2,3-Dimethyl-7-methoxy-1H-indole

Base Information

• Chemical Name: 2,3-Dimethyl-7-methoxy-1H-indole
• CAS No.: 53918-89-1
• Molecular Formula: C11H13NO
• Molecular Weight: 175.22700
• Hs Code.: 2933990090
• Mol file: 53918-89-1.mol

Synonyms:1H-Indole,7-methoxy-2,3-dimethyl;2,3-Dimethyl-7-methoxyindol;2,3-Dimethyl-1H-indol-7-yl methyl ether;7-Methoxy-2,3-dimethylindole;7-Methoxy-2,3-dimethyl-indol;

Chemical Property of 2,3-Dimethyl-7-methoxy-1H-indole

Chemical Property:

• PSA: 25.02000
• LogP: 2.79330

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,3-Dimethyl-7-methoxy-1H-indole

There total 4 articles about 2,3-Dimethyl-7-methoxy-1H-indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

2-methoxy-phenylamine (90-04-0) + 2.3-butanediol (513-85-9) → 2,3-Dimethyl-7-methoxyindol (53918-89-1)

Guidance literature:

With [Ru(CO)2(4,5-bis(diphenylphosphino)-9,9-dimethyl-9H-xanthene)]2; [Ru(CO)2(4,5-bis(diphenylphosphino)-9,9-dimethyl-9H-xanthene)]2; toluene-4-sulfonic acid; In tert-Amyl alcohol; at 120 ℃; regioselective reaction;

DOI:10.1039/c3ra40458g

Reference yield: 23.0%

butanone (78-93-3) + N-(2-methoxy-phenyl)-hydrazinecarboxylic acid tert-butyl ester (380383-87-9) → 2,3-Dimethyl-7-methoxyindol (53918-89-1)

Guidance literature:

With toluene-4-sulfonic acid; In ethanol; for 1h; Heating;

DOI:10.1016/j.tetlet.2004.01.011

Reference yield:

3-chloro-2-butanone (4091-39-8) + 2-methoxy-phenylamine (90-04-0) → 2,3-Dimethyl-7-methoxyindol (53918-89-1)

Guidance literature:

In 2-methoxy-ethanol; at 80 - 130 ℃; for 1.5h;

DOI:10.1016/0223-5234(96)89134-3

upstream raw materials:

butanone

(2-methoxyphenyl)hydrazine

3-chloro-2-butanone

2-methoxy-phenylamine