2-p-Tolyl-2,3-dihydro-1H-isoindole

Base Information

• Chemical Name: 2-p-Tolyl-2,3-dihydro-1H-isoindole
• CAS No.: 54104-83-5
• Molecular Formula: C15H15N
• Molecular Weight: 209.291
• DSSTox Substance ID: DTXSID20401494
• Nikkaji Number: J938.879F
• Wikidata: Q82204633

Synonyms:54104-83-5;ST50996809;SCHEMBL13232537;DTXSID20401494;2-p-Tolyl-2,3-dihydro-1H-isoindole;AKOS003623323;CCG-317511;EU-0050189;SR-01000086198;SR-01000086198-1

Chemical Property of 2-p-Tolyl-2,3-dihydro-1H-isoindole

Chemical Property:

• PSA: 3.24000
• LogP: 3.58020
• XLogP3: 3.5
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 209.120449483
• Heavy Atom Count: 16
• Complexity: 216

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC=C(C=C1)N2CC3=CC=CC=C3C2

Technology Process of 2-p-Tolyl-2,3-dihydro-1H-isoindole

There total 9 articles about 2-p-Tolyl-2,3-dihydro-1H-isoindole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

1,3-dihydroisobenzofuran (496-14-0) + p-toluidine (106-49-0,12221-03-3) → 2-(4-methylphenyl)-2,3-dihydro-1H-isoindole (54104-83-5)

Guidance literature:

p-toluidine; With 1,8-diazabicyclo[5.4.0]undec-7-ene; trichlorophosphate; In 5,5-dimethyl-1,3-cyclohexadiene; at 90 ℃; for 0.25h;

1,3-dihydroisobenzofuran; In 5,5-dimethyl-1,3-cyclohexadiene; at 110 ℃; for 15h; Sealed tube;

DOI:10.1021/acs.joc.9b00377

Reference yield: 92.0%

p-toluidine (106-49-0,12221-03-3) + α,α'-dibromo-o-xylene (91-13-4) → 2-(4-methylphenyl)-2,3-dihydro-1H-isoindole (54104-83-5)

Guidance literature:

In N,N-dimethyl-formamide; for 3h; Heating;

Reference yield: 85.0%

p-toluidine (106-49-0,12221-03-3) + phthalyl alcohol (612-14-6) → 2-(4-methylphenyl)-2,3-dihydro-1H-isoindole (54104-83-5)

Guidance literature:

With caesium carbonate; In toluene; for 24h; Schlenk technique; Inert atmosphere;

DOI:10.1002/chem.201904095

upstream raw materials:

chloroform

p-toluidine

2-methylbenzyl bromide

α,α'-dibromo-o-xylene

Downstream raw materials:

2-p-Tolyl-2,3-dihydro-1H-isoindole; compound with 2,3,5,6-tetrabromo-[1,4]benzoquinone

2-p-Tolyl-2,3-dihydro-1H-isoindole; compound with 2,3,5,6-tetrachloro-[1,4]benzoquinone

2,2'-di-p-tolyl-[1,1']biisoindolylidene-3,3'-dione

o-chloranil

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 54104-83-5 1H-Isoindole, 2,3-dihydro-2-(4-methylphenyl)-

Send

Send

Metric Ton KG G Pound L ML

Send

Send