diethyl α-azido cyclohexylphosphonate

Base Information

• Chemical Name: diethyl α-azido cyclohexylphosphonate
• CAS No.: 186187-32-6
• Molecular Formula: C₁₀H₂₀N₃O₃P
• Molecular Weight: 261.261
• Mol file: 186187-32-6.mol

Synonyms:diethyl α-azido cyclohexylphosphonate

Chemical Property of diethyl α-azido cyclohexylphosphonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of diethyl α-azido cyclohexylphosphonate

There total 2 articles about diethyl α-azido cyclohexylphosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Cyclohexyl-phosphonic acid diethyl ester (7413-09-4) → diethyl α-azido cyclohexylphosphonate (186187-32-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) BuLi / 1.) THF, -78 deg C, 30 min, 2.) THF, -78 deg C, 1 h

2: tetrahydrofuran; acetic acid / 3 h / Ambient temperature

With n-butyllithium; In tetrahydrofuran; acetic acid;

DOI:10.1080/00397919608004650

Reference yield:

C25H44N3O5PS → 1-(diethylphosphono)cyclohexene (31651-16-8) + diethyl α-azido cyclohexylphosphonate (186187-32-6)

Guidance literature:

In tetrahydrofuran; acetic acid; for 3h; Yield given. Yields of byproduct given. Title compound not separated from byproducts; Ambient temperature;

DOI:10.1080/00397919608004650

Reference yield: 77.0%

diethyl α-azido cyclohexylphosphonate (186187-32-6) → diethyl 1-aminocyclohexylphosphonate (56372-35-1)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol; at 20 ℃; for 3h; under 750.06 Torr;

DOI:10.1080/00397919608004650

upstream raw materials:

Cyclohexyl-phosphonic acid diethyl ester

Downstream raw materials:

diethyl 1-aminocyclohexylphosphonate

α-amino cyclohexylphosphonic acid