1-[Benzyl-(2-hydroxy-2-phenyl-ethyl)-amino]-propan-2-one oxime

Base Information

• Chemical Name: 1-[Benzyl-(2-hydroxy-2-phenyl-ethyl)-amino]-propan-2-one oxime
• CAS No.: 56203-54-4
• Molecular Formula: C₁₈H₂₂N₂O₂
• Molecular Weight: 298.385
• Mol file: 56203-54-4.mol

Synonyms:1-[Benzyl-(2-hydroxy-2-phenyl-ethyl)-amino]-propan-2-one oxime

Chemical Property of 1-[Benzyl-(2-hydroxy-2-phenyl-ethyl)-amino]-propan-2-one oxime

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-[Benzyl-(2-hydroxy-2-phenyl-ethyl)-amino]-propan-2-one oxime

There total 2 articles about 1-[Benzyl-(2-hydroxy-2-phenyl-ethyl)-amino]-propan-2-one oxime which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-[Benzyl-(2-hydroxy-2-phenyl-ethyl)-amino]-propan-2-one (56203-53-3) → 1-[Benzyl-(2-hydroxy-2-phenyl-ethyl)-amino]-propan-2-one oxime (56203-54-4)

Guidance literature:

With hydroxylamine hydrochloride; potassium carbonate; In ethanol; water; for 2h; Heating;

DOI:10.1021/jm00176a002

Reference yield:

2-benzylamino-1-phenyl-ethanol (51096-49-2,91579-12-3,107171-75-5,27159-30-4) → 1-[Benzyl-(2-hydroxy-2-phenyl-ethyl)-amino]-propan-2-one oxime (56203-54-4)

Guidance literature:

Multi-step reaction with 2 steps

1: KI / acetonitrile / 1.5 h / Heating

2: hydroxylamine hydrochloride, K₂CO₃ / ethanol; H₂O / 2 h / Heating

With hydroxylamine hydrochloride; potassium carbonate; potassium iodide; In ethanol; water; acetonitrile;

DOI:10.1021/jm00176a002

Reference yield:

1-[Benzyl-(2-hydroxy-2-phenyl-ethyl)-amino]-propan-2-one oxime (56203-54-4) → 2-{[2-(phenylacetamido)propyl]amino}-1-phenylethanol (56203-39-5)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium bis(2-methoxyethoxy)aluminum hydride / benzene; toluene / 18 h / Ambient temperature

2: Et₃N / toluene / 0.5 h

3: H₂ / 30percent Pd/C / ethanol / Ambient temperature

With hydrogen; triethylamine; sodium bis(2-methoxyethoxy)aluminium dihydride; palladium on activated charcoal; In ethanol; toluene; benzene;

DOI:10.1021/jm00176a002

upstream raw materials:

1-[Benzyl-(2-hydroxy-2-phenyl-ethyl)-amino]-propan-2-one

2-benzylamino-1-phenyl-ethanol

Downstream raw materials:

2--1-phenylethanol

2-{[2-(phenylacetamido)propyl]amino}-1-phenylethanol