4-(2-Methyl-1,3-dioxolan-2-yl)-1-phenylbutan-1-one

Base Information

Chemical Name:4-(2-Methyl-1,3-dioxolan-2-yl)-1-phenylbutan-1-one
CAS No.:53857-10-6
Molecular Formula:C14H18O3
Molecular Weight:234.295
Hs Code.:
DSSTox Substance ID:DTXSID00563024
Nikkaji Number:J405.153J
Wikidata:Q82447366

Synonyms:4-(2-methyl-1,3-dioxolan-2-yl)-1-phenylbutan-1-one;53857-10-6;DTXSID00563024;4-(2-methyl-1,3-dioxolan-2-yl)-1-phenyl-1-butanone

Suppliers and Price of 4-(2-Methyl-1,3-dioxolan-2-yl)-1-phenylbutan-1-one

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-(2-Methyl-1,3-dioxolan-2-yl)-1-phenylbutan-1-one

Chemical Property:

XLogP3:2.1
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:5
Exact Mass:234.125594432
Heavy Atom Count:17
Complexity:250

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC1(OCCO1)CCCC(=O)C2=CC=CC=C2

Technology Process of 4-(2-Methyl-1,3-dioxolan-2-yl)-1-phenylbutan-1-one

There total 8 articles about 4-(2-Methyl-1,3-dioxolan-2-yl)-1-phenylbutan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 87109-34-0
2-diphenylphosphinoyl-4-(2-methyl-[1,3]dioxolan-2-yl)-1-phenyl-butan-1-one

: 53857-10-6
4-(2-methyl-[1,3]dioxolan-2-yl)-1-phenyl-butan-1-one

Guidance literature:: With potassium hydroxide; In methanol; Heating;
DOI:10.1039/b606873a

Reference yield: 75.0%

: 5978-08-5
1-chloro-4-(1,3-dioxolane)-n-pentane

: 6919-61-5
N-methoxy-N-methylbenzamide

: 53857-10-6
4-(2-methyl-[1,3]dioxolan-2-yl)-1-phenyl-butan-1-one

Guidance literature:: 1-chloro-4-(1,3-dioxolane)-n-pentane; With naphthalene; Lithium-high sodium; In tetrahydrofuran; Inert atmosphere; Cooling with acetone-dry ice;

N-methoxy-N-methylbenzamide; In tetrahydrofuran; at 20 ℃; Cooling with acetone-dry ice; Inert atmosphere;
DOI:10.1021/ja8045475

Reference yield:

: 93-58-3,5705-52-2,80226-58-0
benzoic acid methyl ester

: 53857-10-6
4-(2-methyl-[1,3]dioxolan-2-yl)-1-phenyl-butan-1-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-BuLi / tetrahydrofuran / 0.25 h / 0 °C

1.2: 74 percent / tetrahydrofuran / 2 h / -78 °C

2.1: 82 percent / KOH / methanol / Heating

With potassium hydroxide; n-butyllithium; In tetrahydrofuran; methanol;
DOI:10.1039/b606873a