Phosphonic acid, (1-aminocyclohexyl)-, diethyl ester

Base Information

Chemical Name:Phosphonic acid, (1-aminocyclohexyl)-, diethyl ester
CAS No.:56372-35-1
Molecular Formula:C10H22NO3P
Molecular Weight:235.263
Hs Code.:
DSSTox Substance ID:DTXSID90443129
Wikidata:Q82260837

Synonyms:56372-35-1;Phosphonic acid, (1-aminocyclohexyl)-, diethyl ester;DTXSID90443129

Suppliers and Price of Phosphonic acid, (1-aminocyclohexyl)-, diethyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Phosphonic acid, (1-aminocyclohexyl)-, diethyl ester

Chemical Property:

PSA：71.36000
LogP:3.57190
XLogP3:1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:5
Exact Mass:235.13373056
Heavy Atom Count:15
Complexity:229

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCOP(=O)(C1(CCCCC1)N)OCC

Technology Process of Phosphonic acid, (1-aminocyclohexyl)-, diethyl ester

There total 6 articles about Phosphonic acid, (1-aminocyclohexyl)-, diethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 108-94-1,11119-77-0,9003-41-2,9075-99-4
cyclohexanone

: 762-04-9
phosphonic acid diethyl ester

: 56372-35-1
diethyl 1-aminocyclohexylphosphonate

Guidance literature:: With aluminium(III) triflate; 1,1,1,3,3,3-hexamethyl-disilazane; at 80 ℃; for 2h; Solvent-free conditions;
DOI:10.1002/hc.20517

Reference yield: 77.0%

: 186187-32-6
diethyl α-azido cyclohexylphosphonate

: 56372-35-1
diethyl 1-aminocyclohexylphosphonate

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethanol; at 20 ℃; for 3h; under 750.06 Torr;
DOI:10.1080/00397919608004650

Reference yield:

: 7413-09-4
Cyclohexyl-phosphonic acid diethyl ester

: 56372-35-1
diethyl 1-aminocyclohexylphosphonate

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) BuLi / 1.) THF, -78 deg C, 30 min, 2.) THF, -78 deg C, 1 h

2: tetrahydrofuran; acetic acid / 3 h / Ambient temperature

3: 77 percent / H₂ / Pd/C / ethanol / 3 h / 20 °C / 750.06 Torr

With n-butyllithium; hydrogen; palladium on activated charcoal; In tetrahydrofuran; ethanol; acetic acid;
DOI:10.1080/00397919608004650