Methanone, (3-methoxyphenyl)-4-quinazolinyl-

Base Information

• Chemical Name: Methanone, (3-methoxyphenyl)-4-quinazolinyl-
• CAS No.: 55276-51-2
• Molecular Formula: C16H12N2O2
• Molecular Weight: 264.283
• DSSTox Substance ID: DTXSID60480162
• Nikkaji Number: J463.559K
• Wikidata: Q82314751
• Mol file: 55276-51-2.mol

Synonyms:55276-51-2;Methanone, (3-methoxyphenyl)-4-quinazolinyl-;DTXSID60480162

Chemical Property of Methanone, (3-methoxyphenyl)-4-quinazolinyl-

Chemical Property:

• XLogP3: 3.2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 3
• Exact Mass: 264.089877630
• Heavy Atom Count: 20
• Complexity: 347

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=CC(=C1)C(=O)C2=NC=NC3=CC=CC=C32

Technology Process of Methanone, (3-methoxyphenyl)-4-quinazolinyl-

There total 2 articles about Methanone, (3-methoxyphenyl)-4-quinazolinyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

4-chloroquinazoline (5190-68-1) + 3-methoxy-benzaldehyde (591-31-1) → (3-methoxy-phenyl)-quinazolin-4-yl-methanone (55276-51-2)

Guidance literature:

With 1,3-dimethylbenzimidazolium Iodide; sodium hydride; In tetrahydrofuran; for 1h; Heating;

DOI:10.1248/cpb.40.43

Reference yield:

→ (3-methoxy-phenyl)-quinazolin-4-yl-methanone (55276-51-2)

Guidance literature:

Chinazolin (I), m-Methoxybenzaldehyd, KCN, in wss. Me., Abtrennung durch Chromat.;

DOI:10.1248/cpb.22.2493

Reference yield: 59.0%

methyl magnesium iodide (917-64-6) + (3-methoxy-phenyl)-quinazolin-4-yl-methanone (55276-51-2) → 1-(3-methoxylphenyl)-1-(quinazolin-4-yl)ethanol

Guidance literature:

methyl magnesium iodide; (3-methoxy-phenyl)-quinazolin-4-yl-methanone; In tetrahydrofuran; diethyl ether; at 20 ℃; Inert atmosphere;

With water; ammonium chloride; In tetrahydrofuran; diethyl ether;

DOI:10.1021/ml5004684

upstream raw materials:

4-chloroquinazoline

3-methoxy-benzaldehyde