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3518-65-8

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3518-65-8 Usage

Uses

Chloromethanesulfonyl Chloride is a very useful intermediate for organic synthesis. It enhances citric acid production by Aspergillus niger NCIM-1696 and increases the yield of citric acid. It also functions as a useful intermediate for pharmaceutical synthesis.

Check Digit Verification of cas no

The CAS Registry Mumber 3518-65-8 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 3,5,1 and 8 respectively; the second part has 2 digits, 6 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 3518-65:
(6*3)+(5*5)+(4*1)+(3*8)+(2*6)+(1*5)=88
88 % 10 = 8
So 3518-65-8 is a valid CAS Registry Number.
InChI:InChI=1/CH2Cl2O2S/c2-1-6(3,4)5/h1H2

3518-65-8 Well-known Company Product Price

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  • Alfa Aesar

  • (41486)  Chloromethanesulfonyl chloride, 98%   

  • 3518-65-8

  • 2g

  • 455.0CNY

  • Detail
  • Alfa Aesar

  • (41486)  Chloromethanesulfonyl chloride, 98%   

  • 3518-65-8

  • 10g

  • 1665.0CNY

  • Detail
  • Alfa Aesar

  • (41486)  Chloromethanesulfonyl chloride, 98%   

  • 3518-65-8

  • 50g

  • 7349.0CNY

  • Detail
  • Aldrich

  • (93479)  Chloromethanesulfonylchloride  technical, ≥90% (AT)

  • 3518-65-8

  • 93479-5G-F

  • 834.21CNY

  • Detail

3518-65-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 11, 2017

Revision Date: Aug 11, 2017

1.Identification

1.1 GHS Product identifier

Product name Chloromethanesulfonyl chloride

1.2 Other means of identification

Product number -
Other names EINECS 222-526-1

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:3518-65-8 SDS

3518-65-8Synthetic route

bis(benzylthio)methane
4431-79-2

bis(benzylthio)methane

A

monochloromethanesulfonyl chloride
3518-65-8

monochloromethanesulfonyl chloride

B

Benzyl acetate
140-11-4

Benzyl acetate

C

benzyl chloride
100-44-7

benzyl chloride

Conditions
ConditionsYield
With water; chlorine; acetic acid In water at 20 - 30℃; for 2h;A 53.6%
B 9.8%
C 73.9%
bis(benzylthio)methane
4431-79-2

bis(benzylthio)methane

A

monochloromethanesulfonyl chloride
3518-65-8

monochloromethanesulfonyl chloride

B

Benzyl acetate
140-11-4

Benzyl acetate

C

benzyl chloride
100-44-7

benzyl chloride

D

benzenesulfonyl chloride
1939-99-7

benzenesulfonyl chloride

Conditions
ConditionsYield
With water; chlorine In acetic acid Product distribution; other methyl substituted bis(thiobenzyl) methane derivatives; other products;A 53.6%
B 9.8%
C 73.9%
D 38%
[1,3,5]trithiane
291-21-4

[1,3,5]trithiane

monochloromethanesulfonyl chloride
3518-65-8

monochloromethanesulfonyl chloride

Conditions
ConditionsYield
With potassium chlorate In hydrogenchloride for 5h; Ambient temperature;62%
With chlorine; acetic acid
With hydrogenchloride; potassium chlorate
benzyl chloromethyl sulfide
3970-13-6

benzyl chloromethyl sulfide

A

monochloromethanesulfonyl chloride
3518-65-8

monochloromethanesulfonyl chloride

B

Benzyl acetate
140-11-4

Benzyl acetate

C

benzyl chloride
100-44-7

benzyl chloride

D

benzenesulfonyl chloride
1939-99-7

benzenesulfonyl chloride

Conditions
ConditionsYield
With water; chlorine; acetic acid at 20 - 30℃; for 2h;A 54%
B 16%
C 38%
D 9.4%
benzyl chloromethyl sulfide
3970-13-6

benzyl chloromethyl sulfide

acetic acid
64-19-7

acetic acid

A

monochloromethanesulfonyl chloride
3518-65-8

monochloromethanesulfonyl chloride

B

Benzyl acetate
140-11-4

Benzyl acetate

C

benzyl chloride
100-44-7

benzyl chloride

D

benzenesulfonyl chloride
1939-99-7

benzenesulfonyl chloride

Conditions
ConditionsYield
With chlorine In water at 20 - 30℃; for 2h;A 54%
B 16%
C 38%
D 9.4%
formaldehyd
50-00-0

formaldehyd

monochloromethanesulfonyl chloride
3518-65-8

monochloromethanesulfonyl chloride

Conditions
ConditionsYield
With hydrogenchloride; chlorine; sodium thiosulfate In water at -10℃; for 1.5h;28%
With hydrogenchloride; formaldehyd; hydrogen sulfide 2.) glacial acetic acid, water, 30 deg C, 3-4 h; Yield given. Multistep reaction;
With hydrogenchloride; formaldehyd; hydrogen sulfide; water anschliessendes Behandeln bei -15grad mit Chlor;
chloromethanesulfenyl chloride
26826-80-2

chloromethanesulfenyl chloride

monochloromethanesulfonyl chloride
3518-65-8

monochloromethanesulfonyl chloride

Conditions
ConditionsYield
With dihydrogen peroxide; acetic acid
With chlorine
methane
34557-54-5

methane

monochloromethanesulfonyl chloride
3518-65-8

monochloromethanesulfonyl chloride

Conditions
ConditionsYield
With sulfur dioxide; chlorine bei der Einwirkung von hochfrequenten elektrischen Entladungen;
chloromethyl sodium sulfonate
10352-63-3

chloromethyl sodium sulfonate

monochloromethanesulfonyl chloride
3518-65-8

monochloromethanesulfonyl chloride

Conditions
ConditionsYield
With phosphorus pentachloride; trichlorophosphate
With phosphorus pentachloride (heating);
Stage #1: sodium chloromethanesulfonate With phosphorus pentachloride at 130℃; for 1.25h; Cooling with ice;
Stage #2: With water for 1h; Cooling with ice;
methanesulfonyl chloride
124-63-0

methanesulfonyl chloride

monochloromethanesulfonyl chloride
3518-65-8

monochloromethanesulfonyl chloride

Conditions
ConditionsYield
With pyridine; sulfuryl dichloride In tetrachloromethane
water
7732-18-5

water

chlorine
7782-50-5

chlorine

[1,3,5]trithiane
291-21-4

[1,3,5]trithiane

monochloromethanesulfonyl chloride
3518-65-8

monochloromethanesulfonyl chloride

1.3.5-trithiane

1.3.5-trithiane

monochloromethanesulfonyl chloride
3518-65-8

monochloromethanesulfonyl chloride

Conditions
ConditionsYield
With water; chlorine unter Kuehlung;
With chlorine; acetic acid
chloromethanesulfenyl chloride
26826-80-2

chloromethanesulfenyl chloride

water
7732-18-5

water

chlorine
7782-50-5

chlorine

monochloromethanesulfonyl chloride
3518-65-8

monochloromethanesulfonyl chloride

monochloromethanesulfonyl chloride
3518-65-8

monochloromethanesulfonyl chloride

(4aS,5S)-4,4a,5,6,7,8-hexahydro-5-hydroxy-4a-methylnaphthalen-2(3H)-one
878-47-7, 4242-00-6, 34996-06-0, 50302-16-4, 70191-02-5, 34996-05-9

(4aS,5S)-4,4a,5,6,7,8-hexahydro-5-hydroxy-4a-methylnaphthalen-2(3H)-one

Chloro-methanesulfonic acid (1S,8aS)-8a-methyl-6-oxo-1,2,3,4,6,7,8,8a-octahydro-naphthalen-1-yl ester
182243-72-7

Chloro-methanesulfonic acid (1S,8aS)-8a-methyl-6-oxo-1,2,3,4,6,7,8,8a-octahydro-naphthalen-1-yl ester

Conditions
ConditionsYield
With pyridine at 0 - 20℃; for 0.333333h;100%
monochloromethanesulfonyl chloride
3518-65-8

monochloromethanesulfonyl chloride

testosterone
58-22-0

testosterone

Chloro-methanesulfonic acid (8R,9S,10R,13S,14S,17S)-10,13-dimethyl-3-oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl ester
182243-71-6

Chloro-methanesulfonic acid (8R,9S,10R,13S,14S,17S)-10,13-dimethyl-3-oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl ester

Conditions
ConditionsYield
With pyridine at 0 - 20℃; for 0.25h;100%
With pyridine at 0℃; Substitution;
monochloromethanesulfonyl chloride
3518-65-8

monochloromethanesulfonyl chloride

epicholestanol
516-95-0

epicholestanol

Chloro-methanesulfonic acid (3R,5S,8R,9S,10S,13R,14S,17R)-17-((R)-1,5-dimethyl-hexyl)-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-3-yl ester

Chloro-methanesulfonic acid (3R,5S,8R,9S,10S,13R,14S,17R)-17-((R)-1,5-dimethyl-hexyl)-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-3-yl ester

Conditions
ConditionsYield
With pyridine at 0 - 20℃; for 0.75h;100%
monochloromethanesulfonyl chloride
3518-65-8

monochloromethanesulfonyl chloride

Cholestanol
80-97-7

Cholestanol

Chloro-methanesulfonic acid (3S,5S,8R,9S,10S,13R,14S,17R)-17-((R)-1,5-dimethyl-hexyl)-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-3-yl ester
182243-57-8

Chloro-methanesulfonic acid (3S,5S,8R,9S,10S,13R,14S,17R)-17-((R)-1,5-dimethyl-hexyl)-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-3-yl ester

Conditions
ConditionsYield
With pyridine at 0 - 20℃; for 0.0833333h;100%
With pyridine at 0℃; Substitution;
monochloromethanesulfonyl chloride
3518-65-8

monochloromethanesulfonyl chloride

epicoprostanol
516-92-7

epicoprostanol

Chloro-methanesulfonic acid (3R,5R,8R,9S,10S,13R,14S,17R)-17-((R)-1,5-dimethyl-hexyl)-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-3-yl ester

Chloro-methanesulfonic acid (3R,5R,8R,9S,10S,13R,14S,17R)-17-((R)-1,5-dimethyl-hexyl)-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-3-yl ester

Conditions
ConditionsYield
With pyridine at 0 - 30℃; for 0.166667h;100%
monochloromethanesulfonyl chloride
3518-65-8

monochloromethanesulfonyl chloride

Chloro-methanesulfonic acid (3S,5R,8R,9S,10S,13R,14S,17R)-17-((R)-1,5-dimethyl-hexyl)-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-3-yl ester

Chloro-methanesulfonic acid (3S,5R,8R,9S,10S,13R,14S,17R)-17-((R)-1,5-dimethyl-hexyl)-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-3-yl ester

Conditions
ConditionsYield
With pyridine at 0 - 20℃; for 1h;100%
monochloromethanesulfonyl chloride
3518-65-8

monochloromethanesulfonyl chloride

(2S,3R)-1-Benzyloxymethoxy-2,4-dimethyl-pentan-3-ol
182243-56-7

(2S,3R)-1-Benzyloxymethoxy-2,4-dimethyl-pentan-3-ol

Chloro-methanesulfonic acid (1R,2S)-3-benzyloxymethoxy-1-isopropyl-2-methyl-propyl ester

Chloro-methanesulfonic acid (1R,2S)-3-benzyloxymethoxy-1-isopropyl-2-methyl-propyl ester

Conditions
ConditionsYield
With pyridine at 0 - 20℃; for 0.166667h;100%
monochloromethanesulfonyl chloride
3518-65-8

monochloromethanesulfonyl chloride

(4R,5S,6S)-1-tert-butyldimethylsilyloxy-4,5,7-tribenzyloxy-2(E)-hepten-6-ol
307315-82-8

(4R,5S,6S)-1-tert-butyldimethylsilyloxy-4,5,7-tribenzyloxy-2(E)-hepten-6-ol

(4R,5S,6S)-1-tert-butyldimethylsilyloxy-6-[(chloro-methylsulfonyl)-oxy]-4,5,7-tribenzyloxy-2(E)-heptene
307315-83-9

(4R,5S,6S)-1-tert-butyldimethylsilyloxy-6-[(chloro-methylsulfonyl)-oxy]-4,5,7-tribenzyloxy-2(E)-heptene

Conditions
ConditionsYield
With pyridine at 20℃; for 0.5h; Substitution;100%
monochloromethanesulfonyl chloride
3518-65-8

monochloromethanesulfonyl chloride

[(2R,4S,5R)-2-Phenyl-5-((4R,5S)-2-phenyl-4-vinyl-[1,3,2]dioxaborinan-5-yloxy)-[1,3]dioxan-4-yl]-methanol
475641-71-5

[(2R,4S,5R)-2-Phenyl-5-((4R,5S)-2-phenyl-4-vinyl-[1,3,2]dioxaborinan-5-yloxy)-[1,3]dioxan-4-yl]-methanol

Chloro-methanesulfonic acid (2R,4S,5R)-2-phenyl-5-((4R,5S)-2-phenyl-4-vinyl-[1,3,2]dioxaborinan-5-yloxy)-[1,3]dioxan-4-ylmethyl ester
475641-81-7

Chloro-methanesulfonic acid (2R,4S,5R)-2-phenyl-5-((4R,5S)-2-phenyl-4-vinyl-[1,3,2]dioxaborinan-5-yloxy)-[1,3]dioxan-4-ylmethyl ester

Conditions
ConditionsYield
With 2,6-dimethylpyridine In dichloromethane at 21 - 23℃;100%
(3R*,8aS*)-3-(2-hydroxyethyl)-8a-methoxy-3,6,6,8,8-pentamethyl-8,8a-dihydro-3H-benzo[c][1,2]dioxine-5,7-dione

(3R*,8aS*)-3-(2-hydroxyethyl)-8a-methoxy-3,6,6,8,8-pentamethyl-8,8a-dihydro-3H-benzo[c][1,2]dioxine-5,7-dione

monochloromethanesulfonyl chloride
3518-65-8

monochloromethanesulfonyl chloride

C17H25ClO8S

C17H25ClO8S

Conditions
ConditionsYield
With lutidine In dichloromethane for 12h;100%
(R)-3-(7-amino-1,1-dioxo-1,4-dihydro-1λ6-benzo[1,2,4]thiadiazin-3-yl)-4-hydroxy-1-methyl-1-(3-methyl-butyl)-1H-naphthalen-2-one hydrochloride

(R)-3-(7-amino-1,1-dioxo-1,4-dihydro-1λ6-benzo[1,2,4]thiadiazin-3-yl)-4-hydroxy-1-methyl-1-(3-methyl-butyl)-1H-naphthalen-2-one hydrochloride

monochloromethanesulfonyl chloride
3518-65-8

monochloromethanesulfonyl chloride

1-chloro-N-{3-[(4R)-1-hydroxy-4-methyl-4-(3-methylbutyl)-3-oxo-3,4-dihydronaphthalen-2-yl]-1,1-dioxido-4H-1,2,4-benzothiadiazin-7-yl}methanesulfonamide

1-chloro-N-{3-[(4R)-1-hydroxy-4-methyl-4-(3-methylbutyl)-3-oxo-3,4-dihydronaphthalen-2-yl]-1,1-dioxido-4H-1,2,4-benzothiadiazin-7-yl}methanesulfonamide

Conditions
ConditionsYield
Stage #1: (R)-3-(7-amino-1,1-dioxo-1,4-dihydro-1λ6-benzo[1,2,4]thiadiazin-3-yl)-4-hydroxy-1-methyl-1-(3-methyl-butyl)-1H-naphthalen-2-one hydrochloride; monochloromethanesulfonyl chloride With pyridine In acetone at 20℃; for 24h;
Stage #2: With citric acid In water; ethyl acetate; acetone
100%
monochloromethanesulfonyl chloride
3518-65-8

monochloromethanesulfonyl chloride

2-azido-N,N-diethyl-4,5-O-isopropylidene-3-O-triisopropylsilyl-7-O-trityl-D-glycero-D-allo-heptonamide
635678-99-8

2-azido-N,N-diethyl-4,5-O-isopropylidene-3-O-triisopropylsilyl-7-O-trityl-D-glycero-D-allo-heptonamide

C43H61ClN4O8SSi
934271-05-3

C43H61ClN4O8SSi

Conditions
ConditionsYield
With pyridine at 0℃; for 0.75h;100%
monochloromethanesulfonyl chloride
3518-65-8

monochloromethanesulfonyl chloride

C17H22O7

C17H22O7

C18H23ClO9S

C18H23ClO9S

Conditions
ConditionsYield
With pyridine at 0℃; for 0.166667h;100%
monochloromethanesulfonyl chloride
3518-65-8

monochloromethanesulfonyl chloride

1-(tert-butyl) 2-methyl (2S,3S,4S)-3-allyl-4-hydroxypyrrolidine-1,2-dicarboxylate

1-(tert-butyl) 2-methyl (2S,3S,4S)-3-allyl-4-hydroxypyrrolidine-1,2-dicarboxylate

1-(tert-butyl) 2-methyl (2S,3S,4S)-3-allyl-4-(((chloromethyl)sulfonyl)oxy)pyrrolidine-1,2-dicarboxylate

1-(tert-butyl) 2-methyl (2S,3S,4S)-3-allyl-4-(((chloromethyl)sulfonyl)oxy)pyrrolidine-1,2-dicarboxylate

Conditions
ConditionsYield
With 2,6-dimethylpyridine In dichloromethane at 0 - 20℃; Inert atmosphere;100%
With 2,6-dimethylpyridine In dichloromethane at 0 - 20℃;
monochloromethanesulfonyl chloride
3518-65-8

monochloromethanesulfonyl chloride

C14H20O3

C14H20O3

C15H21ClO5S

C15H21ClO5S

Conditions
ConditionsYield
With 2,6-dimethylpyridine In dichloromethane at 0℃; for 1h; Inert atmosphere;100%
monochloromethanesulfonyl chloride
3518-65-8

monochloromethanesulfonyl chloride

C17H34O5Si

C17H34O5Si

C18H35ClO7SSi

C18H35ClO7SSi

Conditions
ConditionsYield
With 2,6-dimethylpyridine In dichloromethane at 0℃; for 1h; Inert atmosphere;100%
monochloromethanesulfonyl chloride
3518-65-8

monochloromethanesulfonyl chloride

C17H30Br2O5Si

C17H30Br2O5Si

C18H31Br2ClO7SSi

C18H31Br2ClO7SSi

Conditions
ConditionsYield
With 2,6-dimethylpyridine In dichloromethane at 0℃; for 1.5h; Inert atmosphere;100%
monochloromethanesulfonyl chloride
3518-65-8

monochloromethanesulfonyl chloride

(R)-4-benzyl-3-((2R,3S,6R)-6-((2R,5S)-5-((S)-((tert-butyldimethylsilyl)oxy)((2R,4S,5R)-5-(((tert-butyldimethylsilyl)oxy)methyl)-4-((4-methoxybenzyl)oxy)-2-methyltetrahydrofuran-2-yl)methyl)tetrahydrofuran-2-yl)-6-hydroxy-2-methyl-3-((triethylsilyl)oxy)hexanoyl)oxazolidin-2-one
1448328-64-0

(R)-4-benzyl-3-((2R,3S,6R)-6-((2R,5S)-5-((S)-((tert-butyldimethylsilyl)oxy)((2R,4S,5R)-5-(((tert-butyldimethylsilyl)oxy)methyl)-4-((4-methoxybenzyl)oxy)-2-methyltetrahydrofuran-2-yl)methyl)tetrahydrofuran-2-yl)-6-hydroxy-2-methyl-3-((triethylsilyl)oxy)hexanoyl)oxazolidin-2-one

(1R,4S,5R)-6-((R)-4-benzyl-2-oxooxazolidin-3-yl)-1-((2R,5S)-5-((S)-((tert-butyldimethylsilyl)oxy)((2R,4S,5R)-5-(((tert-butyldimethylsilyl)oxy)methyl)-4-((4-methoxybenzyl)oxy)-2-methyltetrahydrofuran-2-yl)methyl)tetrahydrofuran-2-yl)-5-methyl-6-oxo-4-((triethylsilyl)oxy)hexyl chloromethanesulfonate
1448328-65-1

(1R,4S,5R)-6-((R)-4-benzyl-2-oxooxazolidin-3-yl)-1-((2R,5S)-5-((S)-((tert-butyldimethylsilyl)oxy)((2R,4S,5R)-5-(((tert-butyldimethylsilyl)oxy)methyl)-4-((4-methoxybenzyl)oxy)-2-methyltetrahydrofuran-2-yl)methyl)tetrahydrofuran-2-yl)-5-methyl-6-oxo-4-((triethylsilyl)oxy)hexyl chloromethanesulfonate

Conditions
ConditionsYield
With pyridine at 0 - 20℃; for 2.5h;99%
monochloromethanesulfonyl chloride
3518-65-8

monochloromethanesulfonyl chloride

(4R,5R,6R)-1-<(tert-butyldimethylsilyl)oxy>-4,5,7-tris(benzyloxy)-2(E)-hepten-6-ol
172986-75-3

(4R,5R,6R)-1-<(tert-butyldimethylsilyl)oxy>-4,5,7-tris(benzyloxy)-2(E)-hepten-6-ol

(4R,5R,6R)-1-<(tert-butyldimethylsilyl)oxy>-6-<((chloromethyl)sulfonyl)oxy>-4,5,7-tris(benzyloxy)-2(E)-heptene
231618-84-1

(4R,5R,6R)-1-<(tert-butyldimethylsilyl)oxy>-6-<((chloromethyl)sulfonyl)oxy>-4,5,7-tris(benzyloxy)-2(E)-heptene

Conditions
ConditionsYield
In pyridine for 0.5h; Ambient temperature;98%
With pyridine at 20℃; for 0.5h;98%
With pyridine for 0.5h; Ambient temperature;
monochloromethanesulfonyl chloride
3518-65-8

monochloromethanesulfonyl chloride

Methanesulfonic acid (1S,2R)-3-(tert-butyl-diphenyl-silanyloxy)-1-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-2-methyl-propyl ester
182243-64-7

Methanesulfonic acid (1S,2R)-3-(tert-butyl-diphenyl-silanyloxy)-1-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-2-methyl-propyl ester

Chloro-methanesulfonic acid (1S,2R)-3-(tert-butyl-diphenyl-silanyloxy)-1-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-2-methyl-propyl ester
182243-65-8

Chloro-methanesulfonic acid (1S,2R)-3-(tert-butyl-diphenyl-silanyloxy)-1-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-2-methyl-propyl ester

Conditions
ConditionsYield
With pyridine at 0 - 20℃; for 0.5h;98%
monochloromethanesulfonyl chloride
3518-65-8

monochloromethanesulfonyl chloride

(R)-Pantolacton
599-04-2

(R)-Pantolacton

Chloro-methanesulfonic acid (R)-4,4-dimethyl-2-oxo-tetrahydro-furan-3-yl ester
182243-70-5

Chloro-methanesulfonic acid (R)-4,4-dimethyl-2-oxo-tetrahydro-furan-3-yl ester

Conditions
ConditionsYield
With pyridine at 0 - 20℃; for 0.166667h;98%
monochloromethanesulfonyl chloride
3518-65-8

monochloromethanesulfonyl chloride

[(2R,4S,5R)-5-((4R,5S)-4-Allyl-2-phenyl-[1,3,2]dioxaborinan-5-yloxy)-2-phenyl-[1,3]dioxan-4-yl]-methanol
475641-72-6

[(2R,4S,5R)-5-((4R,5S)-4-Allyl-2-phenyl-[1,3,2]dioxaborinan-5-yloxy)-2-phenyl-[1,3]dioxan-4-yl]-methanol

Chloro-methanesulfonic acid (2R,4S,5R)-5-((4R,5S)-4-allyl-2-phenyl-[1,3,2]dioxaborinan-5-yloxy)-2-phenyl-[1,3]dioxan-4-ylmethyl ester
475641-82-8

Chloro-methanesulfonic acid (2R,4S,5R)-5-((4R,5S)-4-allyl-2-phenyl-[1,3,2]dioxaborinan-5-yloxy)-2-phenyl-[1,3]dioxan-4-ylmethyl ester

Conditions
ConditionsYield
With 2,6-dimethylpyridine In dichloromethane at 21 - 23℃;98%
N-[(1R,2R)-1-amino-2,3-dihydro-1H-inden-2-yl]-5-chloro-1H-indole-2-carboxamide trifluoroacetic acid salt

N-[(1R,2R)-1-amino-2,3-dihydro-1H-inden-2-yl]-5-chloro-1H-indole-2-carboxamide trifluoroacetic acid salt

monochloromethanesulfonyl chloride
3518-65-8

monochloromethanesulfonyl chloride

5-chloro-N-((1R,2R)-1-([(chloromethyl)sulfonyl]amino)-2,3-dihydro-1H-inden-2-yl)-1H-indole-2-carboxamide

5-chloro-N-((1R,2R)-1-([(chloromethyl)sulfonyl]amino)-2,3-dihydro-1H-inden-2-yl)-1H-indole-2-carboxamide

Conditions
ConditionsYield
With triethylamine In tetrahydrofuran at 5 - 25℃; for 2h;98%
3-(2,3-dihydro-1H-indol-5-yl)-5-vinyl-3H-imidazo[4,5-b]pyridine

3-(2,3-dihydro-1H-indol-5-yl)-5-vinyl-3H-imidazo[4,5-b]pyridine

monochloromethanesulfonyl chloride
3518-65-8

monochloromethanesulfonyl chloride

3-{1-[(chloromethyl)sulfonyl]2,3-dihydro-1H-indol-5-yl}-5-vinyl-3H-imidazo[4,5-b]pyridine
878389-72-1

3-{1-[(chloromethyl)sulfonyl]2,3-dihydro-1H-indol-5-yl}-5-vinyl-3H-imidazo[4,5-b]pyridine

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 0.333333h;98%
monochloromethanesulfonyl chloride
3518-65-8

monochloromethanesulfonyl chloride

(S)-2-(aminomethyl)pyrrolidine-1-carboxylic acid tert-butyl ester
119020-01-8

(S)-2-(aminomethyl)pyrrolidine-1-carboxylic acid tert-butyl ester

C11H21ClN2O4S
1037297-36-1

C11H21ClN2O4S

Conditions
ConditionsYield
With triethylamine In dichloromethane at 20℃; for 17h;98%
monochloromethanesulfonyl chloride
3518-65-8

monochloromethanesulfonyl chloride

C31H46O10Si

C31H46O10Si

C19H27ClO12S

C19H27ClO12S

Conditions
ConditionsYield
Stage #1: C31H46O10Si With pyridine; tetra-(n-butyl)ammonium iodide; pyridine hydrogenfluoride In dichloromethane at 0℃;
Stage #2: monochloromethanesulfonyl chloride In dichloromethane at -30℃;
98%
monochloromethanesulfonyl chloride
3518-65-8

monochloromethanesulfonyl chloride

C19H36O5Si

C19H36O5Si

C20H37ClO7SSi

C20H37ClO7SSi

Conditions
ConditionsYield
With 2,6-dimethylpyridine In dichloromethane at 0℃; for 1h; Inert atmosphere;98%
monochloromethanesulfonyl chloride
3518-65-8

monochloromethanesulfonyl chloride

(4R,5S,6R)-1-tert-butyldimethylsilyloxy-4,5,7-tribenzyloxy-2(E)-hepten-6-ol
307315-79-3

(4R,5S,6R)-1-tert-butyldimethylsilyloxy-4,5,7-tribenzyloxy-2(E)-hepten-6-ol

(4R,5S,6R)-1-tert-butyldimethylsilyloxy-6-[(chloromethylsulfonyl)-oxy]-4,5,7-tribenzyloxy-2(E)-heptene
307315-80-6

(4R,5S,6R)-1-tert-butyldimethylsilyloxy-6-[(chloromethylsulfonyl)-oxy]-4,5,7-tribenzyloxy-2(E)-heptene

Conditions
ConditionsYield
With pyridine at 20℃; for 0.5h; Substitution;97%
monochloromethanesulfonyl chloride
3518-65-8

monochloromethanesulfonyl chloride

tert-butyl [(3S,5R)-5-({[tert-butyl(dimethyl)silyl]oxy}methyl)-5-{[(3aR,6R,7R,7aS)-7-hydroxy-2,2-dimethyltetrahydro-4H-[1,3]dioxolo[4,5-c]pyran-6-yl]methyl}-2-oxotetrahydrofuran-3-yl]carbamate

tert-butyl [(3S,5R)-5-({[tert-butyl(dimethyl)silyl]oxy}methyl)-5-{[(3aR,6R,7R,7aS)-7-hydroxy-2,2-dimethyltetrahydro-4H-[1,3]dioxolo[4,5-c]pyran-6-yl]methyl}-2-oxotetrahydrofuran-3-yl]carbamate

(3aR,6R,7R,7aR)-6-{[(2R,4S)-4-[(tert-butoxycarbonyl)amino]-2-({[tert-butyl(dimethyl)silyl]oxy}methyl)-5-oxotetrahydrofuran-2-yl]methyl}-2,2-dimethyltetrahydro-4H-[1,3]dioxolo[4,5-c]pyran-7-yl chloromethanesulfonate

(3aR,6R,7R,7aR)-6-{[(2R,4S)-4-[(tert-butoxycarbonyl)amino]-2-({[tert-butyl(dimethyl)silyl]oxy}methyl)-5-oxotetrahydrofuran-2-yl]methyl}-2,2-dimethyltetrahydro-4H-[1,3]dioxolo[4,5-c]pyran-7-yl chloromethanesulfonate

Conditions
ConditionsYield
With pyridine; dmap at 0 - 20℃; for 1.5h;97%
acetic acid 3-hydroxy-5-triisopropylsilanyloxy-2,4-divinyl-cyclopentyl ester

acetic acid 3-hydroxy-5-triisopropylsilanyloxy-2,4-divinyl-cyclopentyl ester

monochloromethanesulfonyl chloride
3518-65-8

monochloromethanesulfonyl chloride

C21H37ClO6SSi

C21H37ClO6SSi

Conditions
ConditionsYield
With pyridine at -10℃; for 4h;95%

3518-65-8Relevant articles and documents

Grossert,Langler

, p. 49 (1973)

Process for preparing sulfonyl halides

-

, (2008/06/13)

A process for preparing compounds of the general formula (I) from compounds of the general formula (II) and sulfite salts with subsequent halogenation. The solvent which is used for halogenation is an organic solvent which is fully or partly miscible with water. The sulfonyl halides are useful for synthesizing bio active substances.

The sulfohaloform reaction revisited and revised

Baum, James Clayton,Hardstaff, William Rayne,Langler, Richard Francis,Makkinje, Anthony

, p. 1687 - 1691 (2007/10/02)

A study of the aqueous chlorinolyses of a series of benzylic dithioacetals along with related α-chlorobenzylic sulfides is reported.These results require a modification of our previously proposed sulfohaloform reaction, so that thionium ion intermediates which have at least one alkyl group on sp2 carbon follow a different pathway.

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