Ethyl 4-chloro-2-(dimethylamino)pyrimidine-5-carboxylate

Base Information

Chemical Name:Ethyl 4-chloro-2-(dimethylamino)pyrimidine-5-carboxylate
CAS No.:54127-87-6
Molecular Formula:C9H12ClN3O2
Molecular Weight:229.666
Hs Code.:
DSSTox Substance ID:DTXSID90510926
Wikidata:Q82369488

Synonyms:54127-87-6;Ethyl 4-chloro-2-(dimethylamino)pyrimidine-5-carboxylate;SCHEMBL11144991;DTXSID90510926;HYYWMBIWYPMBGO-UHFFFAOYSA-N;2-Dimethylamino-4-chloro-5-carboethoxypyrimidine;EN300-4475101

Suppliers and Price of Ethyl 4-chloro-2-(dimethylamino)pyrimidine-5-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Ethyl 4-chloro-2-(dimethylamino)pyrimidine-5-carboxylate

Chemical Property:

XLogP3:1.8
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:4
Exact Mass:229.0618043
Heavy Atom Count:15
Complexity:225

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCOC(=O)C1=CN=C(N=C1Cl)N(C)C

Technology Process of Ethyl 4-chloro-2-(dimethylamino)pyrimidine-5-carboxylate

There total 1 articles about Ethyl 4-chloro-2-(dimethylamino)pyrimidine-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 53554-29-3
ethyl 4-hydroxy-2-(methylthio)pyrimidine-5-carboxylate

: 54127-87-6
ethyl 6-chloro-2-dimethylaminopyrimidine-5-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 60 percent / dioxane / 6 h / 110 °C

2: 79 percent / phosphorus oxychloride / 0.5 h / 60 °C

With trichlorophosphate; In 1,4-dioxane;

Reference yield:

: 54127-87-6
ethyl 6-chloro-2-dimethylaminopyrimidine-5-carboxylate

: 72418-34-9
2-Dimethylamino-4-methoxy-pyrimidine-5-carboxylic acid (1-benzyl-piperidin-4-yl)-amide; hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: sodium / Ambient temperature

2: NaOH / methanol; H₂O / 1 h / 65 °C

3: 1.) triethylamine, ethylchloroformate / 1.) DMF, 0 deg C, 30 min, 2.) room temp. overnight

With sodium hydroxide; sodium; chloroformic acid ethyl ester; triethylamine; In methanol; water;

Reference yield:

: 54127-87-6
ethyl 6-chloro-2-dimethylaminopyrimidine-5-carboxylate

: 84332-26-3
2-Dimethylamino-4-methoxy-pyrimidine-5-carboxylic acid (1-benzyl-pyrrolidin-2-ylmethyl)-amide; hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: sodium / Ambient temperature

2: NaOH / methanol; H₂O / 1 h / 65 °C

3: 1.) triethylamine, ethylchloroformate / 1.) DMF, 0 deg C, 30 min, 2.) room temp. overnight

With sodium hydroxide; sodium; chloroformic acid ethyl ester; triethylamine; In methanol; water;