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Ketoprofen

Base Information Edit
  • Chemical Name:Ketoprofen
  • CAS No.:22071-15-4
  • Deprecated CAS:172964-50-0,22161-86-0,154907-35-4,154907-35-4,22161-86-0
  • Molecular Formula:C16H14O3
  • Molecular Weight:254.285
  • Hs Code.:29183000
  • European Community (EC) Number:244-759-8
  • NSC Number:758144
  • UNII:90Y4QC304K
  • DSSTox Substance ID:DTXSID6020771
  • Nikkaji Number:J389.199B,J389.200J,J3.468A
  • Wikipedia:Ketoprofen
  • Wikidata:Q409192
  • NCI Thesaurus Code:C47578
  • RXCUI:6142
  • Pharos Ligand ID:S3228AZ73B9C
  • Metabolomics Workbench ID:143005
  • ChEMBL ID:CHEMBL571
  • Mol file:22071-15-4.mol
Ketoprofen

Synonyms:3-Benzoyl-alpha-methylbenzeneacetic acid;Epatec;Oruvail;Orudis;Ketoprofen (JP14/USP);2-(3-Benzoylphenyl)propionic acid;3-Benzoylhydratropic acid;Profenid;Benzeneacetic acid,3-benzoyl-R-methyl-;LAcide (benzoyl-3-phenyl)-2-propionique;Alrheumate;m-Benzoylhydratropic acid;ISO-K;Orudis (TN);

Suppliers and Price of Ketoprofen
Supply Marketing:Edit
Business phase:
The product has achieved commercial mass production*data from LookChem market partment
Manufacturers and distributors:
  • Manufacture/Brand
  • Chemicals and raw materials
  • Packaging
  • price
  • Usbiological
  • Ketoprofen
  • 500ul
  • $ 393.00
  • TRC
  • racKetoprofen
  • 250mg
  • $ 50.00
  • TRC
  • racKetoprofen
  • 10g
  • $ 65.00
  • TCI Chemical
  • Ketoprofen >98.0%(HPLC)(T)
  • 250g
  • $ 986.00
  • TCI Chemical
  • Ketoprofen >98.0%(HPLC)(T)
  • 25g
  • $ 157.00
  • Sigma-Aldrich
  • Ketoprofen VETRANAL?, analytical standard
  • 100 mg
  • $ 65.20
  • Sigma-Aldrich
  • Ketoprofen VETRANAL , analytical standard
  • 100mg-r
  • $ 63.20
  • Sigma-Aldrich
  • Ketoprofen ≥98% (TLC)
  • 1g
  • $ 51.60
  • Sigma-Aldrich
  • Ketoprofen ≥98% (TLC)
  • 5g
  • $ 132.00
  • Sigma-Aldrich
  • Ketoprofen Pharmaceutical Secondary Standard; Certified Reference Material
  • 500mg
  • $ 87.20
Total 249 raw suppliers
Chemical Property of Ketoprofen Edit
Chemical Property:
  • Appearance/Colour:white crystalline solid 
  • Vapor Pressure:0mmHg at 25°C 
  • Melting Point:69-71 °C 
  • Refractive Index:1.592 
  • Boiling Point:431.3 °C at 760 mmHg 
  • PKA:pKa 5.94(MeOH/H2O) (Uncertain) 
  • Flash Point:147 °C 
  • PSA:54.37000 
  • Density:1.198 g/cm3 
  • LogP:3.10570 
  • Storage Temp.:0-6°C 
  • Solubility.:Slightly soluble in chloroform and methanol. 
  • Water Solubility.:209mg/L(room temperature) 
  • XLogP3:3.1
  • Hydrogen Bond Donor Count:1
  • Hydrogen Bond Acceptor Count:3
  • Rotatable Bond Count:4
  • Exact Mass:254.094294304
  • Heavy Atom Count:19
  • Complexity:331
Purity/Quality:

98.5%-101.0%, *data from raw suppliers

Ketoprofen *data from reagent suppliers

Safty Information:
  • Pictogram(s): Toxic
  • Hazard Codes:
  • Statements: 25-36/37/38-23/24/25 
  • Safety Statements: 26-45-36/37/39 
MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:
  • Drug Classes:Antiinflammatory Agents, Nonsteroidal
  • Canonical SMILES:CC(C1=CC(=CC=C1)C(=O)C2=CC=CC=C2)C(=O)O
  • Recent ClinicalTrials:Lymphedema Study for Arm or Leg Lymphedema
  • Recent EU Clinical Trials:Efficacy and safety of methoxyflurane vaporized (PENTHROX?) in the treatment of acute trauma pain in pre-hospital setting and in the emergency department in Italy: a multicentre, randomized, controlled, open-label study
  • Recent NIPH Clinical Trials:Cocktail analgesics during spinal surgery
  • Description Ketoprofen is a chemical that comes in the form of a white crystalline powder; odorless or nearly odorless. It is very soluble in methanol, soluble in ethanol, acetone or ether, and almost insoluble in water. The melting point is about 93-96 °C. For the arylalkanoic acid compounds. Has analgesic, anti-inflammatory and antipyretic effects. The anti-inflammatory effect is stronger than that of ibuprofen, with less side effects and low toxicity. Oral and easily absorbed from the gastrointestinal tract. After 1 administration, the peak plasma concentration can be reached in about 0.5 to 2 hours. t 1/2 is 1.6 to 1.9 hours. In the blood and plasma protein binding force is extremely strong. The excretion rate from urine is 30% to 90% within 24 hours. Mainly excreted in the form of glucuronic acid conjugates. For rheumatoid arthritis, rheumatoid arthritis, osteoarthritis, ankylosing spondylitis and gout, etc. Ketoprofen (3-benzoyl-α-methylphenylacetic acid) is a 2-arylpropionic acid potent non-steroidal anti-inflammatory drug. It was first synthesized by French chemist Rhone Poulenc in 1967. In 1973, it was introduced into France and the United States as an anti-inflammatory drug. It has good effects on rheumatism, rheumatoid arthritis, myelitis and gout, and its anti-inflammatory effect is stronger than that of ibuprofen. Ibuprofen. At the same dose, its anti-inflammatory and analgesic effect is 150 times that of aspirin, its antipyretic effect is 4 times that of indomethacin and 100 times that of aspirin. Because ketoprofen has high efficacy, short half-life, It has the advantages of simple metabolism and few and mild adverse reactions, and has been widely used in the treatment of various types of pain, inflammatory symptoms, colds and post-operative anti-inflammatory analgesia.
  • Uses Anti-inflammatory; analgesic Natural Vitamin B12. analog Ketoprofen, a propionic acid derivative, is a nonsteroidal anti-inflammatory agent (NSAIA) with analgesic and antipyretic properties.
  • Indications Ketoprofen (Orudis) is indicated for use in rheumatoid and osteoarthritis, for mild to moderate pain, and in dysmenorrhea. The most frequently reported side effects are GI (dyspepsia, nausea, abdominal pain, diarrhea, constipation, and flatulence) and CNS related (headache, excitation). Edema and increased blood urea nitrogen have also been noted in more than 3% of patients. Ketoprofen can cause fluid retention and increases in plasma creatinine, particularly in the elderly and in patients taking diuretics.
  • Therapeutic Function Antiinflammatory
  • Clinical Use Ketoprofen, unlike many NSAIDs, inhibits the synthesis of leukotrienes and leukocyte migration into inflamed joints in addition to inhibiting the biosynthesis of prostaglandins. It stabilizes the lysosomal membrane during inflammation, resulting in decreased tissue destruction. Antibradykinin activity also has been observed. Bradykinin is released during inflammation and can activate peripheral pain receptors. In addition to anti-inflammatory activity, ketoprofen also possesses antipyretic and analgetic properties. Although it is less potent than indomethacin as an anti-inflammatory agent and an analgetic, its ability to produce gastric lesions is about the same.
  • Drug interactions Concomitant use of alcohol or other NSAIDs after taking ketoprofen can increase gastrointestinal side effects and may cause ulcers. When ketoprofen is used together with aspirin or other salicylic acid drugs, the efficacy cannot be increased, but the incidence of gastrointestinal side effects and bleeding tendency increases. Concomitant use of ketoprofen with anticoagulants increases the risk of bleeding. Ketoprofen can enhance the effect of antidiabetic drugs and reduce the antihypertensive effect of antihypertensive drugs; ketoprofen and corticosteroids can be used together, which can significantly reduce the symptoms of inflammation. Ketoprofen should not be used with methotrexate to prevent poisoning. When ketoprofen is used with probenecid, verapamil, and nifedipine, the dose should be reduced; when ketoprofen is used with digoxin, the dose of digoxin should be adjusted.
Technology Process of Ketoprofen

There total 139 articles about Ketoprofen which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:
Guidance literature:
With potassium trimethylsilonate; In tetrahydrofuran; at 20 ℃; for 12h;
DOI:10.1021/jo010425j
Guidance literature:
With palladium diacetate; catacxium A; In 1,4-dioxane; at 100 ℃; for 20h;
DOI:10.1021/jo5010185
Guidance literature:
With potassium hydroxide; In tetrahydrofuran; at 25 ℃; for 24h;
DOI:10.1016/S0040-4020(01)85294-7
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