20348-16-7

Usage

Uses

Used in Pharmaceutical Industry:
2-amino-6-methylpyridin-3-ol is used as a drug development candidate for treating various diseases, including cancer, inflammation, and neurodegenerative disorders. Its chemical structure allows for interactions with biological targets, offering therapeutic benefits.
Used in Organic Synthesis:
2-amino-6-methylpyridin-3-ol serves as a building block in the synthesis of other organic compounds, contributing to the creation of novel molecules with diverse applications in research and industry. Its reactivity and functional groups make it a valuable component in chemical reactions and molecular assembly.

InChI:InChI=1/C6H8N2O/c1-4-2-3-5(9)6(7)8-4/h2-3,9H,1H3,(H2,7,8)

Upstream product

• 15128-90-2 6-methyl-2-nitropyridin-3-ol 
• 1121-78-4 5-Hydroxy-2-methylpyridine 

Downstream Products

• 55656-32-1 5-Methyl-3H-oxazolo<4,5-b>pyridine-2-thione 
• 134377-98-3 2-(2-fluorophenyl)-5-methyloxazolo[4,5-b]pyridine 
• 20348-10-1 6-methyl-2H-pyrido[3,2-b]-1,4-oxazin-3(4h)-one 
• 209328-87-0 2-fluoro-6-methylpyridin-3-ol 
• 55656-32-1 5-methyloxazolo[4,5-b]pyridine-2-thiol 
• 55656-25-2 5-METHYL-3H-OXAZOLO[4,5-b]-PYRIDIN-2-ONE 
• 1355026-63-9 C₁₄H₁₀Cl₂N₂O₂ 
• 1355026-42-4 C₁₄H₁₄Cl₂N₂O₂ 
• 1564284-01-0 5-methyl-N-(4-(trifluoromethyl)phenyl)oxazolo[4,5-b]pyridin-2-amine 
• 1564284-07-6 N-cyclohexyl-5-methyloxazolo[4,5-b]pyridin-2-amine 
• 1564283-89-1 5-methyl-N-phenyloxazolo[4,5-b]pyridin-2-amine 
• 1564283-91-5 N-(4-fluorophenyl)-5-methyloxazolo[4,5-b]pyridin-2-amine 
• 1564283-93-7 N-(4-chlorophenyl)-5-methyloxazolo[4,5-b]pyridin-2-amine 
• 1564284-03-2 N-(4-chloro-3-(trifluoromethyl)phenyl)-5-methyloxazolo[4,5-b]pyridin-2-amine 

Relevant academic research and scientific papers

Targeting cyclic nucleotide phosphodiesterase 5 (PDE5) in brain: Toward the development of a PET radioligand labeled with fluorine-18

With the aim to develop a specific radioligand for imaging the cyclic nucleotide phosphodiesterase 5 (PDE5) in brain by positron emission tomography (PET), seven new fluorinated inhibitors (3–9) were synthesized on the basis of a quinoline core. The inhibitory activity for PDE5 together with a panel of other PDEs was determined in vitro and two derivatives were selected for IC50 value determination. The most promising compound 7 (IC50 = 5.92 nM for PDE5A), containing a 3-fluoroazetidine moiety, was further radiolabeled by aliphatic nucleophilic substitution of two different leaving groups (nosylate and tosylate) using [18F]fluoride. The use of the nosylate precursor and tetra-n-butyl ammonium [18F]fluoride ([18F]TBAF) in 3-methyl-3-pentanol combined with the addition of a small amount of water proved to be the best radiolabeling conditions achieving a RCY of 4.9 ± 1.5% in an automated procedure. Preliminary biological investigations in vitro and in vivo were performed to characterize this new PDE5 radioligand. Metabolism studies of [18F]7 in mice revealed a fast metabolic degradation with the formation of radiometabolites which have been detected in the brain.

ANTIPRURITIC AGENT

An antipruritic which exerts an antipruritic effect based on a novel action mechanism and is effective for pruritus. The antipruritic contains as an effective ingredient a compound which activates a central type nicotinic acetylcholine receptor.

HARMFUL ARTHROPOD CONTROL COMPOSITION, AND FUSED HETEROCYCLIC COMPOUND

Disclosed is a harmful arthropod control composition comprising, as an active ingredient, a fused heterocyclic compound represented by formula (1) [wherein A1 and A2 independently represent a nitrogen atom or the like; R1 and R4 independently represent a halogen atom or the like; R2 and R3 independently represent a halogen atom or the like; R5 and R6 independently represent a linear C1-C6 hydrocarbon group which may be substituted, or the like (provided that both R5 and R6 cannot represent a hydrogen atom simultaneously); and n represents 0 or 1]. The harmful arthropod control composition has an excellent efficacy to control harmful arthropods.

HARMFUL ARTHROPOD CONTROL COMPOSITION, AND FUSED HETEROCYCLIC COMPOUND

Disclosed is a harmful arthropod control composition comprising, as an active ingredient, a fused heterocyclic compound represented by formula (1) [wherein A1 and A2 independently represent a nitrogen atom or the like; R1 and R4 independently represent a halogen atom or the like; R2 and R3 independently represent a halogen atom or the like; R5 and R6 independently represent a linear C1-C6 hydrocarbon group which may be substituted, or the like (provided that both R5 and R6 cannot represent a hydrogen atom simultaneously); and n represents 0 or 1]. The harmful arthropod control composition has an excellent efficacy to control harmful arthropods.

COMPOSITION AND METHOD FOR CONTROLLING ARTHROPOD PESTS

The present invention provides: an arthropod pests control composition comprising, as active ingredients, a condensed heterocyclic compound and a neonicotinoid compound; a method for controlling arthropod pests which comprises applying effective amounts of a condensed heterocyclic compound and a neonicotinoid compound to the arthropod pests or a locus where the arthropod pests inhabit; and so on.

COMPOSITION AND METHOD FOR CONTROLLING ARTHROPOD PESTS

The present invention provides: an arthropod pests control composition comprising, as active ingredients, a condensed heterocyclic compound and pyriproxyfen; a method for controlling arthropod pests which comprises applying effective amounts of a condensed heterocyclic compound and pyriproxyfen to the arthropod pests or a locus where the arthropod pests inhabit; and so on.

COMPOSITION AND METHOD FOR CONTROLLING ARTHROPOD PESTS

The present invention provides: an arthropod pests control composition comprising, as active ingredients, a condensed heterocyclic compound and a pyrethroid compound; a method for controlling arthropod pests which comprises applying effective amounts of a condensed heterocyclic compound and a pyrethroid compound to the arthropod pests or a locus where the arthropod pests inhabit; and so on.

COMPOSITION AND METHOD FOR CONTROLLING ARTHROPOD PESTS

The present invention provides: an arthropod pests control composition comprising, as active ingredients, a condensed heterocyclic compound and pyridalyl; a method for controlling arthropod pests which comprises applying effective amounts of a condensed heterocyclic compound and pyridalyl to the arthropod pests or a locus where the arthropod pests inhabit; and so on.

COMPOSITION AND METHOD FOR CONTROLLING ARTHROPOD PESTS

The present invention provides: an arthropod pests control composition comprising, as active ingredients, a condensed heterocyclic compound and a diamide compound; a method for controlling arthropod pests which comprises applying effective amounts of a condensed heterocyclic compound and a diamide compound to the arthropod pests or a locus where the arthropod pests inhabit; and so on.

2-OXO-3-BENZYLBENZOXAZOL-2-ONE DERIVATIVES AND RELATED COMPOUNDS AS MET KINASE INHIBITORS FOR THE TREATMENT OF TUMOURS

Compounds of the formula (I), in which R1, R2, R3, R3′, R4, R4′, E, E′, E″ and E′″ have the meanings indicated in Claim 1, are inhibitors of tyrosine kinases, in particular Met kinase, and can be employed, inter alia, for the treatment of tumours.