1H-1,2,4-Triazole-1-ethanol,a-(2,4-difluorophenyl)-a-[4-(2,4-difluorophenyl)-2-thiazolyl]-

Base Information

Chemical Name:1H-1,2,4-Triazole-1-ethanol,a-(2,4-difluorophenyl)-a-[4-(2,4-difluorophenyl)-2-thiazolyl]-
CAS No.:170862-31-4
Molecular Formula:C19H12 F4 N4 O S
Molecular Weight:420.39
Hs Code.:

Synonyms:1-(2,4-Difluorophenyl)-1-[4-(2,4-difluorophenyl)thiazol-2-yl]-2-(1H-1,2,4-triazol-1-yl)ethanol;ER 24161

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1H-1,2,4-Triazole-1-ethanol,a-(2,4-difluorophenyl)-a-[4-(2,4-difluorophenyl)-2-thiazolyl]-

Chemical Property:

Purity/Quality:

Safty Information:

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Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 1H-1,2,4-Triazole-1-ethanol,a-(2,4-difluorophenyl)-a-[4-(2,4-difluorophenyl)-2-thiazolyl]-

There total 4 articles about 1H-1,2,4-Triazole-1-ethanol,a-(2,4-difluorophenyl)-a-[4-(2,4-difluorophenyl)-2-thiazolyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 288-88-0
1,2,4-Triazole

: 51336-94-8
2-chloro-1-(2,4-dichlorophenyl)ethanone

: 4-(2,4-difluorophenyl)thiazole

: 170862-31-4
1-(2,4-difluorophenyl)-1-(4-(2,4-difluorophenyl)thiazol-2-yl)-2-(1H-1,2,4-triazol-1-yl)-ethanol

Guidance literature:: With n-butyllithium; ammonium chloride; In tetrahydrofuran; N-methyl-acetamide; diethyl ether; hexane; water; ethyl acetate;

Reference yield:

: 288-88-0
1,2,4-Triazole

: 1025877-72-8
2-Chloro-1-(2,4-difluoro-phenyl)-1-[4-(2,4-difluoro-phenyl)-thiazol-2-yl]-ethanol

: 170862-31-4
1-(2,4-difluorophenyl)-1-(4-(2,4-difluorophenyl)thiazol-2-yl)-2-(1H-1,2,4-triazol-1-yl)-ethanol

Guidance literature:: With sodium hydride; Yield given. Multistep reaction; 1,) DMF, 2.), DMF, 60 deg C, 3 h;
DOI:10.1248/cpb.45.1169

Reference yield:

: 51336-94-8
2-chloro-1-(2,4-dichlorophenyl)ethanone

: 170862-31-4
1-(2,4-difluorophenyl)-1-(4-(2,4-difluorophenyl)thiazol-2-yl)-2-(1H-1,2,4-triazol-1-yl)-ethanol

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) n-BuLi / 1.) n-hexane, THF, -78 deg C, 5 min, 2.) n-hexane, THF, -78 deg C, 1 h

2: 1.) NaH / 1,) DMF, 2.), DMF, 60 deg C, 3 h

With n-butyllithium; sodium hydride;
DOI:10.1248/cpb.45.1169