(2-Chlorophenyl)(4-methoxyphenyl)methanone

Base Information

• Chemical Name: (2-Chlorophenyl)(4-methoxyphenyl)methanone
• CAS No.: 54118-74-0
• Molecular Formula: C14H11ClO2
• Molecular Weight: 246.693
• Hs Code.: 2914700090
• DSSTox Substance ID: DTXSID60358291
• Nikkaji Number: J908.056B
• Wikidata: Q82138758
• ChEMBL ID: CHEMBL1519635
• Mol file: 54118-74-0.mol

Synonyms:(2-chlorophenyl)(4-methoxyphenyl)methanone;54118-74-0;2-CHLORO-4'-METHOXYBENZOPHENONE;(2-chlorophenyl)-(4-methoxyphenyl)methanone;MFCD02258268;MLS000534505;(2-Chlorophenyl)(4-methoxyphenyl)-methanone;CHEMBL1519635;SCHEMBL11578249;DTXSID60358291;HMS2277N20;AKOS008124649;BS-38008;SMR000141941;CS-0251504;FT-0664754;EN300-54950;SR-01000238792;SR-01000238792-1;Z385418288

Chemical Property of (2-Chlorophenyl)(4-methoxyphenyl)methanone

Chemical Property:

• Vapor Pressure: 6.41E-06mmHg at 25°C
• Melting Point: 79–80.5°C
• Boiling Point: 378.2oC at 760 mmHg
• Flash Point: 156.4oC
• PSA: 26.30000
• Density: 1.212g/cm3
• LogP: 3.57960
• XLogP3: 3.7
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 246.0447573
• Heavy Atom Count: 17
• Complexity: 259

Purity/Quality:

98%Min ^*data from raw suppliers

2-Chloro-4''-methoxybenzophenone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=C(C=C1)C(=O)C2=CC=CC=C2Cl

Technology Process of (2-Chlorophenyl)(4-methoxyphenyl)methanone

There total 13 articles about (2-Chlorophenyl)(4-methoxyphenyl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

1-chloro-2-(4-methoxybenzyl) benzene (53039-46-6) → 2-chloro-4'-methoxybenzophenone (54118-74-0)

Guidance literature:

With oxygen; sodium t-butanolate; In dimethyl sulfoxide; at 50 ℃; for 5h; Sealed tube;

DOI:10.1055/s-0036-1588928

Reference yield: 86.0%

→ 2-chloro-4'-methoxybenzophenone (54118-74-0)

Guidance literature:

With oxygen; sodium t-butanolate; In dimethyl sulfoxide; at 50 ℃; for 5h;

Reference yield: 79.0%

4-methoxyphenylboronic acid (5720-07-0) + ortho-chlorobenzoic acid (118-91-2) → 2-chloro-4'-methoxybenzophenone (54118-74-0)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; water; N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline; In N,N-dimethyl-formamide; at 60 ℃; for 15h; Inert atmosphere;

DOI:10.5012/bkcs.2010.31.9.2672

upstream raw materials:

methoxybenzene

4-methoxyphenylboronic acid

o-chlorobenzoyl chloride

2-chlorobenzoic anhydride

Downstream raw materials:

(2-Chloro-phenyl)-(4-methoxy-3-nitro-phenyl)-methanone

(4-hydroxyphenyl)-(2-chlorophenyl)-methanone

(R)-(2-chlorophenyl)(4-methoxyphenyl)methanol

3-(4-methoxyphenyl)-1H-indazole