Di(2-thiazolyl)Methanone

Base Information

• Chemical Name: Di(2-thiazolyl)Methanone
• CAS No.: 55707-55-6
• Molecular Formula: C7H4N2OS2
• Molecular Weight: 196.24900
• Mol file: 55707-55-6.mol

Synonyms:Tetrahydro-4H-pyran-2-yl-ether;bis-tetrahydropyran-2-yl ether;bis-thiazol-2-yl-methanone;mono-tetrahydropyranyl ether;bis-tetrahydrothiopyran-4-ylidene-hydrazine;Thiacyclohexan-4-on-azin;tetrahydro-4H-thiopyran-4-on azine;Bis-tetrahydropyran-2-yl-aether;

Chemical Property of Di(2-thiazolyl)Methanone

Chemical Property:

• Melting Point: 140-141 °C (decomp)
• Boiling Point: 364.8±25.0 °C(Predicted)
• PKA: -0.75±0.10(Predicted)
• PSA: 99.33000
• Density: 1.476±0.06 g/cm3(Predicted)
• LogP: 1.83060
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

Di(2-thiazolyl)methanone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Di(2-thiazolyl)Methanone

There total 5 articles about Di(2-thiazolyl)Methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

N-aniline (123209-19-8) → di(1,3-thiazol-2-yl) ketone (55707-55-6)

Guidance literature:

With hydrogenchloride; In methanol;

DOI:10.1021/jo00287a028

Reference yield: 38.0%

Thiazole-2-carbaldehyde (10200-59-6) + 2-(trimethylsilyl)thiazole (79265-30-8) → di(1,3-thiazol-2-yl) ketone (55707-55-6)

Guidance literature:

In dichloromethane; for 18h; Ambient temperature;

DOI:10.1021/jo00243a029

Reference yield: 18.0%

2-lithiothiazole (40610-14-8) + N-Ethoxycarbonyl-1,3-thiazolium chloride (93472-12-9) → di(1,3-thiazol-2-yl) ketone (55707-55-6)

Guidance literature:

DOI:10.1016/S0040-4039(01)91095-0

upstream raw materials:

Thiazole-2-carbaldehyde

2-(trimethylsilyl)thiazole

2-lithiothiazole

N-Ethoxycarbonyl-1,3-thiazolium chloride

Refernces

• 1、 Dondoni, Alessandro,Fantin, Giancarlo,Fogagnolo, Marco,Medici, Alessandro,Pedrini, Paola. "Synthesis of (Trimethylsilyl)thiazoles and Reactions with Carbonyl Compounds. Selectivity Aspects and Synthetic Utility". . p. 1748 - 1761. Retrieved 2007/10/02.