Phenol, 3,5-dibromo-4-iodo-

Base Information

• Chemical Name: Phenol, 3,5-dibromo-4-iodo-
• CAS No.: 556038-75-6
• Molecular Formula: C6H3Br2IO
• Molecular Weight: 377.802
• Mol file: 556038-75-6.mol

Synonyms:

Chemical Property of Phenol, 3,5-dibromo-4-iodo-

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Phenol, 3,5-dibromo-4-iodo-

There total 8 articles about Phenol, 3,5-dibromo-4-iodo- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

methanesulfonic acid 3,5-dibromo-4-iodophenyl ester (556038-74-5) → 3,5-dibromo-4-iodophenyjl (556038-75-6)

Guidance literature:

With potassium hydroxide; In methanol; dichloromethane; at 23 ℃; for 0.0833333h;

DOI:10.1021/ja035303i

Reference yield: 76.0%

1,3-dibromo-2-iodo-5-methoxybenzene (201161-11-7) → 3,5-dibromo-4-iodophenyjl (556038-75-6)

Guidance literature:

With boron tribromide; In dichloromethane; at 20 ℃; for 48h;

DOI:10.1021/ja904481j

Reference yield:

p-nitrophenyl methanesulfonate (20455-07-6) → 3,5-dibromo-4-iodophenyjl (556038-75-6)

Guidance literature:

Multi-step reaction with 4 steps

1.1: 100 percent / H₂ / Ra-Ni / ethyl acetate; ethanol / 24 h / 23 °C / 72400.7 Torr

2.1: 94.5 g / Br₂ / methanol; CH₂Cl₂ / 0.5 h / 0 - 23 °C

3.1: aq. NaNO₂; H₂SO₄ / acetonitrile / 0 °C

3.2: 96 percent / aq. KI / acetonitrile / 0.75 h

4.1: 100 percent / KOH / CH₂Cl₂; methanol / 0.08 h / 23 °C

With potassium hydroxide; sulfuric acid; hydrogen; bromine; sodium nitrite; Ra-Ni; In methanol; ethanol; dichloromethane; ethyl acetate; acetonitrile;

DOI:10.1021/ja035303i

upstream raw materials:

methanesulfonic acid 3,5-dibromo-4-iodophenyl ester

1,3-dibromo-5-(trimethylsilyloxy)benzene

3,5-dibromophenol

p-nitrophenyl methanesulfonate

Downstream raw materials:

1,3-dibromo-2-iodo-5-methoxybenzene

duocarmycin A

(+)-duocarmycin SA

(2S)-2-(4-benzyloxy-2,6-dibromophenyl)-3-nitropropan-1-ol