3518-65-8Relevant articles and documents
Protocol for Stereoselective Construction of Highly Functionalized Dienyl Sulfonyl Fluoride Warheads
Zhang, Zai-Wei,Wang, Shi-Meng,Fang, Wan-Yin,Lekkala, Ravindar,Qin, Hua-Li
, p. 13721 - 13734 (2020/12/15)
A pyrrolidine-mediated Knoevenagel-type reaction for highly stereoselective construction of novel α-halo-1,3-dienylsulfonyl fluorides was achieved in up to 100% Z-selectivity and high yields at room temperature from condensation of the readily available aldehydes and halomethanesulfonyl fluorides. This protocol provided a class of unique α-halo-1,3-dienylsulfonyl fluorides with wide scope and excellent functional group compatibility. The α-halo-1,3-dienylsulfonyl fluorides were used as versatile building blocks in sulfur fluoride exchange click chemistry, Suzuki reaction, and Sonogashira reaction for the assembly of highly functionalized dienyl sulfonyl fluoride derivatives to be applied as covalent warheads for the discovery of new drugs.
Process for preparing sulfonyl halides
-
, (2008/06/13)
A process for preparing compounds of the general formula (I) from compounds of the general formula (II) and sulfite salts with subsequent halogenation. The solvent which is used for halogenation is an organic solvent which is fully or partly miscible with water. The sulfonyl halides are useful for synthesizing bio active substances.
Sulfonamide analogues of creatinine. The synthesis of 3-amino-4,5-dihydro-l,2,4-thiadiazole 1,1-dioxides from base-induced cyclization reactions
Fares, Fares A.,Ridley, Damon D.,Yin, Ping
, p. 1027 - 1029 (2007/10/03)
We report the preparation of 3-amino-4,5-dihydro-l,2,4-thiadiazole 1,1-dioxide and of its 4-methyl derivative which are of interest as potential analogues of creatinine. The thiadiazoles are obtained from chloromethylsulfonylation of S-benzylisothiourea, followed by cyclization of the chloromethanesulfonamide under basic conditions in the presence of 2-(t-butoxycarbonyloxyimino)-2-phenylacetonitrile or of methyl iodide.
The sulfohaloform reaction revisited and revised
Baum, James Clayton,Hardstaff, William Rayne,Langler, Richard Francis,Makkinje, Anthony
, p. 1687 - 1691 (2007/10/02)
A study of the aqueous chlorinolyses of a series of benzylic dithioacetals along with related α-chlorobenzylic sulfides is reported.These results require a modification of our previously proposed sulfohaloform reaction, so that thionium ion intermediates which have at least one alkyl group on sp2 carbon follow a different pathway.
Asymmetric synthesis of α,β-epoxysulphonate esters (oxiranesulphonate esters)
Nkunya, M. H. H.,Zwanenburg, B.
, p. 461 - 465 (2007/10/02)
The asymmetric phase-transfer-catalyzed Darzens condensation of aldehydes and ketones with the chiral reagent L-menthyl chloromethanesulphonate, using triethylbenzylammonium chloride (TEBA) as the phase-transfer catalyst to give α,β-epoxysulfonate esters (oxiranesulphonate esters) in 9-17 percent chiral induction, is described.The stereochemical course of the chiral induction is discussed.
Phosphoric acid esters, composition and use
-
, (2008/06/13)
Phosphoric (phosphonic) acid esters of the formula STR1 where R1 denotes linear or branched alkyl of up to 4 carbon atoms, R2 denotes linear or branched alkyl, alkoxy or alkylthio, each of up to 4 carbon atoms, mono- or dialkylamino of up to 4 carbon atoms in each alkyl, or phenyl, R3 denotes linear or branched alkoxy or alkylthio of up to 4 carbon atoms, amino, mono- or dialkylamino of up to 4 carbon atoms in each alkyl, alkylalkoxyalkylamino of up to 4 carbon atoms in each alkyl or alkoxyalkyl, dialkoxyalkylamino of up to 4 carbon atoms in each alkoxyalkyl, alkylalkenylamino of up to 4 carbon atoms in each alkyl or alkenyl, alkylalkynylamino of up to 4 carbon atoms in each alkyl or alkynyl, N-methyl-N-methoxyamino, N-(2-methoxyethyl)-N-(2-cyanoethyl), a 5- or 6-membered nitrogenous heterocyclic ring which may contain several nitrogen atoms and optionally oxygen as ring members, R4 denotes unsubstituted or halogen-substituted acyl of up to 4 carbon atoms, alkylsulfonyl or haloalkylsulfonyl of up to 4 carbon atoms in each alkyl or haloalkyl, the group --CO--NR5 R6, R5 and R6 denoting hydrogen, linear or branched alkyl of up to 4 carbon atoms, or - but not simultaneously - phenyl, or R5 and R6 denoting, together with the nitrogen atom whose substituents they are, a 5- or 6-membered heterocyclic ring with further nitrogen atoms and an oxygen atom as ring members, or R4 denotes the group --CO--Y--R7, R7 denoting linear or branched alkyl of up to 4 carbon atoms, phenyl or benzyl, and Y denoting oxygen or sulfur, and X denotes oxygen or sulfur, which are effective against pests, especially insects, mites and ticks; pesticides containing these phosphoric (phosphonic) acid esters as active ingredients; a process for producing these active ingredients; and a process for combating pests with these active ingredients.
DIE ELEKTROFLUORIERUNG VON CHLORMETHYLSULFOCHLORID
Sartori, P.,Habel, W.
, p. 265 - 276 (2007/10/02)
The electrochemical fluorination of ClCH2SO2Cl was studied.The main products were CF4, CF3Cl, SO2F2, SF6, CF3SO2F and ClCF2SO2F.Also minor amounts of CF3H and CF2HCl were formed as well as traces of CFH2Cl and CF2H2 under certain conditions.The yield of ClCF2SO2F increased with descending temperature, concentration and current density.
N-sulfonyl-N-dihalophenylimidazolidinediones
-
, (2008/06/13)
3-(3' -Dihalophenyl)-1-sulfonylimidazolidine-2,4-5'-diones of the formula: STR1 wherein X is a halogen atom, R1 is a C1 -C12 alkyl group, a C2 -C4 alkenyl group or a halogenated C1 -C4 alkyl group having 1 to 3 halogen atoms, and R2 and R3 are individually a hydrogen atom or a methyl group, which show high microbicidal activities against various fungi and bacteria without any material toxicity to mammals and which plants and can be produced by reacting the corresponding 1-unsubstituted compound with a sulfonyl halide.
Anthraquinone disperse dyestuffs
-
, (2008/06/13)
1-Amino-4-hydroxy 2-p-alkoxy-benzenesulfonyloxy anthraquinone disperse dyestuffs have been prepared.
