Benzeneacetamide, N-[2-[(2-hydroxy-2-phenylethyl)amino]-1-methylethyl]-

Base Information

• Chemical Name: Benzeneacetamide, N-[2-[(2-hydroxy-2-phenylethyl)amino]-1-methylethyl]-
• CAS No.: 56203-39-5
• Molecular Formula: C19H24N2O2
• Molecular Weight: 312.412
• Mol file: 56203-39-5.mol

Synonyms:

Chemical Property of Benzeneacetamide, N-[2-[(2-hydroxy-2-phenylethyl)amino]-1-methylethyl]-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Benzeneacetamide, N-[2-[(2-hydroxy-2-phenylethyl)amino]-1-methylethyl]-

There total 5 articles about Benzeneacetamide, N-[2-[(2-hydroxy-2-phenylethyl)amino]-1-methylethyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-{2-[Benzyl-(2-hydroxy-2-phenyl-ethyl)-amino]-1-methyl-ethyl}-2-phenyl-acetamide → 2-{[2-(phenylacetamido)propyl]amino}-1-phenylethanol (56203-39-5)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol; Yield given; Ambient temperature;

DOI:10.1021/jm00176a002

Reference yield:

2-benzylamino-1-phenyl-ethanol (51096-49-2,91579-12-3,107171-75-5,27159-30-4) → 2-{[2-(phenylacetamido)propyl]amino}-1-phenylethanol (56203-39-5)

Guidance literature:

Multi-step reaction with 5 steps

1: KI / acetonitrile / 1.5 h / Heating

2: hydroxylamine hydrochloride, K₂CO₃ / ethanol; H₂O / 2 h / Heating

3: sodium bis(2-methoxyethoxy)aluminum hydride / benzene; toluene / 18 h / Ambient temperature

4: Et₃N / toluene / 0.5 h

5: H₂ / 30percent Pd/C / ethanol / Ambient temperature

With hydroxylamine hydrochloride; hydrogen; potassium carbonate; triethylamine; sodium bis(2-methoxyethoxy)aluminium dihydride; potassium iodide; palladium on activated charcoal; In ethanol; water; toluene; acetonitrile; benzene;

DOI:10.1021/jm00176a002

Reference yield:

1-[Benzyl-(2-hydroxy-2-phenyl-ethyl)-amino]-propan-2-one (56203-53-3) → 2-{[2-(phenylacetamido)propyl]amino}-1-phenylethanol (56203-39-5)

Guidance literature:

Multi-step reaction with 4 steps

1: hydroxylamine hydrochloride, K₂CO₃ / ethanol; H₂O / 2 h / Heating

2: sodium bis(2-methoxyethoxy)aluminum hydride / benzene; toluene / 18 h / Ambient temperature

3: Et₃N / toluene / 0.5 h

4: H₂ / 30percent Pd/C / ethanol / Ambient temperature

With hydroxylamine hydrochloride; hydrogen; potassium carbonate; triethylamine; sodium bis(2-methoxyethoxy)aluminium dihydride; palladium on activated charcoal; In ethanol; water; toluene; benzene;

DOI:10.1021/jm00176a002

upstream raw materials:

2-benzylamino-1-phenyl-ethanol

1-[Benzyl-(2-hydroxy-2-phenyl-ethyl)-amino]-propan-2-one

1-[Benzyl-(2-hydroxy-2-phenyl-ethyl)-amino]-propan-2-one oxime

2--1-phenylethanol