5-Methyloxazolo[4,5-b]pyridine-2-thiol

Base Information

• Chemical Name: 5-Methyloxazolo[4,5-b]pyridine-2-thiol
• CAS No.: 55656-32-1
• Molecular Formula: C₇H₆N₂OS
• Molecular Weight: 166.203
• European Community (EC) Number: 853-897-3
• DSSTox Substance ID: DTXSID70506140
• Wikidata: Q82361740
• Mol file: 55656-32-1.mol

Synonyms:55656-32-1;5-Methyloxazolo[4,5-b]pyridine-2-thiol;5-methyl[1,3]oxazolo[4,5-b]pyridine-2-thiol;5-methyl-3H-[1,3]oxazolo[4,5-b]pyridine-2-thione;5-methyl-[1,3]oxazolo[4,5-b]pyridine-2-thiol;SCHEMBL778983;DTXSID70506140;MGXUVVBOGPSKRQ-UHFFFAOYSA-N;MFCD11053024;AKOS005174663;AKOS030229788;AS-48566;5-Methloxazolo[4,5-b]pyridin-2(3H)-thione;5-methyl-3h-oxazolo[4,5-b]pyridine-2-thione;5-Methyloxazolo[4,5-b]pyridine-2(3H)-thione;EN300-132376;F51231;A913321;5-Methyl[1,3]oxazolo[4,5-b]pyridine-2(3H)-thione;Z1198309540

Chemical Property of 5-Methyloxazolo[4,5-b]pyridine-2-thiol

Chemical Property:

• PSA: 77.72000
• LogP: 1.81990
• XLogP3: 1.4
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 0
• Exact Mass: 166.02008399
• Heavy Atom Count: 11
• Complexity: 185

Purity/Quality:

97% ^*data from raw suppliers

5-methyl[1,3]oxazolo[4,5-b]pyridine-2-thiol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC1=NC2=C(C=C1)OC(=S)N2

Technology Process of 5-Methyloxazolo[4,5-b]pyridine-2-thiol

There total 7 articles about 5-Methyloxazolo[4,5-b]pyridine-2-thiol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

potassium ethyl xanthogenate (140-89-6) + 2-amino-3-hydroxy-6-methylpyridine (20348-16-7) → 5-Methyl-3H-oxazolo<4,5-b>pyridine-2-thione (55656-32-1)

Guidance literature:

In ethanol; for 6h;

DOI:10.1007/BF00505683

Reference yield: 85.0%

carbon disulfide (75-15-0,12122-00-8) + 2-amino-3-hydroxy-6-methylpyridine (20348-16-7) → 5-methyloxazolo[4,5-b]pyridine-2-thiol (55656-32-1)

Guidance literature:

carbon disulfide; 2-amino-3-hydroxy-6-methylpyridine; With potassium hydroxide; In ethanol; for 16h; Heating / reflux;

With acetic acid; In water; pH=5;

Reference yield: 77.0%

potassium ethyl xanthogenate (140-89-6) + 2-amino-3-hydroxy-6-methylpyridine (20348-16-7) → 5-methyloxazolo[4,5-b]pyridine-2-thiol (55656-32-1)

Guidance literature:

In ethanol; at 80 ℃; for 4h;

upstream raw materials:

potassium ethyl xanthogenate

2-amino-3-hydroxy-6-methylpyridine

carbon disulfide

6-methyl-2-nitropyridin-3-ol

Downstream raw materials:

1-Cyclohexyl-3-(3-hydroxy-6-methyl-pyridin-2-yl)-thiourea

N-(6-Methyl-3-hydroxy-2-pyridyl)-N-benzylthiourea