BenzeneMethanol, 4-nitro-.alpha.-(trichloroMethyl)-

Base Information

• Chemical Name: BenzeneMethanol, 4-nitro-.alpha.-(trichloroMethyl)-
• CAS No.: 54075-25-1
• Molecular Formula: C8H6Cl3NO3
• Molecular Weight: 270.5
• Mol file: 54075-25-1.mol

Synonyms:2,2,2-TRICHLORO-1-(4-NITROPHENYL)ETHANOL;BENZENEMETHANOL,4-NITRO-.ALPHA.-(TRICHLOROMETHYL)-;

Chemical Property of BenzeneMethanol, 4-nitro-.alpha.-(trichloroMethyl)-

Chemical Property:

• Melting Point: 93-94 °C(Solv: carbon tetrachloride (56-23-5); ligroine (8032-32-4))
• Boiling Point: 385.3±42.0 °C(Predicted)
• PKA: 11.18±0.20(Predicted)
• PSA: 66.05000
• Density: 1.624±0.06 g/cm3(Predicted)
• LogP: 3.52160

Purity/Quality:

98%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of BenzeneMethanol, 4-nitro-.alpha.-(trichloroMethyl)-

There total 10 articles about BenzeneMethanol, 4-nitro-.alpha.-(trichloroMethyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

chloroform (67-66-3,8013-54-5) + 4-nitrobenzaldehdye (555-16-8) → 4-nitro-α-(trichloromethyl)benzyl alcohol (54075-25-1)

Guidance literature:

With 1,8-diazabicyclo[5.4.0]undec-7-ene; for 0.166667h;

DOI:10.1021/jo000584n

Reference yield: 95.0%

sodium trichloroacetate (650-51-1) + 4-nitrobenzaldehdye (555-16-8) → 4-nitro-α-(trichloromethyl)benzyl alcohol (54075-25-1)

Guidance literature:

With trichloroacetic acid; In N,N-dimethyl-formamide; at 20 ℃;

DOI:10.1021/ol8016484

Reference yield: 85.0%

4-nitrobenzyl chloride (619-73-8) + chloroform (67-66-3,8013-54-5) → 4-nitro-α-(trichloromethyl)benzyl alcohol (54075-25-1)

Guidance literature:

4-nitrobenzyl chloride; chloroform; With Dess-Martin periodane; at 0 - 20 ℃; Inert atmosphere;

With 1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine; at 0 - 20 ℃; for 6h; Inert atmosphere;

DOI:10.1021/jo300725v

upstream raw materials:

4-nitrobenzaldehdye

2,2,2-trichloro-1-phenylethanol

Bromotrichloromethane

trichloroacetic acid

Downstream raw materials:

2,2‐dichloro‐1‐(4‐nitrophenyl)ethan‐1‐one

2-(4-nitrophenyl)ethanol

1-(2,2-dichlorovinyl)-4-nitrobenzene

ethyl [2,2,2-trichloro-1-(4-nitrophenyl)ethyl]carbonate

Refernces

• 1、 -. "PESTICIDAL COMPOUNDS AND METHODS OF USE". Paragraph 0165; 0166; 0235-0238. . Retrieved 2021/04/02.
• 2、 Li, Zhexi,Gupta, Manoj K.,Snowden, Timothy S.. "One-Carbon Homologation of Primary Alcohols and the Reductive Homologation of Aldehydes Involving a Jocic-Type Reaction". . p. 7009 - 7019. Retrieved 2015/11/16.