Benzenamine, N,N-diethyl-4-(4-pyridinylethynyl)-

Base Information

Chemical Name:Benzenamine, N,N-diethyl-4-(4-pyridinylethynyl)-
CAS No.:562813-17-6
Molecular Formula:C17H18N2
Molecular Weight:250.343
Hs Code.:
DSSTox Substance ID:DTXSID20462000
Nikkaji Number:J1.914.264G

Synonyms:562813-17-6;Benzenamine, N,N-diethyl-4-(4-pyridinylethynyl)-;N,N-Diethyl-4-(pyridin-4-ylethynyl)aniline;N,N-DIETHYL-4-[2-(PYRIDIN-4-YL)ETHYNYL]ANILINE;N,N-diethyl-4-(2-pyridin-4-ylethynyl)aniline;DTXSID20462000;N,N-Diethyl-N-[4-(2-(pyridin-4-yl)ethynyl)phenyl]amine

Suppliers and Price of Benzenamine, N,N-diethyl-4-(4-pyridinylethynyl)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Total 1 raw suppliers

Chemical Property of Benzenamine, N,N-diethyl-4-(4-pyridinylethynyl)-

Chemical Property:

XLogP3:3.7
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:5
Exact Mass:250.146998583
Heavy Atom Count:19
Complexity:307

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CCN(CC)C1=CC=C(C=C1)C#CC2=CC=NC=C2

Technology Process of Benzenamine, N,N-diethyl-4-(4-pyridinylethynyl)-

There total 3 articles about Benzenamine, N,N-diethyl-4-(4-pyridinylethynyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 41876-70-4
4-ethynyl-N,N-diethylaniline

: 19524-06-2
4-bromopyridine hydrochloride

: 562813-17-6
N,N-diethyl-N-[4-(2-(pyridin-4-yl)ethynyl)phenyl]amine

: bis-(p-diethylaminophenyl)butadiyne

Guidance literature:: With piperidine; copper(l) iodide; hydrogen; bis-triphenylphosphine-palladium(II) chloride; In acetonitrile; for 8h; Heating;
DOI:10.1021/ol034320+

Reference yield:

: 57702-49-5
N,N-diethyl-4-iodo-aniline

: 562813-17-6
N,N-diethyl-N-[4-(2-(pyridin-4-yl)ethynyl)phenyl]amine

Guidance literature:: Multi-step reaction with 3 steps

1: 99.6 percent / H₂; CuI; triethylamine / dichlorobis(triphenylphosphine)palladium(II) / 2 h / 20 °C

2: 94 percent / K₂CO₃ / methanol / 2 h

3: 95 percent / H₂; CuI; piperidine / dichlorobis(triphenylphosphine)palladium(II) / acetonitrile / 8 h / Heating

With piperidine; copper(l) iodide; hydrogen; potassium carbonate; triethylamine; bis-triphenylphosphine-palladium(II) chloride; In methanol; acetonitrile; 1: Sonogashira coupling / 3: Sonogashira coupling;
DOI:10.1021/ol034320+

Reference yield:

: 562813-15-4
N,N-diethyl-4-[(trimethylsilyl)ethynyl]aniline

: 562813-17-6
N,N-diethyl-N-[4-(2-(pyridin-4-yl)ethynyl)phenyl]amine

Guidance literature:: Multi-step reaction with 2 steps

1: 94 percent / K₂CO₃ / methanol / 2 h

2: 95 percent / H₂; CuI; piperidine / dichlorobis(triphenylphosphine)palladium(II) / acetonitrile / 8 h / Heating

With piperidine; copper(l) iodide; hydrogen; potassium carbonate; bis-triphenylphosphine-palladium(II) chloride; In methanol; acetonitrile; 2: Sonogashira coupling;
DOI:10.1021/ol034320+