8-(Tetrahydro-2H-pyran-2-yloxy)octanoic acid

Base Information

Chemical Name:8-(Tetrahydro-2H-pyran-2-yloxy)octanoic acid
CAS No.:54699-43-3
Molecular Formula:C13H24O4
Molecular Weight:244.331
Hs Code.:2932999099
Mol file:54699-43-3.mol

Synonyms:8-(tetrahydro-2'H-pyran-2'-yl-oxy)-1-octanoic acid;8-(tetrahydro-2H-pyran-2-yloxy)octanoic acid;Octanoic acid,8-[(tetrahydro-2H-pyran-2-yl)oxy];

Suppliers and Price of 8-(Tetrahydro-2H-pyran-2-yloxy)octanoic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 4 raw suppliers

Chemical Property of 8-(Tetrahydro-2H-pyran-2-yloxy)octanoic acid

Chemical Property:

Boiling Point:386.3±37.0 °C(Predicted)
PKA:4.77±0.10(Predicted)
PSA：55.76000
Density:1.05±0.1 g/cm3(Predicted)
LogP:2.95480

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 8-(Tetrahydro-2H-pyran-2-yloxy)octanoic acid

There total 6 articles about 8-(Tetrahydro-2H-pyran-2-yloxy)octanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 110-87-2
3,4-dihydro-2H-pyran

: 764-89-6
8-hydroxycaprylic acid

: 54699-43-3
8-(tetrahydro-2'H-pyran-2'-yl-oxy)-1-octanoic acid

Guidance literature:: With toluene-4-sulfonic acid; In diethyl ether; for 16h; Ambient temperature;
DOI:10.1016/S0040-4020(99)00041-1

Reference yield: 41.0%

: 57221-80-4
8-tetrahydropyranyloxyoctanal

: 54699-43-3
8-(tetrahydro-2'H-pyran-2'-yl-oxy)-1-octanoic acid

Guidance literature:: 8-tetrahydropyranyloxyoctanal; With sodium dihydrogenphosphate dihydrate; In water; acetonitrile; at -15 ℃; for 0.166667h;

With dihydrogen peroxide; In water; acetonitrile; for 0.0833333h;

With sodium chlorite; In water; acetonitrile; for 1h;

Reference yield:

: 629-41-4
1,8-Octanediol

: 54699-43-3
8-(tetrahydro-2'H-pyran-2'-yl-oxy)-1-octanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: pyridinium p-toluenesulfonate / chloroform / 18 h / 20 °C / Inert atmosphere

2.1: oxalyl dichloride; dimethyl sulfoxide / chloroform / 2 h / -55 °C

2.2: 0.75 h / -55 - 0 °C

3.1: sodium dihydrogenphosphate dihydrate / water; acetonitrile / 0.17 h / -15 °C

3.2: 0.08 h

3.3: 1 h

With sodium dihydrogenphosphate dihydrate; oxalyl dichloride; pyridinium p-toluenesulfonate; dimethyl sulfoxide; In chloroform; water; acetonitrile; 2.1: |Swern Oxidation;