181035-65-4

Upstream product

• 6380-20-7 3-isopropylanisole 
• 557-21-1 dicyanozinc 
• 68-12-2 N,N-dimethyl-formamide 
• 618-45-1 3-isopropylhydroxybenzene 
• 93-61-8 N-methyl-N-phenylformamide 
• 536-32-3 2-hydroxy-4-isopropylbenzaldehyde 
• 77-78-1 dimethyl sulfate 

Downstream Products

• 536-32-3 2-hydroxy-4-isopropylbenzaldehyde 

Relevant academic research and scientific papers

2-Hydroxy-4-isopropylbenzaldehyde, a potent partial tyrosinase inhibitor

Chamaecin (2-hydroxy-4-isopropylbenzaldehyde) was synthesized and tested for its tyrosinase inhibitory activity. It partially inhibits the oxidation of L-3,4-dihydroxyphenylalanine (L-DOPA) catalyzed by mushroom tyrosinase with an IC50 of 2.3 μ

Synthesis of novel structurally simplified estrogen analogues with electron-donating groups in ring A

A library of 25 novel estrogen analogues were prepared in five to eight steps from mostly commercially available substituted anisoles via bromination, formylation, Corey-Fuchs reaction, elimination, and Sonogashira reaction. Georg Thieme Verlag Stuttgart.

NOVEL BENSOPHENONE DERIVATIVES OR SALTS THEREOF

A benzophenone derivative represented by the following formula: whereinR1 represents, for example, an optionally substituted heterocyclic group, or a substituted phenyl group; Z represents, for example, an alkylene group; R2 represents, for example, a carboxyl group optionally protected with alkyl;R3 represents, for example, an optionally protected hydroxyl group; R4 represents, for example, an optionally substituted cycloalkyloxy group; and R5 represents, for example, a hydrogen atom, ???or a salt thereof has anti-arthritic activity, inhibits bone destruction caused by arthritis, and provides high safety and excellent pharmacokinetics and thus is useful as therapeutic agent for arthritis. These compounds have inhibitory effect on AP-1 activity and are useful as preventive or therapeutic agent for diseases in which excessive expression of AP-1 is involved.

The Synthesis of Hibiscoquinone C

The synthesis is reported of 7-hydroxy-5-isopropyl-3-methyl-naphthalene-1,2-dione 1 which exhibits identical spectra with tose reported for hibiscoquinone C, thus confirming the structure of the latter.The synthesis was achieved using the Stobbe condensation followed by cyclisation to obtain the naphthoate 13, reduction of the ester to a methyl group, followed by Fremy's salt oxidation and O-demethylation with boron tribromide gave 1.