5'-o-(Tert-butyldimethylsilyl)uridine

Base Information

Chemical Name:5'-o-(Tert-butyldimethylsilyl)uridine
CAS No.:54925-65-4
Molecular Formula:C₁₅H₂₆N₂O₆Si
Molecular Weight:358.467
Hs Code.:
DSSTox Substance ID:DTXSID90435125
Nikkaji Number:J806.014B
Wikidata:Q82249831
ChEMBL ID:CHEMBL3797421

Synonyms:5'-o-(tert-butyldimethylsilyl)uridine;SCHEMBL9218570;CHEMBL3797421;5'-O-t-butyldimethylsilyluridine;DTXSID90435125;1-[(2R,3R,4S,5R)-5-[[tert-butyl(dimethyl)silyl]oxymethyl]-3,4-dihydroxyoxolan-2-yl]pyrimidine-2,4-dione

Suppliers and Price of 5'-o-(Tert-butyldimethylsilyl)uridine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Biosynth Carbosynth
5'-O-tert-Butyldimethylsilyluridine
10 g
$ 500.00

Biosynth Carbosynth
5'-O-tert-Butyldimethylsilyluridine
5 g
$ 375.00

Biosynth Carbosynth
5'-O-tert-Butyldimethylsilyluridine
25 g
$ 1000.00

AK Scientific
5'-o-(Tert-butyldimethylsilyl)uridine
10g
$ 725.00

Total 4 raw suppliers

Chemical Property of 5'-o-(Tert-butyldimethylsilyl)uridine

Chemical Property:

Melting Point:96-97 °C
PSA：114.04000
Density:1.238±0.06 g/cm3(Predicted)
LogP:0.58990
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:5
Exact Mass:358.15601309
Heavy Atom Count:24
Complexity:545

Purity/Quality:

97% ^*data from raw suppliers

5'-O-tert-Butyldimethylsilyluridine ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)(C)[Si](C)(C)OCC1C(C(C(O1)N2C=CC(=O)NC2=O)O)O
Isomeric SMILES:CC(C)(C)[Si](C)(C)OC[C@@H]1[C@H]([C@H]([C@@H](O1)N2C=CC(=O)NC2=O)O)O

Technology Process of 5'-o-(Tert-butyldimethylsilyl)uridine

There total 4 articles about 5'-o-(Tert-butyldimethylsilyl)uridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 18162-48-6
tert-butyldimethylsilyl chloride

: 58-96-8
uridine

: 87418-77-7,54925-65-4
5'-O-(tert-butyldimethylsilyl)uridine

Guidance literature:: With silver nitrate; In tetrahydrofuran; for 3h; Ambient temperature; add of (n-Bu)4NSO₃H;
DOI:10.1016/S0040-4039(01)92340-8

Reference yield: 97.0%

: 1227248-63-6
C₂₀H₃₄N₂O₈Si

: 87418-77-7,54925-65-4
5'-O-(tert-butyldimethylsilyl)uridine

Guidance literature:: In 2,2,2-trifluoroethanol; at 100 ℃; for 1h; Microwave irradiation;
DOI:10.1016/j.tetlet.2010.02.100

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 58-96-8
uridine

: 87418-77-7,54925-65-4
5'-O-(tert-butyldimethylsilyl)uridine

: 54925-67-6
3',5'-bis-O-(tert-butyldimethylsilyl)uridine

: 54925-66-5
2',5'-bis-O-(tert-butyldimethylsilyl)uridine

Guidance literature:: With pyridine; In N,N-dimethyl-formamide; for 13h; Product distribution; other nucleosides; variation of reagents, solvents and times;
DOI:10.1139/v82-165