4,5-DIMETHYL-1H-PYRROLE-2-CARBOXALDEHYDE

Base Information

• Chemical Name: 4,5-DIMETHYL-1H-PYRROLE-2-CARBOXALDEHYDE
• CAS No.: 53700-95-1
• Molecular Formula: C7H9NO
• Molecular Weight: 123.15200
• Mol file: 53700-95-1.mol

Synonyms:2-formyl-4,5-dimethylpyrrole;4,5-Dimethyl-1H-pyrrole-2-carbaldehyde;4,5-dimethyl-pyrrole-2-carbaldehyde;2,3-dimethyl-5-carboxy-pyrrole;4,5-Dimethyl-pyrrol-2-carbaldehyd;formyl-2 dimethyl-4,5 pyrrole;4,5-dimethyl-2-formyl-1H-pyrrole;

Chemical Property of 4,5-DIMETHYL-1H-PYRROLE-2-CARBOXALDEHYDE

Chemical Property:

• Vapor Pressure: 0.033mmHg at 25°C
• PSA: 32.86000
• LogP: 1.44400
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

4,5-Dimethyl-1H-pyrrole-2-carbaldehyde 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4,5-DIMETHYL-1H-PYRROLE-2-CARBOXALDEHYDE

There total 10 articles about 4,5-DIMETHYL-1H-PYRROLE-2-CARBOXALDEHYDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

2,3-dimethyl-1H-pyrrole (600-28-2) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → 4,5-dimethyl-1H-pyrrole-2-carbaldehyde (53700-95-1)

Guidance literature:

N,N-dimethyl-formamide; With trichlorophosphate; at 0 - 20 ℃;

2,3-dimethyl-1H-pyrrole; In dichloromethane; at 0 - 20 ℃;

DOI:10.1021/jo201082z

Reference yield: 2.0%

N-(hydroxy-2' ethyl) amino-3 methyl-2 butene-2 oate d'ethyle (124647-47-8) → 4,5-dimethyl-1H-pyrrole-2-carbaldehyde (53700-95-1) + formyl-3 dimethyl-4,5 pyrrole + formyl-1 dimethyl-2,3 pyrrole (124647-55-8)

Guidance literature:

In tetrahydrofuran; at 400 ℃; sealed tube;

DOI:10.1016/S0040-4020(01)81018-8

Reference yield:

2,3-dimethyl-1H-pyrrole (600-28-2) + hydrogen cyanide (74-90-8) → 4,5-dimethyl-1H-pyrrole-2-carbaldehyde (53700-95-1)

Guidance literature:

With hydrogenchloride; chloroform; und Behandeln des Reaktionsprodukts mit wss.Natriumhydrogencarbonat-Loesung;

DOI:10.1021/ja01852a010

upstream raw materials:

2,3-dimethyl-1H-pyrrole

hydrogen cyanide

ethylmagnesium bromide

N-(hydroxy-2' ethyl) amino-3 methyl-2 butene-2 oate d'ethyle

Downstream raw materials:

(3Z)-[(4,5-dimethyl-1H-pyrrol-2-yl)-methylidenyl]-indolin-2-one