1-[5-(2H-tetrazol-5-yl)isoxazol-3-yl]-4-[3-(trifluoromethoxy)phenyl]piperazine

Base Information

Chemical Name:1-[5-(2H-tetrazol-5-yl)isoxazol-3-yl]-4-[3-(trifluoromethoxy)phenyl]piperazine
CAS No.:1241898-66-7
Molecular Formula:C₁₅H₁₄F₃N₇O₂
Molecular Weight:381.317
Hs Code.:

Synonyms:1-[5-(2H-tetrazol-5-yl)isoxazol-3-yl]-4-[3-(trifluoromethoxy)phenyl]piperazine

Suppliers and Price of 1-[5-(2H-tetrazol-5-yl)isoxazol-3-yl]-4-[3-(trifluoromethoxy)phenyl]piperazine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-[5-(2H-tetrazol-5-yl)isoxazol-3-yl]-4-[3-(trifluoromethoxy)phenyl]piperazine

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 1-[5-(2H-tetrazol-5-yl)isoxazol-3-yl]-4-[3-(trifluoromethoxy)phenyl]piperazine

There total 5 articles about 1-[5-(2H-tetrazol-5-yl)isoxazol-3-yl]-4-[3-(trifluoromethoxy)phenyl]piperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1241898-65-6
3-{4-[3-(trifluoromethoxy)phenyl]piperazin-1-yl}isoxazole-5-carbonitrile

: 1241898-66-7
1-[5-(2H-tetrazol-5-yl)isoxazol-3-yl]-4-[3-(trifluoromethoxy)phenyl]piperazine

Guidance literature:: 3-{4-[3-(trifluoromethoxy)phenyl]piperazin-1-yl}isoxazole-5-carbonitrile; With sodium azide; ammonium chloride; In N,N-dimethyl-formamide; at 75 ℃; for 2h;

With hydrogenchloride; In water; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 54711-69-2
1-(3-trifluoromethoxyphenyl)piperazine

: 1241898-66-7
1-[5-(2H-tetrazol-5-yl)isoxazol-3-yl]-4-[3-(trifluoromethoxy)phenyl]piperazine

Guidance literature:: Multi-step reaction with 4 steps

1: N-ethyl-N,N-diisopropylamine / 16 h / Reflux

2: sodium acetate; iodine / chlorobenzene / 9 h / Reflux

3: N-ethyl-N,N-diisopropylamine; trifluoroacetic anhydride / dichloromethane / -78 - 0 °C

4: sodium azide; ammonium chloride / N,N-dimethyl-formamide / 2 h / 75 °C

With sodium azide; iodine; sodium acetate; ammonium chloride; N-ethyl-N,N-diisopropylamine; trifluoroacetic anhydride; In dichloromethane; N,N-dimethyl-formamide; chlorobenzene;

Reference yield:

: 1241898-64-5
3-{4-[3-(trifluoromethoxy)phenyl]piperazin-1-yl}isoxazole-5-carboxamide

: 1241898-66-7
1-[5-(2H-tetrazol-5-yl)isoxazol-3-yl]-4-[3-(trifluoromethoxy)phenyl]piperazine

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine; trifluoroacetic anhydride / dichloromethane / -78 - 0 °C

2: sodium azide; ammonium chloride / N,N-dimethyl-formamide / 2 h / 75 °C

With sodium azide; ammonium chloride; N-ethyl-N,N-diisopropylamine; trifluoroacetic anhydride; In dichloromethane; N,N-dimethyl-formamide;