4-(TRIFLUOROMETHYL)STYRENE

Base Information

• Chemical Name: 4-(TRIFLUOROMETHYL)STYRENE
• CAS No.: 55186-75-9
• Molecular Formula: C10H9F3
• Molecular Weight: 186.177
• Hs Code.: 2903999090
• Mol file: 55186-75-9.mol

Synonyms:4-(1-methylvinyl)-1-(trifluoromethyl)benzene;4-CF3C6H4C(CH3)CH2;Benzene,1-(1-methylethenyl)-4-(trifluoromethyl);(pCF3C6H4)(methyl)styrene;1-isopropenyl-4-trifluoromethyl-benzene;1-(prop-1-en-2-yl)-4-(trifluoromethyl)benzene;

Chemical Property of 4-(TRIFLUOROMETHYL)STYRENE

Chemical Property:

• Refractive Index: n20/D 1.466(lit.)
• Boiling Point: 65-66?°C40?mm Hg(lit.)
• Flash Point: 108?°F
• PSA: 0.00000
• Density: 1.165?g/mL?at 25?°C(lit.)
• LogP: 3.73850
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

1-Isopropenyl-4-(trifluoromethyl)benzene 97% ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 10-36/37/38
• Safety Statements: 26-36/37

MSDS Files:

Useful:

Technology Process of 4-(TRIFLUOROMETHYL)STYRENE

There total 9 articles about 4-(TRIFLUOROMETHYL)STYRENE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

2-(4-(trifluoromethyl)phenyl)propan-2-ol (2252-62-2) → 4-trifluoromethyl-α-methylstyrene (55186-75-9)

Guidance literature:

With potassium hydrogensulfate; In benzene; Heating;

DOI:10.1002/prac.19963380147

Reference yield: 84.0%

1-(4-trifluoromethylphenyl)ethanone (709-63-7) + Methyltriphenylphosphonium bromide (1779-49-3) → 4-trifluoromethyl-α-methylstyrene (55186-75-9)

Guidance literature:

Methyltriphenylphosphonium bromide; With n-butyllithium; In tetrahydrofuran; hexane; at 0 ℃; for 2h;

1-(4-trifluoromethylphenyl)ethanone; In tetrahydrofuran; hexane; at 0 - 70 ℃;

DOI:10.1002/anie.201410557

Reference yield: 81.0%

Isopropenyl acetate (108-22-5) + 4-chlorobenzotrifluoride (98-56-6) → 4-trifluoromethyl-α-methylstyrene (55186-75-9)

Guidance literature:

With [2,2]bipyridinyl; tetrabutylammonium tetrafluoroborate; cobalt(II) bromide; In pyridine; acetonitrile; at 20 ℃; Electrolysis;

DOI:10.1016/S0040-4020(03)00404-6

upstream raw materials:

1-(4-trifluoromethylphenyl)ethanone

Methyltriphenylphosphonium bromide

2-(4-(trifluoromethyl)phenyl)propan-2-ol

p-trifluoromethylphenyl bromide

Downstream raw materials:

formaldehyd

1-(4-trifluoromethylphenyl)ethanone

2-methyl-2-(4-(trifluoromethyl)phenyl)oxirane

2-(4-(trifluoromethyl)phenyl)propan-2-ol

Refernces

• 1、 Dong, Vy M.,Kuker, Erin L.,Lu, Alexander,Nie, Shaozhen. "Enantioselective Hydrothiolation: Diverging Cyclopropenes through Ligand Control". supporting information. p. 6176 - 6184. Retrieved 2021/05/07.
• 2、 Lou, Yixian,Qiu, Jian,Yang, Kai,Zhang, Feng,Wang, Chenglan,Song, Qiuling. "Ni-Catalyzed Reductive Allylation of α-Chloroboronates to Access Homoallylic Boronates". supporting information. p. 4564 - 4569. Retrieved 2021/06/28.