5-Pyrimidinecarboxamide, N-((1-benzyl-2-pyrrolidinyl)methyl)-2-(dimethylamino)-4-methoxy-, dihydrochloride

Base Information

Chemical Name:5-Pyrimidinecarboxamide, N-((1-benzyl-2-pyrrolidinyl)methyl)-2-(dimethylamino)-4-methoxy-, dihydrochloride
CAS No.:84332-26-3
Molecular Formula:C20H27 N5 O2 . 2 Cl H
Molecular Weight:442.389
Hs Code.:
DSSTox Substance ID:DTXSID201004631
Mol file:84332-26-3.mol

Synonyms:84332-26-3;5-Pyrimidinecarboxamide, N-((1-benzyl-2-pyrrolidinyl)methyl)-2-(dimethylamino)-4-methoxy-, dihydrochloride;C20H27N5O2.2ClH;DTXSID201004631;C20-H27-N5-O2.2Cl-H;LS-134784;N-[(1-Benzylpyrrolidin-2-yl)methyl]-2-(dimethylamino)-4-methoxypyrimidine-5-carboximidic acid--hydrogen chloride (1/2)

Suppliers and Price of 5-Pyrimidinecarboxamide, N-((1-benzyl-2-pyrrolidinyl)methyl)-2-(dimethylamino)-4-methoxy-, dihydrochloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
5-PYRIMIDINECARBOXAMIDE, N-((1-BENZYL-2-PYRROLIDINYL)METHYL)-2-(DIMETH YLAMINO)-4-METHOXY-, DIHYDROCHLORIDE 95.00%
5MG
$ 500.14

Total 1 raw suppliers

Chemical Property of 5-Pyrimidinecarboxamide, N-((1-benzyl-2-pyrrolidinyl)methyl)-2-(dimethylamino)-4-methoxy-, dihydrochloride

Chemical Property:

Vapor Pressure:7.57E-15mmHg at 25°C
Boiling Point:603.7°C at 760 mmHg
Flash Point:318.9°C
PSA：74.08000
LogP:4.06230
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:7
Exact Mass:441.1698306
Heavy Atom Count:29
Complexity:469

Purity/Quality:: 5-PYRIMIDINECARBOXAMIDE, N-((1-BENZYL-2-PYRROLIDINYL)METHYL)-2-(DIMETH YLAMINO)-4-METHOXY-, DIHYDROCHLORIDE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CN(C)C1=NC=C(C(=N1)OC)C(=O)NCC2CCCN2CC3=CC=CC=C3.Cl.Cl

Technology Process of 5-Pyrimidinecarboxamide, N-((1-benzyl-2-pyrrolidinyl)methyl)-2-(dimethylamino)-4-methoxy-, dihydrochloride

There total 5 articles about 5-Pyrimidinecarboxamide, N-((1-benzyl-2-pyrrolidinyl)methyl)-2-(dimethylamino)-4-methoxy-, dihydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 53554-29-3
ethyl 4-hydroxy-2-(methylthio)pyrimidine-5-carboxylate

: 84332-26-3
2-Dimethylamino-4-methoxy-pyrimidine-5-carboxylic acid (1-benzyl-pyrrolidin-2-ylmethyl)-amide; hydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1: 60 percent / dioxane / 6 h / 110 °C

2: 79 percent / phosphorus oxychloride / 0.5 h / 60 °C

3: sodium / Ambient temperature

4: NaOH / methanol; H₂O / 1 h / 65 °C

5: 1.) triethylamine, ethylchloroformate / 1.) DMF, 0 deg C, 30 min, 2.) room temp. overnight

With sodium hydroxide; sodium; chloroformic acid ethyl ester; triethylamine; trichlorophosphate; In 1,4-dioxane; methanol; water;

Reference yield:

: 54127-87-6
ethyl 6-chloro-2-dimethylaminopyrimidine-5-carboxylate

: 84332-26-3
2-Dimethylamino-4-methoxy-pyrimidine-5-carboxylic acid (1-benzyl-pyrrolidin-2-ylmethyl)-amide; hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: sodium / Ambient temperature

2: NaOH / methanol; H₂O / 1 h / 65 °C

3: 1.) triethylamine, ethylchloroformate / 1.) DMF, 0 deg C, 30 min, 2.) room temp. overnight

With sodium hydroxide; sodium; chloroformic acid ethyl ester; triethylamine; In methanol; water;

Reference yield:

: 72411-80-4
2-Dimethylamino-4-methoxy-pyrimidine-5-carboxylic acid methyl ester

: 84332-26-3
2-Dimethylamino-4-methoxy-pyrimidine-5-carboxylic acid (1-benzyl-pyrrolidin-2-ylmethyl)-amide; hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: NaOH / methanol; H₂O / 1 h / 65 °C

2: 1.) triethylamine, ethylchloroformate / 1.) DMF, 0 deg C, 30 min, 2.) room temp. overnight

With sodium hydroxide; chloroformic acid ethyl ester; triethylamine; In methanol; water;