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Base Information Edit
  • Chemical Name:Chloroform
  • CAS No.:67-66-3
  • Deprecated CAS:8013-54-5
  • Molecular Formula:CHCl3
  • Molecular Weight:119.378
  • Hs Code.:2903.13 oral rat LD50: 910 mg/kg
  • European Community (EC) Number:200-663-8
  • ICSC Number:0027
  • NSC Number:77361
  • UN Number:1888
  • UNII:7V31YC746X
  • DSSTox Substance ID:DTXSID1020306
  • Nikkaji Number:J2.366C
  • Wikipedia:Chloroform
  • Wikidata:Q172275,Q82932548
  • NCI Thesaurus Code:C29815
  • RXCUI:1362698
  • Metabolomics Workbench ID:43927
  • Mol file:67-66-3.mol


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Chemical Property of Chloroform Edit
Chemical Property:
  • Appearance/Colour:Colorless liquid 
  • Vapor Pressure:213.3 hPa at 20°C 
  • Melting Point:-63 °C 
  • Refractive Index:1.4460 
  • Boiling Point:61.2 °C at 760 mmHg 
  • Flash Point:60.5-61.5°C 
  • PSA:0.00000 
  • Density:1.5 g/cm3 
  • LogP:1.98640 
  • Water Solubility.:8 g/L (20℃) 
  • XLogP3:2.3
  • Hydrogen Bond Donor Count:0
  • Hydrogen Bond Acceptor Count:0
  • Rotatable Bond Count:0
  • Exact Mass:117.914383
  • Heavy Atom Count:4
  • Complexity:8
  • Transport DOT Label:Poison
Safty Information:
  • Pictogram(s): HarmfulXn, FlammableF, Toxic
  • Hazard Codes: Xn:Harmful;
  • Statements: R22:; R38:; R40:; R48/20/22:; 
  • Safety Statements: S36/37:; 
MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

  • Chemical Classes:Solvents -> Chlorinated Aliphatics
  • Canonical SMILES:C(Cl)(Cl)Cl
  • Inhalation Risk:A harmful contamination of the air can be reached very quickly on evaporation of this substance at 20 °C.
  • Effects of Short Term Exposure:The substance is irritating to the eyes. The substance may cause effects on the central nervous system, liver and kidneys. The effects may be delayed. Medical observation is indicated.
  • Effects of Long Term Exposure:The substance defats the skin, which may cause dryness or cracking. The substance may have effects on the liver and kidneys. This substance is possibly carcinogenic to humans.
  • Use Description Chloroform, also known as trichloromethane, has been used in various fields for different purposes. In the field of chemistry, it is commonly used as a solvent for various reactions and extractions due to its ability to dissolve a wide range of organic compounds. In the pharmaceutical industry, chloroform has historically been used as an anesthetic, although its use in this capacity has significantly declined due to safety concerns. In the field of forensic science, chloroform has been associated with its historical use as a sedative or for criminal purposes like poisoning, making it a subject of toxicological analysis in criminal investigations. Additionally, it has been used in molecular biology as a phase separation reagent in DNA and RNA extraction procedures. While its applications have evolved and some uses have diminished over time, chloroform remains relevant in specific scientific and industrial contexts.
Technology Process of Chloroform

There total 796 articles about Chloroform which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:
Guidance literature:
With potassium fluoride; zirconium(IV) oxide; at 140 ℃; for 10h; pressure tight reactor;
Guidance literature:
With triethylamine; for 8h; Yields of byproduct given; Heating;
Refernces Edit