[3,4-Bis(difluoromethoxy)phenyl]-(2-bromo-5-pyridyl) chloromethane

Base Information

Chemical Name:[3,4-Bis(difluoromethoxy)phenyl]-(2-bromo-5-pyridyl) chloromethane
CAS No.:544710-36-3
Molecular Formula:C14H9BrClF4NO2
Molecular Weight:414.582
Hs Code.:
DSSTox Substance ID:DTXSID30456793

Synonyms:[3,4-bis(difluoromethoxy)phenyl]-(2-bromo-5-pyridyl) chloromethane;544710-36-3;SCHEMBL5942690;DTXSID30456793;[3,4-Bis(difluoromethoxy)phenyl]-(6-bromo-3-pyridyl)chloromethane

Suppliers and Price of [3,4-Bis(difluoromethoxy)phenyl]-(2-bromo-5-pyridyl) chloromethane

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of [3,4-Bis(difluoromethoxy)phenyl]-(2-bromo-5-pyridyl) chloromethane

Chemical Property:

XLogP3:5.8
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:6
Exact Mass:412.94413
Heavy Atom Count:23
Complexity:370

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC(=C(C=C1C(C2=CN=C(C=C2)Br)Cl)OC(F)F)OC(F)F

Technology Process of [3,4-Bis(difluoromethoxy)phenyl]-(2-bromo-5-pyridyl) chloromethane

There total 3 articles about [3,4-Bis(difluoromethoxy)phenyl]-(2-bromo-5-pyridyl) chloromethane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 303165-20-0
(+/-)-[3,4-bis(difluoromethoxy)phenyl]-(2-bromopyridin-5-yl)methanol

: 544710-36-3
[3,4-Bis(difluoromethoxy)phenyl]-(6-bromo-pyridin-3-yl)chloromethane

Guidance literature:: With thionyl chloride; In dichloromethane;
DOI:10.1016/S0960-894X(02)01030-2

Reference yield:

: 624-28-2
2,5-dibromopyridine

: 544710-36-3
[3,4-Bis(difluoromethoxy)phenyl]-(6-bromo-pyridin-3-yl)chloromethane

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-BuLi / diethyl ether; hexane / 0.75 h / -78 °C

1.2: 70 percent / diethyl ether; hexane / 2 h

2.1: SOCl₂ / CH₂Cl₂ / 0.75 h / 20 °C

With n-butyllithium; thionyl chloride; In diethyl ether; hexane; dichloromethane;
DOI:10.1021/jm0204542