1-Propanone, 1-phenyl-2-[(trimethylsilyl)oxy]-

Base Information

• Chemical Name: 1-Propanone, 1-phenyl-2-[(trimethylsilyl)oxy]-
• CAS No.: 55638-25-0
• Molecular Formula: C12H18O2Si
• Molecular Weight: 222.359
• DSSTox Substance ID: DTXSID80480982
• Nikkaji Number: J1.680.622F
• Mol file: 55638-25-0.mol

Synonyms:55638-25-0;1-Propanone, 1-phenyl-2-[(trimethylsilyl)oxy]-;DTXSID80480982

Chemical Property of 1-Propanone, 1-phenyl-2-[(trimethylsilyl)oxy]-

Chemical Property:

• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 4
• Exact Mass: 222.107606347
• Heavy Atom Count: 15
• Complexity: 214

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C(=O)C1=CC=CC=C1)O[Si](C)(C)C

Technology Process of 1-Propanone, 1-phenyl-2-[(trimethylsilyl)oxy]-

There total 8 articles about 1-Propanone, 1-phenyl-2-[(trimethylsilyl)oxy]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

phenyl trimethylsilyl selenide (33861-17-5) + 1-Phenylpropane-1,2-dione (579-07-7) → 1-phenyl-2-(trimethylsilyloxy)propan-1-one (55638-25-0) + methyl(α-trimethylsiloxybenzyl) ketone (26205-40-3)

Guidance literature:

With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; In benzene; at 80 ℃;

DOI:10.1021/ol0162567

Reference yield:

1-phenyl-1-trimethylsiloxypropene (37471-46-8) → 1-phenyl-2-(trimethylsilyloxy)propan-1-one (55638-25-0) + 1-phenyl-propan-1-one (93-55-0) + 1-Phenylpropane-1,2-dione (579-07-7)

Guidance literature:

With oxygen; In water; toluene; at 80 ℃; for 11h; under 760.051 Torr; Time; Temperature;

DOI:10.1016/j.tet.2014.05.014

Reference yield:

1-phenyl-1-trimethylsiloxypropene (37471-46-8) → 1-phenyl-2-(trimethylsilyloxy)propan-1-one (55638-25-0) + 2-hydroxypropiophenone (5650-40-8) + 1-phenyl-propan-1-one (93-55-0) + 1-Phenylpropane-1,2-dione (579-07-7)

Guidance literature:

With oxygen; In water; toluene; at 60 ℃; for 15h; under 760.051 Torr; Time; Solvent;

DOI:10.1016/j.tet.2014.05.014

upstream raw materials:

1-phenyl-1-trimethylsiloxypropene

acetaldehyde

phenyl trimethylsilyl selenide

1-Phenylpropane-1,2-dione

Downstream raw materials:

(2R,3R)-2-Phenyl-3-trimethylsilanyloxy-butan-2-ol

(2R,3S)-2-Phenyl-3-trimethylsilanyloxy-butan-2-ol

(R^*,S^*)-2-phenyl-3-<(trimethylsilyl)oxy>-2-butanol

benzaldehyde