2-Phenacyl-1-tetralone

Base Information

• Chemical Name: 2-Phenacyl-1-tetralone
• CAS No.: 54669-72-6
• Molecular Formula: C18H16O2
• Molecular Weight: 264.324
• DSSTox Substance ID: DTXSID50483369
• Nikkaji Number: J2.188.529K

Synonyms:2-phenacyl-1-tetralone;54669-72-6;SCHEMBL11842381;DTXSID50483369;ITTLQABJFKKHGL-UHFFFAOYSA-N

Chemical Property of 2-Phenacyl-1-tetralone

Chemical Property:

• XLogP3: 3.4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 264.115029749
• Heavy Atom Count: 20
• Complexity: 368

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1CC2=CC=CC=C2C(=O)C1CC(=O)C3=CC=CC=C3

Technology Process of 2-Phenacyl-1-tetralone

There total 10 articles about 2-Phenacyl-1-tetralone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

2-benzoyl-2-iodomethyl-3,4-dihydro-2H-naphthalen-1-one → 7-benzoyl-6,7,8,9-tetrahydro-benzocyclohepten-5-one + 2-(2-oxo-2-phenylethyl)-3,4-dihydronaphthalen-1(2H)-one (54669-72-6)

Guidance literature:

With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride;

DOI:10.1016/j.tetlet.2005.05.036

Reference yield: 66.0%

2-methylene-1-tetralone (13203-73-1) + benzaldehyde (100-52-7) → 2-(2-oxo-2-phenylethyl)-3,4-dihydronaphthalen-1(2H)-one (54669-72-6)

Guidance literature:

With triethylamine; 3,4-dimethyl-5-(2-hydroxyethyl)thiazolium iodide; In ethanol; at 60 - 90 ℃; for 15h;

Reference yield:

1-trimethylsiloxy-3,4-dihydronaphthalene (38858-72-9) + C14H13IO2 → 2-(2-oxo-2-phenylethyl)-3,4-dihydronaphthalen-1(2H)-one (54669-72-6)

Guidance literature:

In dichloromethane; at -78 - 20 ℃; for 1h; Inert atmosphere;

DOI:10.3762/bjoc.14.84

upstream raw materials:

2-dimethylaminomethyl-3,4-dihydro-naphthalen-1-one

benzaldehyde

2-methylene-1-tetralone

1-(3,4-dihydro-1-naphthalenyl)pyrrolidine

Downstream raw materials:

1-(3-Carboxyphenyl)-4,5-dihydro-2-phenylbenz[g]indole

2-phenyl-4,5-dihydro-1H-benzo[g]indole

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