1-(4-Chlorophenylsulfonyl)-5-fluorouracil

Base Information

Chemical Name:1-(4-Chlorophenylsulfonyl)-5-fluorouracil
CAS No.:56059-14-4
Molecular Formula:C10H6ClFN2O4S
Molecular Weight:304.686
Hs Code.:
DSSTox Substance ID:DTXSID70439040
Nikkaji Number:J562.743E
Wikidata:Q82254915

Synonyms:56059-14-4;1-(4-Chlorophenylsulfonyl)-5-fluorouracil;1-(4-chlorophenyl)sulfonyl-5-fluoropyrimidine-2,4-dione;SCHEMBL11808443;DTXSID70439040

Suppliers and Price of 1-(4-Chlorophenylsulfonyl)-5-fluorouracil

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Total 0 raw suppliers

Chemical Property of 1-(4-Chlorophenylsulfonyl)-5-fluorouracil

Chemical Property:

XLogP3:1.3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:2
Exact Mass:303.9720837
Heavy Atom Count:19
Complexity:534

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC(=CC=C1S(=O)(=O)N2C=C(C(=O)NC2=O)F)Cl

Technology Process of 1-(4-Chlorophenylsulfonyl)-5-fluorouracil

There total 2 articles about 1-(4-Chlorophenylsulfonyl)-5-fluorouracil which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

: 51-21-8
5-fluorouracil

: 98-60-2
4-chlorobenzenesulfonyl chloride

: 56059-14-4
1-(4-chlorophenylsulfonyl)-5-fluorouracil

Guidance literature:: With triethylamine; In N,N-dimethyl acetamide; Ambient temperature;
DOI:10.1002/jhet.5570310213

Reference yield:

: 56059-14-4
1-(4-chlorophenylsulfonyl)-5-fluorouracil

Guidance literature:: 5-Fluoruracil, p-Chlorbenzolsulfonylchlorid;

Reference yield: 44.5%

: 56059-14-4
1-(4-chlorophenylsulfonyl)-5-fluorouracil

: 3068-31-3
1-bromo-2,3,4-tri-O-acetyl-α-D-xylopyranose

: Acetic acid (2R,3R,4S,5R)-4,5-diacetoxy-2-[3-(4-chloro-benzenesulfonyl)-5-fluoro-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl]-tetrahydro-pyran-3-yl ester

Guidance literature:: With sodium hydroxide; tetrabutylammomium bromide; In chloroform; water; at 55 ℃; for 2.5h; pH=8 - 10;
DOI:10.1081/SCC-100000181