10200-59-6

Usage

Uses

Used in Pharmaceutical Industry:
1,3-Thiazole-2-carbaldehyde is used as a building block for the synthesis of taxane analogs, which are important in the development of various pharmaceutical compounds. Its unique chemical properties make it a valuable component in the creation of these analogs, contributing to the advancement of drug discovery and development.
The provided materials do not mention any other specific applications or industries for 1,3-Thiazole-2-carbaldehyde. However, based on its role as a building block for taxane analogs, it can be inferred that 1,3-Thiazole-2-carbaldehyde may have potential applications in the development of anticancer drugs and other therapeutic agents. Further research and development in the pharmaceutical industry could potentially reveal additional uses for this versatile compound.

Synthesis Reference(s)

Synthesis, p. 998, 1987 DOI: 10.1055/s-1987-28146

InChI:InChI=1/C4H3NOS/c6-3-4-5-1-2-7-4/h1-3H

Upstream product

• 96-50-4 2-thiazolylamine 
• 75-17-2 formaldoxime 
• 14542-12-2 (1,3-thiazol-2-yl)methanol 
• 40610-14-8 2-lithiothiazole 
• 68-12-2 N,N-dimethyl-formamide 
• 3034-53-5 2-bromo-1,3-thiazole 
• 4394-85-8 4-morpholinecarboxaldehyde 
• 54101-88-1 thiazolo<3,2-c><1,2,3>triazole 
• 134271-22-0 2-Dibromomethylthiazole 
• 288-47-1 1,3-thiazole 
• 2591-86-8 N-Formylpiperidine 
• 16733-85-0 thiazole-2-carboxamide 

Downstream Products

• 13838-75-0 N-thiazol-2-ylmethylene-aniline 
• 86213-31-2 (E)-2-phenyl-3-(2-thiazolyl)acrylic acid 
• 86213-32-3 (Z)-2-phenyl-3-(2-thiazolyl)acrylic acid 
• 52396-77-7 3-thiazol-2-yl-acrylic acid 
• 55707-55-6 di(1,3-thiazol-2-yl) ketone 
• 144163-68-8 2-<(N-methylamino)methyl>thiazole 
• 101041-83-2 2-Methyl-5-oxo-4-thiazol-2-yl-1,4,5,6,7,8-hexahydro-quinoline-3-carboxylic acid 2-(benzyl-methyl-amino)-ethyl ester 
• 143896-78-0 C₁₁H₁₁N₃O₂S₂ 
• 14542-12-2 (1,3-thiazol-2-yl)methanol 
• 129974-01-2 Hydrazone of 2-thiazolecarboxaldehyde 
• 162365-53-9 (Z)-N-(2-thiazolyl)methylenebenzylamine N-oxide 
• 24295-04-3 2-(1,3-dioxolan-2-yl)-1,3-thiazole 
• 917-23-7 5,15,10,20-tetraphenylporphyrin 
• 882690-75-7 N-benzyl-1-(thiazol-2-yl)methanimine 

Relevant academic research and scientific papers

Facile preparation and reactivity of polymer-supported N-(2-lodyl-phenyl)- acylamide, an Efficient Oxidizing System

(Chemical Equation Presented) A simple three-step preparation of polymer-supported N-(2-iodyl-phenyl)-acylamide (NIPA resin) starting from 2-iodoaniline is described. The resin was obtained with good loading levels (0.7-0.8 mmol g-1) and has been successfully used for efficient oxidation of a diverse collection of alcohols. Thus, treating alcohols with 1.0 equiv of the resin in 1,2-dichloroethane under reflux for 30-60 min allowed rapid and in most cases complete conversion to the corresponding carbonyl compound.

Selective metallation of thiophene and thiazole rings with magnesium amide base

The chemoselective magnesiation of thiophene and thiazole derivatives were reported using magnesium chloride. Organomagnesium compounds were used at relatively higher temperatures. The results showed that hydrogen-magnesium exchange reaction of thiophene derivatives with iPr2NMgCl proceeded selectively.

Conjugated compounds based on vinylthiazole units

Conjugated compounds based on vinylthiazole units show a strong polarization along the π chain, when NR2 groups as electron donors are attached in the terminal position. The effect can be even more enhanced by a CHO group as electron acceptor in the opposite terminal position. This property makes such oligomers (n = 1, 2, . . .) interesting for applications in linear and nonlinear optics.

Synthesis of nonlinear optical chromophores containing electron-excessive and -deficient heterocyclic bridges. The auxiliary donor-acceptor effects

Push-pull substituted nonlinear optical chromophores with thiazole and thiophene rings and interposed ethylene units as π-conjugated bridges were synthesized. The effects of the nature and location of the heterocycles on the energy of the charge transfer transition for the chromophores are discussed.

INHIBITORS OF INFLUENZA VIRUS REPLICATION AND USES THEREOF

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A general approach towards synthesis of 2(5)-hydroxyalkyl-substituted 1,3-thiazole derivatives has been proposed. The method includes lithiation of 1,3-thiazole ring followed by reacting the formed thiazole lithium derivatives with electrophiles.

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