Benzoic acid, 4-[2-[5-chloro-2-[2-[[(chloromethyl)sulfonyl]amino]ethyl]-1-(diphenylmeth yl)-1H-indol-3-yl]ethoxy]-, methyl ester

Base Information

• Chemical Name: Benzoic acid, 4-[2-[5-chloro-2-[2-[[(chloromethyl)sulfonyl]amino]ethyl]-1-(diphenylmeth yl)-1H-indol-3-yl]ethoxy]-, methyl ester
• CAS No.: 540523-72-6
• Molecular Formula: C34H32Cl2N2O5S
• Molecular Weight: 651.61
• Mol file: 540523-72-6.mol

Synonyms:

Chemical Property of Benzoic acid, 4-[2-[5-chloro-2-[2-[[(chloromethyl)sulfonyl]amino]ethyl]-1-(diphenylmeth yl)-1H-indol-3-yl]ethoxy]-, methyl ester

Chemical Property:

Purity/Quality:

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Technology Process of Benzoic acid, 4-[2-[5-chloro-2-[2-[[(chloromethyl)sulfonyl]amino]ethyl]-1-(diphenylmeth yl)-1H-indol-3-yl]ethoxy]-, methyl ester

There total 2 articles about Benzoic acid, 4-[2-[5-chloro-2-[2-[[(chloromethyl)sulfonyl]amino]ethyl]-1-(diphenylmeth yl)-1H-indol-3-yl]ethoxy]-, methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

→ methyl 4-{2-[1-benzhydryl-5-chloro-2-(2-{[(chloromethyl)sulfonyl]amino}ethyl)-1H-indol-3-yl]ethoxy}benzoate (540523-72-6)

Guidance literature:

Reference yield:

methyl 4-{2-[2-(2-aminoethyl)-1-benzhydryl-5-chloro-1H-indol-3-yl]ethoxy}benzoate amine (540522-69-8) + monochloromethanesulfonyl chloride (3518-65-8) → methyl 4-{2-[1-benzhydryl-5-chloro-2-(2-{[(chloromethyl)sulfonyl]amino}ethyl)-1H-indol-3-yl]ethoxy}benzoate (540523-72-6)

Guidance literature:

With sodium hydrogencarbonate; In dichloromethane; water; at 20 ℃;

DOI:10.1021/jm8009876

Reference yield:

methyl 4-{2-[1-benzhydryl-5-chloro-2-(2-{[(chloromethyl)sulfonyl]amino}ethyl)-1H-indol-3-yl]ethoxy}benzoate (540523-72-6) + thiophenol (108-98-5) → methyl 4-(2-{1-benzhydryl-5-chloro-2-[2-({[(phenylsulfanyl)methyl]sulfonyl}amino)ethyl]-1H-indol-3-yl}ethoxy)benzoate (683813-68-5)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In DMF (N,N-dimethyl-formamide); at 120 ℃; for 84h;

upstream raw materials:

methyl 4-{2-[2-(2-aminoethyl)-1-benzhydryl-5-chloro-1H-indol-3-yl]ethoxy}benzoate amine

monochloromethanesulfonyl chloride

Downstream raw materials:

methyl 4-(2-{1-benzhydryl-5-chloro-2-[2-({[(phenylsulfanyl)methyl]sulfonyl}amino)ethyl]-1H-indol-3-yl}ethoxy)benzoate

methyl 4-[2-(1-benzhydryl-5-chloro-2-{2-[({[(2,6-dimethylphenyl)sulfanyl]methyl}sulfonyl)amino]ethyl}-1H-indol-3-yl)ethoxy]benzoate

methyl 4-[2-(1-benzhydryl-5-chloro-2-{2-[({[(2-chlorophenyl)sulfanyl]methyl}sulfonyl)amino]ethyl}-1H-indol-3-yl)ethoxy]benzoate

methyl 4-[2-(1-benzhydryl-5-chloro-2-{2-[({[(2,5-dimethoxyphenyl)sulfanyl]methyl}sulfonyl)amino]ethyl}-1H-indol-3-yl)ethoxy]benzoate

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