2H-1-Benzopyran-4-methanol, 7-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-3-[4-[[(1,1-dimethylethyl)dimethyl silyl]oxy]-2-hydroxyphenyl]-a-[4-[2-(1-pyrrolidinyl)ethoxy]phenyl]-

Base Information

• Chemical Name: 2H-1-Benzopyran-4-methanol, 7-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-3-[4-[[(1,1-dimethylethyl)dimethyl silyl]oxy]-2-hydroxyphenyl]-a-[4-[2-(1-pyrrolidinyl)ethoxy]phenyl]-
• CAS No.: 554430-15-8
• Molecular Formula: C40H57NO6Si2
• Molecular Weight: 704.067
• Mol file: 554430-15-8.mol

Synonyms:

Chemical Property of 2H-1-Benzopyran-4-methanol, 7-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-3-[4-[[(1,1-dimethylethyl)dimethyl silyl]oxy]-2-hydroxyphenyl]-a-[4-[2-(1-pyrrolidinyl)ethoxy]phenyl]-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2H-1-Benzopyran-4-methanol, 7-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-3-[4-[[(1,1-dimethylethyl)dimethyl silyl]oxy]-2-hydroxyphenyl]-a-[4-[2-(1-pyrrolidinyl)ethoxy]phenyl]-

There total 5 articles about 2H-1-Benzopyran-4-methanol, 7-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-3-[4-[[(1,1-dimethylethyl)dimethyl silyl]oxy]-2-hydroxyphenyl]-a-[4-[2-(1-pyrrolidinyl)ethoxy]phenyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-[2-(4-iodophenoxy)ethyl]pyrrolidine (554430-67-0) + 2,8-bis(tert-butyl-dimethyl-silyloxy)-5,11-dihydro-chromeno[4,3-c]chromen-5-ol (553681-47-3) → 5-(tert-butyl-dimethyl-silyloxy)-2-(7-(tert-butyl-dimethyl-silyloxy)-4-{hydroxy-[4-(2-pyrroidine-1-yl-ethoxy)-phenyl]-methyl}-2H-chromen-3-yl)-phenol (554430-15-8)

Guidance literature:

1-[2-(4-iodophenoxy)ethyl]pyrrolidine; With isopropylmagnesium bromide; In tetrahydrofuran; diethyl ether; at -18 ℃; for 7h;

2,8-bis(tert-butyl-dimethyl-silyloxy)-5,11-dihydro-chromeno[4,3-c]chromen-5-ol; In tetrahydrofuran; diethyl ether; at -18 - 20 ℃; for 11h;

DOI:10.1021/jm060353u

Reference yield:

2,8-bis(tert-butyl-dimethyl-silyloxy)-11H-chromeno[4,3-c]chromen-5-one (554430-87-4) → 5-(tert-butyl-dimethyl-silyloxy)-2-(7-(tert-butyl-dimethyl-silyloxy)-4-{hydroxy-[4-(2-pyrroidine-1-yl-ethoxy)-phenyl]-methyl}-2H-chromen-3-yl)-phenol (554430-15-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: diisobutylaluminum hydride / toluene / 5 h / -78 °C

2.1: isopropylmagnesium bromide / tetrahydrofuran; diethyl ether / 7 h / -18 °C

2.2: tetrahydrofuran; diethyl ether / 11 h / -18 - 20 °C

With isopropylmagnesium bromide; diisobutylaluminium hydride; In tetrahydrofuran; diethyl ether; toluene;

DOI:10.1021/jm060353u

Reference yield:

tert-butyldimethylsilyl chloride (18162-48-6) → 5-(tert-butyl-dimethyl-silyloxy)-2-(7-(tert-butyl-dimethyl-silyloxy)-4-{hydroxy-[4-(2-pyrroidine-1-yl-ethoxy)-phenyl]-methyl}-2H-chromen-3-yl)-phenol (554430-15-8)

Guidance literature:

Multi-step reaction with 3 steps

1.1: Et₃N / CH₂Cl₂ / 18 h / 20 °C

2.1: diisobutylaluminum hydride / toluene / 5 h / -78 °C

3.1: isopropylmagnesium bromide / tetrahydrofuran; diethyl ether / 7 h / -18 °C

3.2: tetrahydrofuran; diethyl ether / 11 h / -18 - 20 °C

With isopropylmagnesium bromide; diisobutylaluminium hydride; triethylamine; In tetrahydrofuran; diethyl ether; dichloromethane; toluene;

DOI:10.1021/jm060353u

upstream raw materials:

1-[2-(4-iodophenoxy)ethyl]pyrrolidine

2,8-bis(tert-butyl-dimethyl-silyloxy)-5,11-dihydro-chromeno[4,3-c]chromen-5-ol

2,8-bis(tert-butyl-dimethyl-silyloxy)-11H-chromeno[4,3-c]chromen-5-one

tert-butyldimethylsilyl chloride

Downstream raw materials:

1-(2{-4-[2,8-bis-(tert-butyl-dimethyl-silyloxy)-5,11-dihydro-chromeno[4,3-c]-chromen-5-yl]-phenoxy}-ethyl)-pyrrolidine