3-fluoro-4-(MethylsulfonylaMino)benzylaMine

Base Information

• Chemical Name: 3-fluoro-4-(MethylsulfonylaMino)benzylaMine
• CAS No.: 565448-36-4
• Molecular Formula: C8H11FN2O2S
• Molecular Weight: 218.252
• Mol file: 565448-36-4.mol

Synonyms:N-(4-aminomethyl-2-fluoro-phenyl)methanesulfonamide;Methanesulfonamide,N-[4-(aminomethyl)-2-fluorophenyl];3-fluoro-4-(methylsulfonylamino)benzylamine;N-[3-fluoro-4-(methylsulfonylamino)benzyl]hydroxylamine;

Chemical Property of 3-fluoro-4-(MethylsulfonylaMino)benzylaMine

Chemical Property:

• PSA: 80.57000
• LogP: 2.51000

Purity/Quality:

97% ^*data from raw suppliers

N-(4-AMINOMETHYL-2-FLUORO-PHENYL)METHANESULFONAMIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-fluoro-4-(MethylsulfonylaMino)benzylaMine

There total 10 articles about 3-fluoro-4-(MethylsulfonylaMino)benzylaMine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

mono-tert-butyl malonate (40052-13-9) + N-(2-fluoro-4-cyanophenyl)methanesulfonamide (401909-16-8) → N-(4-(aminomethyl)-2-fluorophenyl)methanesulfonamide (565448-36-4)

Guidance literature:

mono-tert-butyl malonate; N-(2-fluoro-4-cyanophenyl)methanesulfonamide; With dimethyl sulfide borane; In tetrahydrofuran; for 3h; Reflux;

With hydrogenchloride; In tetrahydrofuran; water; for 15h; Reflux;

DOI:10.1016/j.bmcl.2013.10.064

Reference yield: 92.0%

N-(2-fluoro-4-cyanophenyl)methanesulfonamide (401909-16-8) → N-(4-(aminomethyl)-2-fluorophenyl)methanesulfonamide (565448-36-4)

Guidance literature:

N-(2-fluoro-4-cyanophenyl)methanesulfonamide; With dimethylsulfide borane complex; In tetrahydrofuran; for 3h; Reflux;

With hydrogenchloride; In tetrahydrofuran; water; for 15h; Reflux;

DOI:10.1016/j.bmcl.2013.10.064

Reference yield:

tert-butyl N-[(tert-butoxycarbonyl)oxy]-N-[3-fluoro-4-(methylsulfonylamino)benzyl]carbamate → N-(4-(aminomethyl)-2-fluorophenyl)methanesulfonamide (565448-36-4)

Guidance literature:

With trifluoroacetic acid; at 0 - 20 ℃; for 0.833333h;

upstream raw materials:

N-(2-fluoro-4-cyanophenyl)methanesulfonamide

2-fluro-4-iodoaniline

2-fluoro-4-iodo-1-methanesulfonylaminobenzene

mono-tert-butyl malonate

Downstream raw materials:

1-(4-t-butylbenzyl)-3-(3-fluoro-4-methanesulfonylaminobenzyl)thiourea

C₂₇H₃₈FN₃O₄S₂

C₂₆H₃₆FN₃O₄S₂

C₂₈H₄₀FN₃O₄S₂