2-(α-Hydroxybenzyl)cyclohexanone

Base Information

• Chemical Name: 2-(α-Hydroxybenzyl)cyclohexanone
• CAS No.: 56072-25-4
• Molecular Formula: C13H16O2
• Molecular Weight: 204.269
• Mol file: 56072-25-4.mol

Synonyms:2-(1-hydroxy-1-phenylmethyl)cyclohexan-1-one;(rel)-(R)-2-[(R)-hydroxy(phenyl)methyl]cyclohexanone;2-(HYDROXY-PHENYL-METHYL)-CYCLOHEXANONE;(2RS,1'RS)-2-[hydroxy-(phenyl)methyl]cyclohexan-1-one;2-[1-hydroxy-1-(phenyl)methyl]cyclohexan-1-one;(2RS)-2-[(RS)-hydroxy-(phenyl)methyl]cyclohexan-1-one;(R,S)-2-[(R,S)-hydroxy(phenyl)methyl]cyclohexan-1-one;

Chemical Property of 2-(α-Hydroxybenzyl)cyclohexanone

Chemical Property:

• PSA: 37.30000
• LogP: 2.47930

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(α-Hydroxybenzyl)cyclohexanone

There total 125 articles about 2-(α-Hydroxybenzyl)cyclohexanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

cyclohexanone (108-94-1,11119-77-0,9003-41-2,9075-99-4) + benzaldehyde (100-52-7) → 2-(hydroxyphenylmethyl)cyclohexan-1-one (13161-18-7,42052-56-2,66607-57-6,66607-58-7,56072-25-4)

Guidance literature:

With aluminum oxide; 1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine; In toluene; at 20 ℃; for 0.75h; Sonication;

DOI:10.1039/c2ob06648c

Reference yield: 95.0%

cyclohexanone (108-94-1,11119-77-0,9003-41-2,9075-99-4) + benzaldehyde (100-52-7) → 2‐(hydroxy(phenyl)methyl)cyclohexan‐1‐one (56072-25-4) + (2S)-2-[(R)-hydroxy(phenyl)methyl]cyclohexan-1-one (156039-16-6)

Guidance literature:

cyclohexanone; With formic acid; C₆₆H₆₃N₁₅O₆; benzoic acid; In water; at 20 ℃; for 0.5h; Inert atmosphere; Green chemistry;

benzaldehyde; In water; at 20 ℃; for 72h; Overall yield = 77 %; Overall yield = 15.7 mg; stereoselective reaction; Inert atmosphere; Green chemistry;

DOI:10.1002/adsc.201200856

Reference yield: 94.0%

1-(Trimethylsilyloxy)cyclohexene (6651-36-1) + benzaldehyde (100-52-7) → 2-(hydroxyphenylmethyl)cyclohexan-1-one (13161-18-7,42052-56-2,66607-57-6,66607-58-7,56072-25-4)

Guidance literature:

With calix[6]arene; scandium tris(trifluoromethanesulfonate); In water; at 20 ℃; for 4h;

DOI:10.1016/S0040-4039(00)00257-4

upstream raw materials:

cyclohexanone

benzaldehyde

2-(1-Hydroxy-2-methylpropyl)cyclohexanone

1-(Trimethylsilyloxy)cyclohexene

Downstream raw materials:

2-Benzylidenecyclohexanone

2-(α-Hydroxy-benzyl)-1-phenyl-cyclohexanol

(E)-2-benzylidenecyclohexanone

2,6-bis(phenylmethylene)cyclohexanone