Benzeneacetic acid, a-methyl-, 4-nitrophenyl ester, (R)-

Base Information

• Chemical Name: Benzeneacetic acid, a-methyl-, 4-nitrophenyl ester, (R)-
• CAS No.: 55019-71-1
• Molecular Formula: C15H13NO4
• Molecular Weight: 271.273
• Mol file: 55019-71-1.mol

Synonyms:

Chemical Property of Benzeneacetic acid, a-methyl-, 4-nitrophenyl ester, (R)-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzeneacetic acid, a-methyl-, 4-nitrophenyl ester, (R)-

There total 5 articles about Benzeneacetic acid, a-methyl-, 4-nitrophenyl ester, (R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

4-nitro-phenol (100-02-7,78813-13-5,89830-32-0) + (R)-(-)-2-phenylpropionyl chloride (36240-11-6) → (-)-(R)-p-nitrophenyl α-phenylpropionate (55019-71-1)

Guidance literature:

With pyridine; In toluene; for 6h; Ambient temperature;

DOI:10.1039/P29870000193

Reference yield: 78.0%

4-nitro-phenol (100-02-7,78813-13-5,89830-32-0) + (R)-2-Phenylpropionic acid (7782-26-5) → (-)-(R)-p-nitrophenyl α-phenylpropionate (55019-71-1)

Guidance literature:

With dicyclohexyl-carbodiimide; In ethyl acetate; 1) 0 deg, 2) r.t.;

DOI:10.1248/cpb.39.2748

Reference yield:

2-phenylpropionic acid p-nitrophenyl ester (104013-15-2) → hydratropic acid (492-37-5,2328-24-7) + (+)-(S)-p-nitrophenyl α-phenylpropionate (55019-72-2) + (-)-(R)-p-nitrophenyl α-phenylpropionate (55019-71-1)

Guidance literature:

With Candida antarctica lipase B RG₄₀₁ mutant; water; In aq. phosphate buffer; acetonitrile; at 30 ℃; for 3h; pH=7.5; Reagent/catalyst; Time; enantioselective reaction; Resolution of racemate; Enzymatic reaction;

DOI:10.1021/ja310455t

upstream raw materials:

4-nitro-phenol

(R)-2-Phenylpropionic acid

(R)-(-)-2-phenylpropionyl chloride

2-phenylpropionic acid p-nitrophenyl ester

Downstream raw materials:

4-nitro-phenol

(R)-2-Phenylpropionic acid