N-Phenyl-N-(1-(phenylmethyl)-4-piperidinyl)acetamide

Base Information

• Chemical Name: N-Phenyl-N-(1-(phenylmethyl)-4-piperidinyl)acetamide
• CAS No.: 1237-52-1
• Molecular Formula: C20H24 N2 O
• Molecular Weight: 308.423
• Hs Code.: 2933399090
• European Community (EC) Number: 214-979-9
• NSC Number: 73750
• UNII: PA9VPB673J
• DSSTox Substance ID: DTXSID50154067
• Nikkaji Number: J217.075B
• Wikidata: Q83021182
• Mol file: 1237-52-1.mol

Synonyms:1237-52-1;n-(1-benzylpiperidin-4-yl)-n-phenylacetamide;N-Phenyl-N-(1-(phenylmethyl)-4-piperidinyl)acetamide;1-Benzyl-4-(N-phenylacetamido)piperidine;PA9VPB673J;Acetamide, N-phenyl-N-[1-(phenylmethyl)-4-piperidinyl]-;EINECS 214-979-9;NSC-73750;Piperidine, 1-benzyl-4-(N-phenylacetamido)-;Acetamide, N-phenyl-N-(1-benzyl-4-piperidinyl)-;Acetamide, N-phenyl-N-(1-(phenylmethyl)-4-piperidinyl)-;N-PHENYL-N-[1-(PHENYLMETHYL)-4-PIPERIDINYL]ACETAMIDE;NSC73750;N-Benzyl acetyl fentanyl;UNII-PA9VPB673J;SCHEMBL6045443;DTXSID50154067;NSC 73750;AKOS024323081;N-(1-Benzyl-4-piperidinyl)-N-phenylacetamide;N-Phenyl-N-(1-benzyl-4-piperidinyl)acetamide;ACETANILIDE, N-(1-BENZYL-4-PIPERIDYL)-;N-(1-Benzyl-4-piperidinyl)-N-phenylacetamide #;N-(1-BENZYL-4-PIPERIDYL)-N-PHENYL-ACETAMIDE

Chemical Property of N-Phenyl-N-(1-(phenylmethyl)-4-piperidinyl)acetamide

Chemical Property:

• Vapor Pressure: 9.28E-08mmHg at 25°C
• Melting Point: 107-109.2 °C (decomp)
• Boiling Point: 434.7°Cat760mmHg
• PKA: 7.84±0.10(Predicted)
• Flash Point: 175.9°C
• PSA: 23.55000
• Density: 1.13g/cm³
• LogP: 3.64200
• XLogP3: 3.1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 4
• Exact Mass: 308.188863393
• Heavy Atom Count: 23
• Complexity: 364

Purity/Quality:

98%,99%, ^*data from raw suppliers

1-Benzyl-4-(N-phenylacetamido)piperidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(=O)N(C1CCN(CC1)CC2=CC=CC=C2)C3=CC=CC=C3
• Uses: 1-Benzyl-4-(N-phenylacetamido)piperidine is an impurity of Acetyl Fentanyl (A175000).

Technology Process of N-Phenyl-N-(1-(phenylmethyl)-4-piperidinyl)acetamide

There total 5 articles about N-Phenyl-N-(1-(phenylmethyl)-4-piperidinyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-benzyl-N-phenylpiperidin-4-amine (1155-56-2) + acetyl chloride (75-36-5) → N-(1-benzylpiperidin-4-yl)-N-phenylacetamide (1237-52-1)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 2h; Cooling with ice;

Reference yield:

acetic anhydride (108-24-7) + 1-benzyl-N-phenylpiperidin-4-amine (1155-56-2) → N-(1-benzylpiperidin-4-yl)-N-phenylacetamide (1237-52-1)

Guidance literature:

at 70 ℃;

Reference yield:

1-phenylmethyl-4-piperidone (3612-20-2) → N-(1-benzylpiperidin-4-yl)-N-phenylacetamide (1237-52-1)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium tris(acetoxy)borohydride / chloroform; ethyl acetate / 0.67 h / 20 °C

2: 70 °C

With sodium tris(acetoxy)borohydride; In chloroform; ethyl acetate;

upstream raw materials:

acetic anhydride

1-benzyl-N-phenylpiperidin-4-amine

acetyl chloride

1-phenylmethyl-4-piperidone

Refernces

• 1、 -. "RECEPTOR REGULATOR". Page/Page column 32. . Retrieved 2010/02/13.