(3-(Hydroxymethyl)phenyl)(phenyl)methanone

Base Information

• Chemical Name: (3-(Hydroxymethyl)phenyl)(phenyl)methanone
• CAS No.: 56338-25-1
• Molecular Formula: C14H12O2
• Molecular Weight: 212.248
• DSSTox Substance ID: DTXSID30509778
• Nikkaji Number: J1.670.946H
• Wikidata: Q82367634
• Mol file: 56338-25-1.mol

Synonyms:3-(hydroxymethyl)benzophenone

Chemical Property of (3-(Hydroxymethyl)phenyl)(phenyl)methanone

Chemical Property:

• XLogP3: 2.4
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 212.083729621
• Heavy Atom Count: 16
• Complexity: 231

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)C(=O)C2=CC=CC(=C2)CO

Technology Process of (3-(Hydroxymethyl)phenyl)(phenyl)methanone

There total 13 articles about (3-(Hydroxymethyl)phenyl)(phenyl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

(3-(((tert-butyldimethylsilyl)oxy)methyl)phenyl)(phenyl)methanone → [3-(hydroxymethyl)phenyl](phenyl)methanone (56338-25-1)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; Inert atmosphere;

DOI:10.1002/anie.201604149

Reference yield: 82.0%

3-benzoylbenzoic acid (579-18-0) → [3-(hydroxymethyl)phenyl](phenyl)methanone (56338-25-1)

Guidance literature:

3-benzoylbenzoic acid; With trimethylphenylsilane; C₆₉H₅₅ClP₃Ru; In tetrahydrofuran; at 60 ℃; for 16h; Glovebox;

With hydrogenchloride; In tetrahydrofuran; water; at 20 ℃; for 1h; chemoselective reaction; Glovebox;

DOI:10.1002/adsc.201301088

Reference yield:

3-benzoylbenzyl bromide (22071-24-5) → [3-(hydroxymethyl)phenyl](phenyl)methanone (56338-25-1)

Guidance literature:

With calcium carbonate; In 1,4-dioxane; water; Heating;

DOI:10.1021/ol051381u

upstream raw materials:

3-benzoylbenzyl bromide

3-methyl benzophenone

3-benzoylbenzoic acid

ketoprofen

Downstream raw materials:

3-(hydroxy(phenyl)methyl)benzaldehyde

3-benzoylbenzaldehyde

3-(α-hydroxy-4'-methylbenzyl)benzophenone

3-(2',2'-dibromoethenyl)-2,2-dimethylcyclopropanecarboxylic acid