6-Fluoro-2-methylquinolin-4-ol

Base Information

• Chemical Name: 6-Fluoro-2-methylquinolin-4-ol
• CAS No.: 15912-68-2
• Molecular Formula: C10H8FNO
• Molecular Weight: 177.178
• Hs Code.: 2933499090
• European Community (EC) Number: 240-054-4
• DSSTox Substance ID: DTXSID60166590
• Nikkaji Number: J219.900I
• Wikidata: Q72474995
• Mol file: 15912-68-2.mol

Synonyms:6-fluoro-2-methylquinolin-4(1H)-one;HEI 712;HEI-712;HEI712

Chemical Property of 6-Fluoro-2-methylquinolin-4-ol

Chemical Property:

• Vapor Pressure: 0.321mmHg at 25°C
• Melting Point: 273-277 °C(lit.)
• Refractive Index: 1.391
• Boiling Point: 275.7 °C at 760 mmHg
• PKA: 4.22±0.40(Predicted)
• Flash Point: 120.5 °C
• PSA: 33.12000
• Density: 1.228 g/cm³
• LogP: 2.38790
• Storage Temp.: Room temperature.
• XLogP3: 2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 0
• Exact Mass: 177.058992041
• Heavy Atom Count: 13
• Complexity: 262

Purity/Quality:

97% ^*data from raw suppliers

6-Fluoro-2-methyl-4-quinolinol >98.0%(GC)(T) ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC(=O)C2=C(N1)C=CC(=C2)F

Technology Process of 6-Fluoro-2-methylquinolin-4-ol

There total 6 articles about 6-Fluoro-2-methylquinolin-4-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl acetoacetate (141-97-9) + 4-fluoroaniline (371-40-4) → 6-fluoro-2-methylquinolin-4-ol (15912-68-2)

Guidance literature:

With polyphosphoric acid; at 80 - 120 ℃; for 16.75h;

DOI:10.1016/j.ejmech.2013.08.028

Reference yield:

4-fluoroaniline (371-40-4) → 6-fluoro-2-methylquinolin-4-ol (15912-68-2)

Guidance literature:

Multi-step reaction with 2 steps

1: ammonium cerium (IV) nitrate / 40 °C

2: diphenylether / 0.5 h / 250 °C

With ammonium cerium (IV) nitrate; In diphenylether;

DOI:10.1248/cpb.60.659

Reference yield:

C12H14FNO2 (1392200-84-8) → 6-fluoro-2-methylquinolin-4-ol (15912-68-2)

Guidance literature:

With diphenylether; at 250 ℃; for 0.5h;

DOI:10.3390/molecules17055870

upstream raw materials:

4-fluoroaniline

C₁₂H₁₄FNO₂

ethyl 3-(N-4-fluorophenyl)aminobut-2-enoate

ethyl acetoacetate

Downstream raw materials:

4-chloro-6-fluoro-2-methylquinoline

(E)-N¹-(6-fluoro-2-(4-methoxystyryl)quinolin-4-yl)-N²,N²-dimethylethane-1,2-diamine

(E)-N¹-(6-fluoro-2-(4-fluorostyryl)quinolin-4-yl)-N²,N²-dimethylethane-1,2-diamine

(E)-N₁-(6-fluoro-2-(4-fluorostyryl)quinolin-4-yl)-N₃,N₃-dimethylpropane-1,3-diamine

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