articles about 4-Methoxy-[1,3]dioxolo[4,5-g]isoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.7%

: 5361-66-0
8-methoxy-6,7-methylenedioxyisoquinoline

: 5263-79-6
4-methoxy-[1,3]dioxolo[4,5-g]isoquinoline; hydrochloride

Guidance literature:

Reference yield: 61.0%

: 5361-66-0
8-methoxy-6,7-methylenedioxyisoquinoline

: 98-88-4
benzoyl chloride

: 79659-40-8
2-benzoyl-1-cyano-1,2-dihydro-8-methoxy-6,7-methylenedioxyisoquinoline

Guidance literature:: In dichloromethane; water; for 1h; Ambient temperature;

Reference yield:

: 5361-66-0
8-methoxy-6,7-methylenedioxyisoquinoline

: 79659-42-0
1-(3-hydroxy-4-methoxybenzyl)-8-methoxy-6,7-methylenedioxy-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: Multi-step reaction with 5 steps

1: 61 percent / CH₂Cl₂; H₂O / 1 h / Ambient temperature

2: NaH / dimethylformamide / 1.) -20 deg C, 2 h; 2.) room temperature, 3 h

3: 58 percent / sodium hydroxide / ethanol; H₂O / 2.5 h / Heating

4: 79 percent / Zn/HCl / ethanol / 3 h / Heating

5: 74 percent / H₂ / PtO₂ / ethanol / 24 h / 3750.3 Torr / Ambient temperature

With hydrogenchloride; sodium hydroxide; hydrogen; sodium hydride; zinc; platinum(IV) oxide; In ethanol; dichloromethane; water; N,N-dimethyl-formamide;