2-Chloro-2',4'-difluoroacetophenone

Base Information Edit

Chemical Name:2-Chloro-2',4'-difluoroacetophenone
CAS No.:51336-94-8
Molecular Formula:C8H5ClF2O
Molecular Weight:190.577
Hs Code.:29147000
European Community (EC) Number:620-343-5
DSSTox Substance ID:DTXSID40343185
Nikkaji Number:J267.331B
Wikidata:Q72518285
ChEMBL ID:CHEMBL105349
Mol file:51336-94-8.mol

Synonyms:51336-94-8;2-Chloro-2',4'-difluoroacetophenone;2-Chloro-1-(2,4-difluorophenyl)ethanone;2,4-Difluorophenacyl Chloride;2-Chloro-2,4-difluoroacetophenone;CHEMBL105349;Ethanone, 2-chloro-1-(2,4-difluorophenyl)-;2-Chloro-1-(2,4-difluoro-phenyl)-ethanone;2',4'-Difluoro-alfa-chloroacetophenone;2',4'-DIFLUORO-2-CHLOROACETOPHENONE;2-Chloro-1-(2,4-Difluorophenyl)Ethan-1-One;1-(2,4-difluorophenyl)-2-chloroethan-1-one;MFCD00013252;2-Chloro-2;ALPHA-CHLORO-2,4-DIFLUOROACETOPHENONE;SCHEMBL2597507;UENGBOCGGKLVJJ-UHFFFAOYSA-;DTXSID40343185;BCP20884;Ethyl1,1,2,2-tetrafluoroethylether;BDBM50119690;STK399765;2,4-difluoro-alpha-chloroacetophenone;AKOS000200625;2-chloro-2', 4'-difluoroacetophenone;2-Chloro-2',4'-difluoro Acetophenone;AC-1571;CS-W015868;UPCMLD0ENAT5630404:001;2-Chloro-2\',4\'-difluoroacetophenone;1-(2,4-difluorophenyl)-2-chloroethanone;PS-11647;2,4-DIFLUORO-2-CHLOROACETOPHENONE;2-chloro-1-(2,4-difluorophenyl)-ethanone;2-chloro-1(2,4-difluorophenyl)-1-ethanone;2-Chloro-1-(2,4-difluorophenyl)ethanone #;2-Chloro-2',4'-difluoroacetophenone, 98%;A7574;AM20040596;C2030;FT-0639987;EN300-22218;J-508621;F0001-1340;Z147642150;2-CHLORO-1-(2,4-DIFLUOROPHENYL)ETHANONE 2'-CHLORO-2,4-DIFLUOROACETOPHENONE 2-CHLORO-2',4'-DIFLUOROACETOPHENONE 2',4

Suppliers and Price of 2-Chloro-2',4'-difluoroacetophenone

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
2-Chloro-2'',4''-difluoroacetophenone
25g
$ 200.00

TRC
2-Chloro-2'',4''-difluoroacetophenone
1g
$ 55.00

TCI Chemical
2-Chloro-2',4'-difluoroacetophenone >98.0%(GC)
25g
$ 116.00

TCI Chemical
2-Chloro-2',4'-difluoroacetophenone >98.0%(GC)
5g
$ 39.00

SynQuest Laboratories
2',4'-Difluorophenacyl chloride 98%
100 g
$ 138.00

SynQuest Laboratories
2',4'-Difluorophenacyl chloride 98%
25 g
$ 48.00

SynQuest Laboratories
2',4'-Difluorophenacyl chloride 98%
5 g
$ 21.00

Sigma-Aldrich
2-Chloro-2′,4′-difluoroacetophenone 98%
25g
$ 79.30

Sigma-Aldrich
2-Chloro-2′,4′-difluoroacetophenone 98%
5g
$ 59.40

Oakwood
2-Chloro-1-(2,4-difluorophenyl)ethanone 98%
1g
$ 10.00

Total 124 raw suppliers

Chemical Property of 2-Chloro-2',4'-difluoroacetophenone Edit

Chemical Property:

Appearance/Colour:white crystalline powder
Melting Point:44-48 °C
Boiling Point:240.877 °C at 760 mmHg
Flash Point:99.479 °C
PSA：17.07000
Density:1.354 g/cm³
LogP:2.38630
Storage Temp.:-20°C Freezer, Under Inert Atmosphere
Sensitive.:Lachrymatory
Solubility.:Chloroform (Slightly)
XLogP3:2.4
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:189.9996988
Heavy Atom Count:12
Complexity:174

Purity/Quality:

99% ^*data from raw suppliers

2-Chloro-2'',4''-difluoroacetophenone ^*data from reagent suppliers

Safty Information:

Pictogram(s): C, Xi
Hazard Codes:C,Xi
Statements: 34-37
Safety Statements: 26-36/37/39-45-25-27

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Canonical SMILES:C1=CC(=C(C=C1F)F)C(=O)CCl
Description 2-Chloro-2′,4′-difluoroacetophenone was used in the synthesis of allyl alcohol1. It can also be tested for inhibition of protein tyrosine phosphatases SHP-1 and PTP1B2.
Uses A α-haloacetophenone derivatives tested for inhibition of protein tyrosine phosphatases SHP-1 and PTP1B. 2-Chloro-2′,4′-difluoroacetophenone was used in the synthesis of allyl alcohol.

Technology Process of 2-Chloro-2',4'-difluoroacetophenone

There total 6 articles about 2-Chloro-2',4'-difluoroacetophenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.5%

: 1440-61-5
N-chloroacetylmorpholine

: 348-57-2
2,4-difluorobromobenzene

: 51336-94-8
2-chloro-1-(2,4-dichlorophenyl)ethanone

Guidance literature:: 2,4-difluorobromobenzene; With magnesium; In tetrahydrofuran; at 30 - 35 ℃; for 2h; Inert atmosphere;

N-chloroacetylmorpholine; In tetrahydrofuran; at 40 ℃; for 2h; Temperature; Solvent;