2-Hydroxy-4-isopropylbenzaldehyde

Base Information

• Chemical Name: 2-Hydroxy-4-isopropylbenzaldehyde
• CAS No.: 536-32-3
• Molecular Formula: C10H12O2
• Molecular Weight: 164.204
• Hs Code.: 2912499000
• Mol file: 536-32-3.mol

Synonyms:3-Undecyl-2-hydroxynaphthoquinone;2-hydroxy-3-n-undecyl-1,4-naphthoquinone;HUNQ;4-isopropyl-2-hydroxybenzaldehyde;Benzaldehyde, 2-hydroxy-4-(1-methylethyl)-;2-Hydroxy-4-isopropylbenzaldehyd;2-Hydroxy-3-undecyl-1,4-naphthoquinone;4-Isopropyl-salicylaldehyd;2-hydroxy-4-isopropyl-benzaldehyde;

Chemical Property of 2-Hydroxy-4-isopropylbenzaldehyde

Chemical Property:

• Vapor Pressure: 0.006mmHg at 25°C
• Boiling Point: 265.45oC at 760 mmHg
• PKA: 8.24±0.10(Predicted)
• Flash Point: 110.376oC
• PSA: 37.30000
• Density: 1.098g/cm3
• LogP: 2.32810
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

4-Isopropylsalicylaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: 4-Isopropylsalicylaldehyde is a potent partial tyrosinase inhibitor.

Technology Process of 2-Hydroxy-4-isopropylbenzaldehyde

There total 7 articles about 2-Hydroxy-4-isopropylbenzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + 3-isopropylhydroxybenzene (618-45-1) → 2-hydroxy-4-isopropylbenzaldehyde (536-32-3)

Guidance literature:

With triethylamine; magnesium chloride; In acetonitrile; at 10 - 72 ℃; for 2h;

Reference yield: 71.0%

4-isopropyl-2-methoxy-benzaldehyde (181035-65-4) → 2-hydroxy-4-isopropylbenzaldehyde (536-32-3)

Guidance literature:

With lithium chloride; In N,N-dimethyl-formamide; Heating;

DOI:10.1016/j.bmcl.2003.11.033

Reference yield: 55.0%

(4-isopropylbenzaldehyde) (122-03-2) → 2-hydroxy-4-isopropylbenzaldehyde (536-32-3)

Guidance literature:

With [ruthenium(II)(η⁶-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]₂; bis-[(trifluoroacetoxy)iodo]benzene; In 1,2-dichloro-ethane; at 100 ℃; for 8h; chemoselective reaction; Schlenk technique; Inert atmosphere;

DOI:10.1002/anie.201405647

upstream raw materials:

3-isopropylhydroxybenzene

4-isopropyl-2-methoxy-benzaldehyde

3-isopropylanisole

hexamethylenetetramine

Downstream raw materials:

4-isopropyl-2-methoxy-benzaldehyde