1-(3-TRIFLUOROMETHOXY-PHENYL)-PIPERAZINE

Base Information

• Chemical Name: 1-(3-TRIFLUOROMETHOXY-PHENYL)-PIPERAZINE
• CAS No.: 54711-69-2
• Molecular Formula: C11H13F3N2O
• Molecular Weight: 246.232
• Mol file: 54711-69-2.mol

Synonyms:1-(3-(Trifluoromethoxy)phenyl)piperazine;Piperazine,1-[3-(trifluoromethoxy)phenyl];

Chemical Property of 1-(3-TRIFLUOROMETHOXY-PHENYL)-PIPERAZINE

Chemical Property:

• PSA: 24.50000
• LogP: 2.38860

Purity/Quality:

98% ^*data from raw suppliers

1-[3-(Trifluoromethoxy)phenyl]piperazine 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(3-TRIFLUOROMETHOXY-PHENYL)-PIPERAZINE

There total 5 articles about 1-(3-TRIFLUOROMETHOXY-PHENYL)-PIPERAZINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

bis-(2-chloroethyl)amine hydrochloride (821-48-7) + m-trifluoromethoxyaniline (1535-73-5) → 1-(3-trifluoromethoxyphenyl)piperazine (54711-69-2)

Guidance literature:

bis-(2-chloroethyl)amine hydrochloride; m-trifluoromethoxyaniline; at 190 ℃; for 0.0833333h; Microwave irradiation;

With sodium hydrogencarbonate; In water;

Reference yield:

piperazine (110-85-0) + Diisopropylimidazolium chloride + 1-bromo-3-(trifluoromethoxy)benzene (2252-44-0) → 1-(3-trifluoromethoxyphenyl)piperazine (54711-69-2)

Guidance literature:

With potassium tert-butylate; palladium diacetate; In 1,4-dioxane;

Reference yield:

C16H21F3N2O3 (1121600-03-0) → 1-(3-trifluoromethoxyphenyl)piperazine (54711-69-2)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1h;

DOI:10.1021/jm401752p

upstream raw materials:

bis-(2-chloroethyl)amine hydrochloride

m-trifluoromethoxyaniline

piperazine

1-bromo-3-(trifluoromethoxy)benzene

Downstream raw materials:

[5-(3-{4-[3-(trifluoromethoxy)phenyl]piperazin-1-yl}isoxazol-5-yl)-1H-tetrazol-1-yl]acetic acid

[5-(3-{4-[3-(trifluoromethoxy)phenyl]piperazin-1-yl}isoxazol-5-yl)-2H-tetrazol-2-yl]acetic acid

1-[5-(2H-tetrazol-5-yl)isoxazol-3-yl]-4-[3-(trifluoromethoxy)phenyl]piperazine

3-{4-[3-(trifluoromethoxy)phenyl]piperazin-1-yl}isoxazole-5-carbonitrile

Refernces

• 1、 Foley, Timothy L.,Rai, Ganesha,Yasgar, Adam,Daniel, Thomas,Baker, Heather L.,Attene-Ramos, Matias,Kosa, Nicolas M.,Leister, William,Burkart, Michael D.,Jadhav, Ajit,Simeonov, Anton,Maloney, David J.. "4-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)- N -(4-methoxypyridin-2-yl) piperazine-1-carbothioamide (ML267), a potent inhibitor of bacterial phosphopantetheinyl transferase that attenuates secondary metabolism and thwarts bacterial growth". supporting information. p. 1063 - 1078. Retrieved 2014/03/21.
• 2、 -. "HETEROCYCLIC DERIVATIVES AS INHIBITORS OF STEAROYL-COENZYME A DELTA-9 DESATURASE". Page/Page column 112. . Retrieved 2010/09/17.